Clinical, biochemical and neurobehavioural studies of workers engaged in the manufacture of quinalphos

Srivastava, A. K.; Gupta, B. N.; Bihari, Vipin; Mathur, Neeraj; Srivastava, L.P.; Pangtey, Balram S.; Bharti, R. S.; Kumar, Piyush

doi:10.1016/s0278-6915(99)00123-4

Cited by 56 publications

(43 citation statements)

References 12 publications

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“…The exposure to the excess acetylcholine causes stable acetylcholine receptor triggering, resulting in malfunction of the autonomic, somatic and central nervous systems [1]. A study by Srivastava et al [11] reported that the toxicity of quinalphos on 74 workers during its manufacture, revealed alterations in central nervous system (CNS) function that were manifested as memory, learning, vigilance, and motor deficits, despite having normal acetylcholinesterase activity. Many studies have also been documented about the toxicity of quinalphos and its metabolites (2-hydroxyquinoxaline) on plants and soil microorganisms [12], humans, laboratory animals and several wildlife species including aquatic and terrestrial [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Application of statistical design of experiment with desirability function for the removal of organophosphorus pesticide from aqueous solution by low-cost material

Islam

Sakkas

Albanis

2009

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 99%

Application of statistical design of experiment with desirability function for the removal of organophosphorus pesticide from aqueous solution by low-cost material

Islam

Sakkas

Albanis

2009

Journal of Hazardous Materials

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“…Many studies involving workers exposed to noise have shown alterations in various physiological parameters that not only affect the auditory system but also seem to involve several organs and systems (Sharon, 1990;Dodd et al, 1990;Andren L. et al, 1991;Tomei et al, 1991;Tomei et al, 1992;Srivastava et al, 1994;. ; Tomei et al, 1994;Sokas et al, 1995;Deyanov et al, 1995;Saha et al, 1996;Tomei et al, 1996;Kotseva, 1997;Marciniak et al, 1999;Tomei et al, Downloaded by [Temple University Libraries] at 21:38 01 June 2016 1999).…”

Section: Introductionmentioning

confidence: 99%

Acute experimental exposure to noise and hormonal modifications

Tomei¹,

Ruffino

Tomao³

et al. 2000

Journal of Environmental Science and Health, Part A

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The purpose of this study was to analyse, in healthy volunteers exposed to noise of high intensity, any changes in certain hormonal parameters that might be related to psychological and behavioural effects. The parameters studied were cortisol (CORT), dehydroepiandrosterone-sulphate (DHEA-S), prolactin (PRL), growth hormone (GH), insulin (IRI). Some subjective spontaneously expressed parameters, such as feeling cold, feeling sleepy, being bothered by noise and feeling uneasy, feeling nausea, were also taken into consideration. A significant reduction of cortisol compared to the base values was noted both during exposure to noise and at the end of the stimulus. The DHEA-S values increased compared to the base values during administration of the noise and after exposure had finished. After the end of the noise stimulus, prolactin showed a reduction compared to pre-and post-exposure values. Compared to the basic values, GH diminished both during and after exposure to noise. Insulinaemia showed a significant increase of the value during exposure to noise, both compared with 537

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“…126,137 Most of the reports in the literature deal with repeated exposures to OPs, which are as short as 5 days and are rarely longer than 3 months. 134 Also, almost all the studies used chlorpyrifos or its metabolite chlorpyrifos oxon as OPs pesticides. Animal experiments studying asymptomatic exposure to OPs have pointed various effects on physiological and behavioral functions.…”

Section: Long Term Cns Neurotoxicitymentioning

confidence: 99%

Neurotoxic Effects Associated with Current Uses of Organophosphorus Compounds

Mangas

Vilanova

Estévez

et al. 2016

Journal of the Brazilian Chemical Society

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Organophosphorus compounds (OPs) are a large and diverse class of chemicals that have been synthesized, since the XIX century for several purposes like chemical weapons, flame-retardants, ectoparasiticides and investigational new drugs, but mainly as agrochemicals in agriculture and indoor. Although the amount of OP pesticides being used is declining, especially in developed countries, OPs continue being one of the most important classes of insecticides and chemical warfare agents today due to its toxic effects on the enzyme acetylcholinesterase (AChE). Existing research on the toxicological effects of OPs is extensive, however, there is a lack of knowledge on the long-term effects of low levels of OPs and their exactly pathways of toxicity. Recent data prove that other molecular targets than AChE could be targeted by OPs, triggering these effects. Here these data are reviewed and it is highlighted that the current uses of OPs are producing several neurotoxic effects. It is also shown that, to protect people from possible uses and misuses of OPs, more regulations on OPs are needed. Moreover, more mechanistic studies are needed to completely understand their toxicological interactions and mechanisms of action and to identify the whole group of enzymes that interact with them.

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Clinical, biochemical and neurobehavioural studies of workers engaged in the manufacture of quinalphos

Cited by 56 publications

References 12 publications

Application of statistical design of experiment with desirability function for the removal of organophosphorus pesticide from aqueous solution by low-cost material

Application of statistical design of experiment with desirability function for the removal of organophosphorus pesticide from aqueous solution by low-cost material

Acute experimental exposure to noise and hormonal modifications

Neurotoxic Effects Associated with Current Uses of Organophosphorus Compounds

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