Clinical CFD Applications 2

Validation and Sensitivity analysis for a nasal spray deposition computational model

“…Literature on the validation of particle deposition in the human nasal cavity is scarce [18,48]. In contrast, extensive literature exists on particle deposition in the throat [49,10,11]. The experimental setup allows measuring the deposition on each independent region thanks to the separate nasal cast pieces, see of the time the authors prefer to segment the airways into two regions [18,50] to obtain an anterior and posterior part.…”

“…Numerical simulations (in-silico) using computational fluid dynamics (CFD) guided with experimental measurements (in-vitro) are an appealing approach that can reduce the cost and time related to device testing [10,11]. CFD is an efficient tool to evaluate the performance of a nasal spray products on realistic nasal airway models under multiple conditions [12,13,14].…”