Clinical benefits of interferon beta-1a in relapsing-remitting MS: a phase IV study

Fernández, Óscar; Arbizu, T.; Izquierdo, Guillermo; Martı́nez-Yélamos, Antonio; Gata, J.M.; Luque, Gloria M.; Enrique, Rafael

doi:10.1034/j.1600-0404.2003.01350.x

Cited by 32 publications

(43 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been well documented that the brain goes through pathological changes that closely track the progression of age and cognitive impairment [17]. That is, outcomes that have been shown to be negatively associated with age include but are not limited to brain structure [19], metabolism [40], and cognition [18]. The observed group difference in age (Table 1) suggests that those who did not satisfy peak effort criteria are at a greater risk for cognitive impairment and likely have greater disease associated pathology.…”

Section: Discussionmentioning

confidence: 99%

An Objective Method to Accurately Measure Cardiorespiratory Fitness in Older Adults Who Cannot Satisfy Widely Used Oxygen Consumption Criteria

Dougherty

Lindheimer

Stegner

et al. 2017

JAD

View full text Add to dashboard Cite

Cardiorespiratory fitness (CRF) is routinely investigated in older adults; however, the most appropriate CRF measure to use for this population has received inadequate attention. This study aimed to (i) evaluate the reliability and validity of the oxygen uptake efficiency slope (OUES) as a sub-maximal measurement of CRF, (ii) examine demographic, risk-factor, and exercise testing differences in older adults who satisfied standardized criteria for a peak oxygen consumption (V̇O2peak) test compared to those who did not and (iii) determine the difference between directly measured V̇O2peak values and OUES-predicted V̇O2peak values. One hundred ten enrollees from the Wisconsin Registry for Alzheimer’s Prevention participated in this study. Participants performed a graded maximal exercise test and wore an accelerometer for 7 days. For each participant, the OUES was calculated at 75%, 90% and 100% of exercise duration. V̇O2peak was recorded at peak effort, and one week of physical activity behavior was measured. OUES values calculated at separate relative exercise durations displayed excellent reliability (ICC=.995; p<.001), and were strongly correlated with V̇O2peak (rrange=.801–.909; p<.001). As hypothesized, participants who did not satisfy V̇O2peak criteria were significantly older than those who satisfied criteria (p=.049) and attained a directly measured V̇O2peak that was 2.31 mL·kg·min−1 less than the value that was predicted by OUES V̇O2peak (p=.003). Older adults are less likely to satisfy V̇O2peak criteria, which results in an underestimation of their CRF. Without adhering to standardized criteria, V̇O2peak measurement error may lead to misinterpretation of CRF and age-related associations. Here, we conclude that OUES is a reliable, valid measurement of CRF which does not require achievement of standardized criteria.

show abstract

Section: Discussionmentioning

confidence: 99%

An Objective Method to Accurately Measure Cardiorespiratory Fitness in Older Adults Who Cannot Satisfy Widely Used Oxygen Consumption Criteria

Dougherty

Lindheimer

Stegner

et al. 2017

JAD

View full text Add to dashboard Cite

show abstract

“…5,6 However, IFN-b has only a modest impact on the overall disease progression, and approximately one in three MS patients does not respond at all to the therapy. 36,54,55 Among the manifold immunomodulatory activities of IFN-b described are up-regulation and increased shedding of adhesion molecules, induction of IL-10 and neurotrophic factors, inhibition of matrix metalloproteases, and reduction of cell adhesion to the blood-brain barrier. 7,36,[56][57][58][59][60] Consequently, IFN-b is thought to exert part of its beneficial effect by limiting the transmigration of activated pro-inflammatory T cells across the blood-brain barrier into the CNS.…”

Section: Discussionmentioning

confidence: 99%

Interferon‐β therapy reduces CD4⁺ and CD8⁺ T‐cell reactivity in multiple sclerosis

et al. 2006

View full text Add to dashboard Cite

Summary Therapy with interferon‐β (IFN‐β) has well‐established clinical effects in multiple sclerosis (MS), albeit the immunomodulatory mechanisms are not fully understood. We assessed the prevalence and functional capacity of CD4+ and CD8+ T cells in healthy donors, and in untreated and IFN‐β‐treated MS patients, in response to myelin oligodendrocyte glycoprotein (MOG). The proportion of CD45RO+ memory T cells was higher in MS patients than in healthy donors, but returned to normal values upon therapy with IFN‐β. While CD45RO+ CD4+ T cells from all three groups responded to MOG in vitro, untreated patients showed augmented proliferative responses compared to healthy individuals and IFN‐β treatment reduced this elevated reactivity back to the values observed in healthy donors. Similarly, the response of CD45RO+ CD8+ T cells to MOG was strongest in untreated patients and decreased to normal values upon immunotherapy. Overall, the frequency of peripheral CD45RO+ memory T cells ex vivo correlated with the strength of the cellular in vitro response to MOG in untreated patients but not in healthy donors or IFN‐β‐treated patients. Compared with healthy individuals, responding CD4+ and CD8+ cells were skewed towards a type 1 cytokine phenotype in untreated patients, but towards a type 2 phenotype under IFN‐β therapy. Our data suggest that the beneficial effect of IFN‐β in MS might be the result of the suppression or depletion of autoreactive, pro‐inflammatory memory T cells in the periphery. Assessment of T‐cell subsets and their reactivity to MOG may represent an important diagnostic tool for monitoring successful immunotherapy in MS.

show abstract

“…Normal aging is associated with declines in many cognitive functions including episodic memory, working memory, processing speed and executive functions (Baltes and Lindenberger, 1997; Nilsson, 2003; Park, et al, 2001; Salthouse, 1996), but there is preservation in select cognitive domains such as verbal abilities and world knowledge (Park et al, 2002; Park and Reuter-Lorenz, 2009; Goh et al, 2011; for reviews, see Hedden and Gabrieli, 2004). A key cognitive function that is purported to remain relatively unaffected by age is implicit memory, which involves changes in behavioral performance,--usually facilitation--due to prior stimulus exposure and priming that does not require conscious awareness.…”

Section: Introductionmentioning

confidence: 99%

Neural correlates of conceptual object priming in young and older adults: an event-related functional magnetic resonance imaging study

Ballesteros

Bischof

Goh

et al. 2013

Neurobiology of Aging

View full text Add to dashboard Cite

In this event-related fMRI study, we investigated age-related differences in brain activity associated with conceptual repetition priming in young and older adults. Participants performed a speeded “living/non-living” classification task with three repetitions of familiar objects. Both young and older adults showed a similar magnitude of behavioral priming to repeated objects and evidencing repetition-related activation reductions in fusiform gyrus, superior occipital, middle and inferior temporal cortex, as well as inferior frontal and insula regions. The neural priming effect in young adults was extensive and continued through both the second and third stimulus repetitions, whereas neural priming in older adults was markedly attenuated and reached floor at the second repetition. In young adults, greater neural priming in multiple brain regions correlated with greater behavioral facilitation whereas in older adults, only activation reduction in the left inferior frontal correlated with faster behavioral responses. These findings provide evidence for altered neural priming in older adults despite preserved behavioral priming, and suggest the possibility that age-invariant behavioral priming is observed as a result of more sustained neural processing of stimuli in older adults which may be a form of compensatory neural activity.

show abstract

Clinical benefits of interferon beta-1a in relapsing-remitting MS: a phase IV study

Abstract: This study confirms and extends the beneficial clinical profile for IFNbeta-1a in relapsing MS.

Cited by 32 publications

References 17 publications

An Objective Method to Accurately Measure Cardiorespiratory Fitness in Older Adults Who Cannot Satisfy Widely Used Oxygen Consumption Criteria

An Objective Method to Accurately Measure Cardiorespiratory Fitness in Older Adults Who Cannot Satisfy Widely Used Oxygen Consumption Criteria

Interferon‐β therapy reduces CD4⁺ and CD8⁺ T‐cell reactivity in multiple sclerosis

Neural correlates of conceptual object priming in young and older adults: an event-related functional magnetic resonance imaging study

Contact Info

Product

Resources

About

Clinical benefits of interferon beta-1a in relapsing-remitting MS: a phase IV study

Abstract: This study confirms and extends the beneficial clinical profile for IFNbeta-1a in relapsing MS.

Cited by 32 publications

References 17 publications

An Objective Method to Accurately Measure Cardiorespiratory Fitness in Older Adults Who Cannot Satisfy Widely Used Oxygen Consumption Criteria

An Objective Method to Accurately Measure Cardiorespiratory Fitness in Older Adults Who Cannot Satisfy Widely Used Oxygen Consumption Criteria

Interferon‐β therapy reduces CD4+ and CD8+ T‐cell reactivity in multiple sclerosis

Neural correlates of conceptual object priming in young and older adults: an event-related functional magnetic resonance imaging study

Contact Info

Product

Resources

About

Interferon‐β therapy reduces CD4⁺ and CD8⁺ T‐cell reactivity in multiple sclerosis