Clinical benefit and fragility evaluation of systemic therapy trials for advanced soft tissue sarcoma
Dina Braik,
Christopher Lemieux,
Brooke E. Wilson
et al.
Abstract:BackgroundThe clinical benefit of systemic anticancer therapies can be unclear despite positive trials, and outcomes may not translate to real‐world practice. This study evaluated the benefit of soft tissue sarcoma (STS) treatments using the European Society of Medical Oncology Magnitude of Clinical Benefit Scale (MCBS) v1.1 and measured the robustness of STS trial results using Fragility Index (FI).MethodsDatabase searches for adult phase II or III trials in advanced STS (January 1998–December 2023) were perf… Show more
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