Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia

Abstract

In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children’s Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age < 5 years, G4P[8] (45.5%), G2P[4] (18.2%), G9P[8], G3P[8], and G1P[8] (9.1%) in children of age > 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.

A Cross-sectional Study on the Role of Rotavirus and Microbial Co-infection in Children with Acute Diarrhea in Vietnam

“…Our analysis demonstrated that children with Rotavirus-positive cases exhibited a higher prevalence of watery stools, vomiting, and a higher frequency of loose stools per day compared to Rotavirus-negative cases (P < 0.05). These findings align with well-documented evidence in medical literature and prior studies, as Rotavirus-induced gastrointestinal disease typically presents with watery stools, mild fever, vomiting, and mild inflammation causing intestinal damage (12,19,20). It is worth noting that most children affected by acute Rotavirus diarrhea experienced fever (86.3%); however, this difference was not statistically significant between children with and without Rotavirus infection.…”

Rotavirus Strain Surveillance in Estonia After Introduction of Rotavirus Universal Mass Vaccination

“…22 Our study also adds to existing knowledge about possible differences in the clinical profile by genotype. Laizane et al 25 has shown that increased vomiting episodes are associated with G1P [8] compared with other genotypes, which is in accordance with the findings in our study. Also, they showed a higher rate of fever and vomiting for genotype G8P [8], which in our study was associated with longer hospital stays.…”

Multicenter Study of Rotavirus Infection, Diversity of Circulating Genotypes and Clinical Outcomes in Children ≤5 Years Old in Iran

“…In Qatar, fever was more frequent in children infected with G3P [8] genotype, 35 while a study in Latvia reported lower fever occurrence with G3P [8] genotype compared with other genotypes. 36 Among children with single-type infection, all G1P [6]-infected patients had nausea with milder diarrhea. In contrast, children with mixed-type infections experienced more severe diarrhea but lower nausea, which is similar to that reported in Indonesia.…”