Clinical characteristic of psychiatric symptoms in Acute Intermittent Porphyria (AIP): A report of a pair of identical twins

Tay, Jing Ling; Lal, Manu

doi:10.1016/j.ajp.2017.07.023

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…Some patients with AIP may also experience a variety of psychiatric symptoms, such as depression, anxiety, and insomnia (56-61). Severe cases can even manifest as schizophrenia and hallucinations (25,(62)(63)(64). Psychiatric symptoms may occur during an acute episode or as a chronic complication.…”

Section: Psychiatric Symptomsmentioning

confidence: 99%

Acute intermittent porphyria: focus on possible mechanisms of acute and chronic manifestations

Teng

Zhang

et al. 2020

IRDR

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acute intermittent porphyria, mechanisms, aminolevulinic acid (ALA), attack Porphyrias are a group of inherited metabolic diseases that include eight types, each of which is caused by a mutation that affects an enzyme of the heme biosynthetic pathway. When an enzyme defect has physiological significance, it leads to overproduction of pathway precursors prior to the defective step. The partial absence of the third enzyme in the heme biosynthetic pathway, porphobilinogen deaminase (PBGD) also known as hydroxymethylbilane synthase (HMBS), results in acute intermittent porphyria (AIP), which affects mainly women. Subjects who had AIP symptoms were deemed to have manifest AIP (MAIP). Clinical manifestations are usually diverse and non-specific. Acute AIP episodes may present with abdominal pain, nausea, and vomiting, and repeated episodes may result in a series of chronic injuries. Therefore, studying the mechanisms of acute and chronic manifestations of AIP is of great significance. This review aims to summarize the possible mechanisms of acute and chronic manifestations in patients with AIP.

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Section: Psychiatric Symptomsmentioning

confidence: 99%

Acute intermittent porphyria: focus on possible mechanisms of acute and chronic manifestations

Teng

Zhang

et al. 2020

IRDR

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“…3 Women are more commonly affected than men. 4 The prevalence of acute porphyria among psychiatric patients is 0.21%-0.48% which was considered to be higher than the typical population as mentioned in the article by Tay et al 5 Acute intermittent porphyria has a prevalence of about 1 in 20,000. 6 Women are affected more than men in the ratio 1.5-2:1 and usually present with symptoms after menarche.…”

Section: Discussionmentioning

confidence: 95%

Acute Intermittent Porphyria- Perplexed by the Purple

Dutta¹,

Rajbhandari

Thapa

et al. 2018

Nepal Med Jor

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Porphyrias are rare, genetically inherited group of disorders. The most common disorder among acute porphyrias are the acute intermittent porphyria, which occurs due a defect of the enzyme porphobilinogendeaminase, presenting commonly with a triad of symptoms: visceral abdominal pain, diagnostic confusion and delay, leading to multiple investigations, unnecessary treatment interventions, high cost of management, with frequent visits to emergency room and a prolonged ward stay. A more for years as "Functional", Malingerers, Mentally ill. In underdeveloped countries, owing to limited investigative procedures, costly laboratory investigations, poor socio-economic status, much reliance on clinical judgment is required.

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Acute Hepatic Porphyrias: “Purple Flags”—Clinical Features That Should Prompt Specific Diagnostic Testing

Anderson

Desnick

Stewart

et al. 2022

The American Journal of the Medical Sciences

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Clinical characteristic of psychiatric symptoms in Acute Intermittent Porphyria (AIP): A report of a pair of identical twins

Cited by 3 publications

References 3 publications

Acute intermittent porphyria: focus on possible mechanisms of acute and chronic manifestations

Acute intermittent porphyria: focus on possible mechanisms of acute and chronic manifestations

Acute Intermittent Porphyria- Perplexed by the Purple

Acute Hepatic Porphyrias: “Purple Flags”—Clinical Features That Should Prompt Specific Diagnostic Testing

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