Clinical characterisation and long-term prognosis of women with Brugada syndrome

Sieira, Juan; Conte, Giulio; Ciconte, Giuseppe; Asmundis, Carlo de; Chierchia, Gian‐Battista; Baltogiannis, Giannis; Giovanni, Giacomo Di; Saitoh, Yukio; Irfan, Ghazala; Casado-Arroyo, Rubén; Juliá, Justo; Meir, Mark La; Wellens, Francis; Wauters, Kristel; Pappaert, Gudrun; Brugada, Pedro

doi:10.1136/heartjnl-2015-308556

Cited by 58 publications

(44 citation statements)

References 32 publications

(44 reference statements)

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“…In the Japanese guideline in 2012, the Class IIa indication of an ICD for the primary prevention is that patients who have Brugada‐type (coved‐type) ECG (spontaneous or drug‐induced, documented in the superior positions) and meet at least two of the following three conditions: (i) history of syncope (likely caused VT/VF), (ii) family history of sudden death (SD), and (iii) VF induced during EPS. As mentioned before, SND has been reported to be a risk factor for lethal arrhythmic events . Presentation of SND might be an additional factor for considering an ICD implantation.…”

Section: Management Of Brugada Syndrome Patients With Sinus Node Dysfmentioning

confidence: 71%

“…However, that high prevalence was derived from the EPS‐induced SND cases, not the clinically documented SND or SSS cases. In adults, although the prevalence of clinically documented SND in patients with BrS was relatively high (7.9% and 8.8%) in the small‐population studies, it was not so high (1.1%‐1.7%) in the more recent large‐population studies . In children, the prevalence of SND seems to be higher (6.7%‐9.0%) compared to the adult patients .…”

Section: Prevalence Of the Association Between Brugada Syndrome And Smentioning

confidence: 97%

“…Although the multivariate analysis was not significant, univariate analysis identified that previous SND was a risk factor for arrhythmic events (hazard ratio, 8.0; 95% confidence interval, 1.0‐63.9; P = .05) . Sieira et al also studied a consecutive cohort of 228 women with spontaneous or drug‐induced type 1 ECG (asymptomatic: 75%). They reported an event rate of 0.7% per year during a mean follow‐up of 73.2 ± 56.2 months.…”

Section: Prognostic Value Of Sinus Node Dysfunction In Patients With mentioning

confidence: 99%

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Brugada syndrome and sinus node dysfunction

Hayashi

Sumiyoshi

Nakazato

et al. 2018

Journal of Arrhythmia

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Brugada syndrome (BrS) is a well‐known catastrophic disease first reported in 1992 by the Brugada brothers. Ventricular fibrillation (VF) is an essential arrhythmia in BrS. An association between BrS and atrial tachyarrhythmias is not uncommon. However, sinus node dysfunction (SND) associated with BrS has not been well discussed. In this review, we focus on the association between BrS and SND. Based on previous reports describing clinical, epidemiological, and genetic evidence, SND is not a rare concomitant disorder in BrS. BrS may be a multiple conduction or arrhythmogenic disorder including not only the His‐Purkinje system and right ventricle, but also the sinus node and atrium, derived from ion channel mutations.

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Section: Management Of Brugada Syndrome Patients With Sinus Node Dysfmentioning

confidence: 71%

Section: Prevalence Of the Association Between Brugada Syndrome And Smentioning

confidence: 97%

Section: Prognostic Value Of Sinus Node Dysfunction In Patients With mentioning

confidence: 99%

See 1 more Smart Citation

Brugada syndrome and sinus node dysfunction

Hayashi

Sumiyoshi

Nakazato

et al. 2018

Journal of Arrhythmia

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“…have shown that women represent 42% of BrS population in their database. Of note, women tended to be more often asymptomatic and displayed less commonly the diagnostic type 1 ECG pattern . The clinical presentation in women is more benign and the prognosis is also more favorable with an annual event rate of 0.25% …”

Section: Current Risk Stratification Tools In Brsmentioning

confidence: 99%

Prognosis, risk stratification, and management of asymptomatic individuals with Brugada syndrome: A systematic review

Letsas

Asvestas

Baranchuk

et al. 2017

Pacing Clinical Electrophis

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Brugada syndrome (BrS) is a primary electrical disease associated with increased risk of sudden cardiac death due to polymorphic ventricular arrhythmias. The prognosis, risk stratification, and management of asymptomatic individuals remain the most controversial issues in BrS. Furthermore, the decision to manage asymptomatic patients with an implantable cardioverter‐defibrillator should be made after weighing the potential individual risk of future arrhythmic events against the risk of complications associated with the implant and follow‐up of patients living with such devices, and the accompanying impairment of the quality of life. Several clinical, electrocardiographic, and electrophysiological markers have been proposed for risk stratification of subjects with BrS phenotype, but the majority have not yet been tested in a prospective manner in asymptomatic individuals. Recent data suggest that current risk factors are insufficient and cannot accurately predict sudden cardiac death events in this setting. This systematic review aims to discuss contemporary data regarding prognosis, risk stratification, and management of asymptomatic individuals with diagnosis of Brugada electrocardiogram pattern and to delineate the therapeutic approach in such cases.

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“…19 Physical activity might have a pro-arrhythmic effect, associated with either hyperthermia or sympathetic withdrawal and/or increased vagal tonus in athletes after exertion. However, that association is still uncertain and the North-American guidelines do not recommend sports restrictions for those patients.…”

Section: Introductionmentioning

confidence: 99%