Clinical Cerebral Preconditioning and Postconditioning

Dezfulian, Cameron

doi:10.1007/978-1-4419-9695-4_26

Cited by 1 publication

(2 citation statements)

References 50 publications

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“…While the sublethal ischemia may last for an hour or more in focal models, it is generally in the order of a few minutes for global IPC. The degree of protection against ischemia has a distinctive time frame: heightened protection for a few minutes with subsequent decline and remote protection that sets in after a day and quite possibly lasts a week [17,42].…”

Section: Experimental Modelsmentioning

confidence: 99%

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Cerebral Ischemic Preconditioning: the Road So Far…

Sangwan

Sharma

et al. 2015

Mol Neurobiol

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Cerebral preconditioning constitutes the brain's adaptation to lethal ischemia when first exposed to mild doses of a subtoxic stressor. The phenomenon of preconditioning has been largely studied in the heart, and data from in vivo and in vitro models from past 2-3 decades have provided sufficient evidence that similar machinery exists in the brain as well. Since preconditioning results in a transient protective phenotype labeled as ischemic tolerance, it can open many doors in the medical warfare against stroke, a debilitating cerebrovascular disorder that kills or cripples thousands of people worldwide every year. Preconditioning can be induced by a variety of stimuli from hypoxia to pharmacological anesthetics, and each, in turn, induces tolerance by activating a multitude of proteins, enzymes, receptors, transcription factors, and other biomolecules eventually leading to genomic reprogramming. The intracellular signaling pathways and molecular cascades behind preconditioning are extensively being investigated, and several first-rate papers have come out in the last few years centered on the topic of cerebral ischemic tolerance. However, translating the experimental knowledge into the clinical scaffold still evades practicality and faces several challenges. Of the various preconditioning strategies, remote ischemic preconditioning and pharmacological preconditioning appears to be more clinically relevant for the management of ischemic stroke. In this review, we discuss current developments in the field of cerebral preconditioning and then examine the potential of various preconditioning agents to confer neuroprotection in the brain.

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Section: Experimental Modelsmentioning

confidence: 99%

“…Ischemic postconditioning (IPost) is the method of inducing tolerance after occurrence of the event. It works by the periodic applications of brief ischemic stress following reperfusion and helps in cerebrovascular regeneration and protection [17].…”

Section: Understanding Cerebral Preconditioningmentioning

confidence: 99%

Cerebral Ischemic Preconditioning: the Road So Far…

Sangwan

Sharma

et al. 2015

Mol Neurobiol

View full text Add to dashboard Cite

show abstract

Clinical Cerebral Preconditioning and Postconditioning

Cited by 1 publication

References 50 publications

Cerebral Ischemic Preconditioning: the Road So Far…

Cerebral Ischemic Preconditioning: the Road So Far…

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