Clinical Biofilms: A Challenging Frontier in Wound Care

Hurlow, Jennifer; Couch, Kara; Laforet, Karen; Bolton, Laura; Metcalf, Daniel; Bowler, Philip G

doi:10.1089/wound.2014.0567

Cited by 121 publications

(81 citation statements)

References 44 publications

(60 reference statements)

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“…Those biofilms provide the hosted bacteria with highly protective environment making them more resistant against any antibiotic treatments [75,144]. Formation of the bacterial films within the wound impairs key healing processes such as the inflammatory immune response, granulation tissue formation, and reepithelialisation of the host's injured tissue [147].…”

Section: Infection Impairs Healing Processes Of the Hostmentioning

confidence: 99%

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Avishai¹,

2017

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Whereas the physiologic wound healing (WH) successfully proceeds through the clearly defined sequence of the individual phases of wound healing, chronic non-healing wounds/ulcers fail to complete the individual stages and the entire healing process. There are many risk factors both modifiable (such as stress, smoking, inappropriate alcohol consumption, malnutrition, obesity, diabetes, cardio-vascular disease, etc.) and non-modifiable (such as genetic diseases and ageing) strongly contributing to the impaired WH. Current statistics demonstrate that both categories are increasingly presented in the populations, which causes dramatic socio-economic burden to the healthcare sector and society at large. Consequently, innovative concepts by predictive, preventive and personalised medicine are crucial to be implemented in the area. Individual risk factors, causality, functional interrelationships, molecular signature, predictive diagnosis, and primary and secondary prevention are thoroughly analysed followed by the expert recommendations in this paper.

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Section: Infection Impairs Healing Processes Of the Hostmentioning

confidence: 99%

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Avishai¹,

2017

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“…Uszkodzony naskórek nie wydziela substancji antyseptycznych oraz ochronnych lipidów, aktywowana zostaje kaskada zapalna, co w efekcie prowadzi do powstania rany. Wnikające bakterie tworzą na ranie niekorzystny biofilm, który jest jednym z czynników opóźniających proces gojenia rany i podwyższających ryzyko infekcji [8].…”

Section: Wpływ Biofilmu Bakteryjnego Na Gojenie Ran Przewlekłychunclassified

“…Biofilm jest to zorganizowana struktura komór-kowa zatopiona w produkowanej przez siebie macierzy [8,9], wykazująca adhezję do powierzchni zarówno biologicznych, jak i abiotycznych. Bakterie tworzące biofilm wydzielają do macierzy biopolimery białkowo-cukrowe chroniące je przed atakiem ze strony układu odpornościowego oraz stosowanymi antybiotykami [10][11][12].…”

Section: Wpływ Biofilmu Bakteryjnego Na Gojenie Ran Przewlekłychunclassified

Innovative methods of biofilm treatment in chronic wounds

Mehrholz¹,

Domagała²,

Zielińska³

et al. 2016

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“…Few antibiotics are available in the market, but the development of resistance by pathogens against particular antibiotic is a common process, thus a high dose of such antibiotic is required [37][38][39][40][41]. Wound healing is a very prevalent phenomenon, but in diabetic wound, the healing process gets delayed due to lowering of several physiological processes [42,43], which ultimately leads to infectious wounds and then delayed healing [44][45][46][47]. Hence, in this study, an ecofriendly approach for biosynthesizing metal nanoparticles has been applied, which is low cost, facilely scaled up, feasible, and may act as better therapeutic agent for wound management.…”

Section: Introductionmentioning

confidence: 99%

Effect of Silver Nanoparticle-Mediated Wound Therapy on Biochemical, Hematological, and Histological Parameters

Chauhan

Shrivastava

Prasad

et al. 2018

Asian J Pharm Clin Res

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Methods: Extraction of Syzygium cumini was done and was used for silver nanoparticle synthesis. The synthesized nanoparticles were characterized by ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy, which confirms the availability of nanosilver particles with marginally spherical morphology. The particles were then carried forward for treating impaired diabetic wounds in Wistar rat models. Regular photography was done and wound healing parameters were monitored throughout the study along with analyzing other parameters such as biochemical, hematological, and histological parameters. Results:The study showed that the sizes of the synthesized nanoparticles are below 100 nm. The results obtained from in vivo studies showed efficient wound healing potential of silver nanoparticles as compared to pre-existing drug povidone-iodine, i.e., the percentage reduction in wound area after therapy is 96.09% in case of biosynthesized silver nanoparticle-treated group, 97.7% reduction in chemically synthesized silver nanoparticle-treated group, 64.28% reduction in case of pre-existing drug povidone-iodine-treated group, 37.5% reduction in case of diabetic control group (diabetic), and 97.5% reduction in normal control group (non-diabetic). Results showed that biosynthesized silver nanoparticles showed less toxicity with respect to liver and kidney functions. Skin histology results showed increased sign of wound healing in biosynthesized silver nanoparticles. Hematology results showed no such variation. Conclusion:The study will help to synthesize new economically viable potential biosynthesized nanoparticles along with providing the approach to develop the medication at nanoscale level.

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Clinical Biofilms: A Challenging Frontier in Wound Care

Cited by 121 publications

References 44 publications

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine

Innovative methods of biofilm treatment in chronic wounds

Effect of Silver Nanoparticle-Mediated Wound Therapy on Biochemical, Hematological, and Histological Parameters

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