Clinical case reports of injectable tissue-engineered bone for alveolar augmentation with simultaneous implant placement

Yamada, Yoichi; Ozawa, Ryotaro; Okazaki, Yoshiaki

doi:10.1016/j.prosdent.2005.05.019

Cited by 53 publications

(60 citation statements)

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“…The outcome of this clinical trial was not superior to that of conventional reconstructive approaches [85]. Periosteal cell-seeded polymer fleeces or mesenchymal stem cells and platelet-rich plasma, immobilized in beta-tricalcium phosphate scaffolds induced bone formation in sinus lift operations [86][87][88]. Despite anecdotal reports of successful implantation of engineered bone tissues, the small number of patients makes it difficult to eventually assess the efficacy of these constructs and comparison with conventional methods has not been performed yet.…”

Section: Osteogenic Cellsmentioning

confidence: 81%

Tissue engineering of bone: the reconstructive surgeon's point of view

Kneser¹,

Schaefer

Polykandriotis³

et al. 2006

J Cellular Molecular Medi

462

350

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Bone defects represent a medical and socioeconomic challenge. Different types of biomaterials are applied for reconstructive indications and receive rising interest. However, autologous bone grafts are still considered as the gold standard for reconstruction of extended bone defects. The generation of bioartificial bone tissues may help to overcome the problems related to donor site morbidity and size limitations. Tissue engineering is, according to its historic definition, an "interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function". It is based on the understanding of tissue formation and regeneration and aims to rather grow new functional tissues than to build new spare parts. While reconstruction of small to moderate sized bone defects using engineered bone tissues is technically feasible, and some of the currently developed concepts may represent alternatives to autologous bone grafts for certain clinical conditions, the reconstruction of largevolume defects remains challenging. Therefore vascularization concepts gain on interest and the combination of tissue engineering approaches with flap prefabrication techniques may eventually allow application of bone-tissue substitutes grown in vivo with the advantage of minimal donor site morbidity as compared to conventional vascularized bone grafts. The scope of this review is the introduction of basic principles and different components of engineered bioartificial bone tissues with a strong focus on clinical applications in reconstructive surgery. Concepts for the induction of axial vascularization in engineered bone tissues as well as potential clinical applications are discussed in detail.

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Section: Osteogenic Cellsmentioning

confidence: 81%

Tissue engineering of bone: the reconstructive surgeon's point of view

Kneser¹,

Schaefer

Polykandriotis³

et al. 2006

J Cellular Molecular Medi

462

350

View full text Add to dashboard Cite

show abstract

“…However, their capacity to improve the osteogenicity of MSCs in vivo has not been well characterized. Recent studies have suggested positive, synergistic effects of MSCs and PRP mixtures in enhancing bone formation in the oral and maxillofacial regions (22,23).…”

Section: Introductionmentioning

confidence: 99%

Influence of Autologus Adipose Derived Stem Cells and PRP on Regeneration of Dehiscence-Type Defects in Alveolar Bone: A Comparative Histochemical and Histomorphometric Study in Dogs

Aly

Menoufy²,

Hassan³

et al. 2011

Int J Stem Cells

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Background and Objectives: Autogenous bone grafts is considered to be the best choice for reconstructive surgery. Adipose Derived Stromal Cells (ASCs) represents a promising tool for new clinical concepts in supporting cellular therapy. The goal of our study was to investigate bone regeneration following application of autologous ASCs with or without Platelet-Rich Plasma (PRP) at dehiscence-type defects in alveolar bone in dogs. Methods and Results: Standardized buccal dehiscence defects (4×3×3 mm) were surgically created in eighteen dogs, the defects were grafted with either ASCs -PRP, ASCs alone, or without grafting material. Three months later; a bone core was harvested from grafted and non grafted sites for histological, histochemical and histomorphometric assessment. There was no evidence of inflammation or adverse tissue reaction with either treatment. Defects grafted with ASCs-PRP showed a significantly higher result (p≤0.05), with a mean area % of spongy bone and compact bone of (64.96±5.37 and 837.62±24.95), compared to ASCs alone (47.65±1.43 and 661.92±12.65) and without grafting (33.55±1.74 and 290.85±7.27) respectively. The area % of lamellated bone increased significantly reaching its highest level in group A followed by group B. Also a significant increase in area % of neutral mucopolysaccharides and calcified reactivity of Masson's Trichrome stain in groups A and B compared to group C was obtained. Conclusions: Our results suggest that, the addition of PRP to ASCs enhances bone formation after 3 months and may be clinically effective in accelerating postsurgical healing in both periodontal and maxillofacial surgical applications.

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“…After that, same authors applied this injectable tissue-engineered bone to onlay plasty in the posterior maxilla or mandible in three human patient with simultaneous implant placement and reported stable and predictable results in terms of implant success [55]. In 2005, Ueda et al [56] have used MSCs in a clinical study undertaken to evaluate the use of tissue-engineered bone, MSCs, platelet-rich plasma, and beta-tricalcium phosphate as grafting materials for maxillary sinus floor augmentation and proclaimed that tissue-engineered bone provided stable and predictable results in terms of implant success.…”

Section: Mesenchymal Stem Cells In the Reconstruction Of The Osseous mentioning

confidence: 99%

Mesenchymal Stem Cells for Optimizing Bone Volume at the Dental Implant Recipient Site

Ayna¹,

Gülses²,

Wiltfang³

et al. 2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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Inadequate bone volume at the implant recipient site presents a clinical challenge for many dental practitioners. To overcome these problems, several approaches have been developed and are currently used, including bone grafting strategies and distraction osteogenesis. Mesenchymal stem cells (MSCs) have gained their popularity within the last two decades, with regard to promising clinical results in improving the bone architecture at the implant recipient site. The aim of this chapter was to briefly outline the accessibility properties, differentiation capacities, isolation, and characterization of MSCs with regard to optimizing bone volume in dental implantology. Additionally, potential benefits and pitfalls are discussed in comparison with the conventional bone augmentation techniques.

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Clinical case reports of injectable tissue-engineered bone for alveolar augmentation with simultaneous implant placement

Cited by 53 publications

References 0 publications

Tissue engineering of bone: the reconstructive surgeon's point of view

Tissue engineering of bone: the reconstructive surgeon's point of view

Influence of Autologus Adipose Derived Stem Cells and PRP on Regeneration of Dehiscence-Type Defects in Alveolar Bone: A Comparative Histochemical and Histomorphometric Study in Dogs

Mesenchymal Stem Cells for Optimizing Bone Volume at the Dental Implant Recipient Site

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