Clinical Case of Palmoplantar Keratoderma Type Unna-Thost

Palmoplantar keratoderma is a heterogeneous group of diseases, both hereditary and acquired, affecting, as a rule, the skin of the palms and soles in the form of focal or diffuse hyperkeratotic layers. Hereditary forms are characterized by a defect in the genes encoding certain structural components of keratinocytes, which leads to the corresponding clinical manifestations. The actual method of genomic sequencing has made it possible to identify the localization of defects in certain genes for specific types of hereditary palmoplantar keratoderma, however, despite the big step in diagnosis, therapy still remains complex and can only reduce the manifestations of the disease and improve the quality of life, and not cure it completely. The authors demonstrate a clinical case of UnnaToast keratoderma in a young patient with a long history of treatment of the disease, who showed a pronounced positive dynamics from the skin process against the background of the use of local agents, as well as the use of such a physiotherapeutic method as local PUVA therapy. In addition, the article provides a clinical case of hereditary keratoderma BuschkeFischerBrauer as an example of an accidentally diagnosed disease at a dermatologists appointment.

show abstract

Hereditary keratoderma. Clinical case: Unna–Toast keratoderma and Buschke–Fischer–Brauer keratoderma

Grabovskaya

Teplyuk

Kolesova

et al. 2022

Russian Journal of Skin and Venereal Diseases

View full text Add to dashboard Cite

show abstract

Hereditary keratoderma of Unna-Tost in a patient with atopic dermatitis

Teplyuk,

Tavitova,

Pishulina

et al. 2023

Russian Journal of Skin and Venereal Diseases

View full text Add to dashboard Cite

Unna-Toast's keratoderma is a disease belonging to the group of genodermatoses with an autosomal dominant type of inheritance and characterized by hyperkeratosis on the palms and soles. This nosology can manifest itself at any age as an independent process, but more often it debuts at 12 years of age, in some cases combined with various congenital malformations of ectodermal origin. The prevalence of this disease ranks second among hereditary dyskeratoses, however, it is rare in the practice of a dermatologist and there are no static data on the disease. The article presents a clinical observation of Unna-Toast's keratoderma that first appeared against the background of atopic dermatitis. The clinical picture is represented by smooth yellow horny layers located on the palms and soles, with a sharply defined border and an erythematous corolla along the periphery. Other areas of the skin are represented by lichenification foci with small-lamellar peeling, excoriations and serous-hemorrhagic crusts on the surface. This clinical case confirms the possibility of manifestation of hereditary hyperkeratosis against the background of aggressive atopic dermatitis. Unna-Tost's keratoderma is of high interest in the practice of a dermatologist and requires a detailed description of the available clinical cases, due to the rare occurrence of this nosology in the population.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Clinical Case of Palmoplantar Keratoderma Type Unna-Thost

Cited by 2 publications

References 14 publications

Hereditary keratoderma. Clinical case: Unna–Toast keratoderma and Buschke–Fischer–Brauer keratoderma

Hereditary keratoderma. Clinical case: Unna–Toast keratoderma and Buschke–Fischer–Brauer keratoderma

Hereditary keratoderma of Unna-Tost in a patient with atopic dermatitis

Contact Info

Product

Resources

About