Clinical, biological and ultrasonographic remission in a patient with musculoskeletal systemic lupus erythematosus with rituximab

Abstract

Systemic lupus erythematosus (SLE) is a multiorganic autoimmune disease that affects skin, osteoarticular and kidney frequently. Rituximab showed efficacy in treatment of osteoarticular and haematological SLE, but its use has been generalised for renal disease. In our case, we showed efficacy of rituximab in SLE articular disease, showing an ultrasonographic improvement.

Ultrasound evaluation of hand, wrist and foot joint synovitis in systemic lupus erythematosus

“…SLEDAI-2K and ECLAM lack the sensitivity to identify local disease inflammation activity at the joint level because the presence of joint disease without signs of systemic or major organ involvement is not systematically analysed in these composite indices. Additional applications of musculoskeletal US to SLE patients have been recently developed, using this imaging technique in paediatric patients and to monitor biologic therapy [46,47].…”

O transplante de células-tronco hematopoéticas como opção no tratamento de doenças não hematológicas

“…Observa-se também uma grande preocupação em relação à segurança do procedimento, e em vários deles a abordagem é do TCTH versus altas doses de imunossupressão, com o emprego de anticorpos monoclonais com a finalidade de se obter a depleção de células T. 36,37,38 Tumores sólidos O TCTH nos tumores sólidos permanece controverso e discutível. Desde o inicio da década de 90, inúmeros ensaios clínicos foram propostos, principalmente os dirigidos para o tratamento do carcinoma metastático ou inflamatório de mama.…”

Doppler US in rheumatic diseases with special emphasis on rheumatoid arthritis and spondyloarthritis

“…Synovitis and tenosynovitis in the upper and lower extremities have been defined in juvenile patients with SLE (39). US has been also used to define improvement in synovitis in patients undergoing treatment (40).…”