Clinical behaviors of rare variants of papillary thyroid carcinoma are associated with survival: a population-level analysis

Jiang, Chenghao; Cheng, Tao; Zheng, Xucai; Hong, Shikai; Liu, Song; Li, Jianjun; Wang, Jing; Wang, Shengying

doi:10.2147/cmar.s157823

Cited by 35 publications

(27 citation statements)

References 36 publications

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“…Chen et al [54] describe nine cases (five male, four female) of CCV, with a mean age of 57 years. Bongiovanni et al published 11 specimens of FNA cytology (from three Wang et al [55] and Jiang et al [56] have both used the SEER database to demonstrate that CCV is associated with higher rates of extrathyroid extension, nodal and distant metastases, and poorer overall survival in comparison with classic PTC. Average survival in the study by Wang [56], the 10-year overall survival was 89.02% (96.98% in classic PTC; p \ 0.0001).…”

Section: Main Featuresmentioning

confidence: 99%

“…Bongiovanni et al published 11 specimens of FNA cytology (from three Wang et al [55] and Jiang et al [56] have both used the SEER database to demonstrate that CCV is associated with higher rates of extrathyroid extension, nodal and distant metastases, and poorer overall survival in comparison with classic PTC. Average survival in the study by Wang [56], the 10-year overall survival was 89.02% (96.98% in classic PTC; p \ 0.0001). However, in the seminal study by Wenig et al [52], the patients' tumors were divided into encapsulated with minimal invasion and widely infiltrative.…”

Section: Main Featuresmentioning

confidence: 99%

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Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review

et al. 2020

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Introduction: Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant. Methods: We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, and the consequences that the knowledge of these variants should have in the treatment of the patients. Results: At the present time, we do not know the prognostic value of these aggressive PTC variants. The extent of the surgical treatment and adjuvant therapy necessary should be decided on the basis of the extent of the tumor This article was written by members and invitees of the International Head and Neck Scientific Group (https:// www.IHNSG.com).

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Section: Main Featuresmentioning

confidence: 99%

Section: Main Featuresmentioning

confidence: 99%

Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review

et al. 2020

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“…All the current clinical observations suggest the WDTC patient's mortality to increase with age. The explanation of poorer prognosis causes is accompanied by the following facts: the patient group aged 60 years and above to contain a higher male part; these persons have tumors above 5 cm with more frequent metastases rate; their disease is usually attributed to the III-IV stages; it is less probable the patients to be treated by iodine isotope; most probably, these patients anamneses inform about external radiation therapy [5,16,18]. Unsatisfactory therapeutic results in elderly patients are also due to their worsened general condition (and accompanying disorders) as well as to decreased tolerance to the treatment.…”

Section: Resultsmentioning

confidence: 99%

Main Prognostic Factors for Well Differentiated Thyroid Cancer: Analis of Combined Patients Treatment Results during 20 Years after Surgery

Bb¹,

Ae²,

My³

et al. 2018

Thyroid Disorders Ther

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Background: In general, the prognosis in patients with well differentiated thyroid carcinoma (WDTC) is excellent. However, there are small cohorts of patients who experience a more aggressive form of disease which is often associated with certain poor prognostic factors. Identifying these patients at an early stage is imperative for guiding treatment decisions. The purpose of the work is to study the cumulative survival of patients with WDTC, depending on a number of clinical and biological characteristics of tumors. Methods: A retrospective cohort study of patients operated on WDTC in the period from 1995 to 2015 (5526 people). Each patient was analyzed according to age, gender, tumor size and characteristics of the TNM (7 editions), clinical stage, volume of surgery, number of points on the MACIS scale, risk group, number of courses of radioiodine treatment, result treatment and the term of postoperative observation. The construction of cumulative survival curves was made according to the Kaplan-Meier approach. To compare the cumulative survival index value in groups, the non-parametric Log-rank test was used. Results: The most unfavorable factors of the prognosis for patients with WDTC are such integrated indicators as the stage of disease IVb and IVc, as well as tumors of the T4b category. It is also unfavorable to recognize the age of patients over 60 years, the presence of distant metastases, the stage of disease IVa, the category of carcinomas T4a and the size of the tumor more than 40 mm. Other prognostic factors (invasion, multifocal tumor growth, metastasis of carcinoma to the lymph nodes, male sex, post-operative relapse), although they are probable predictive factors, but have somewhat less significance in analyzing the prognosis of survival of patients. Conclusion: Understanding the importance of certain prognostic factors of survival is extremely necessary, since they are the only indicators of the effectiveness of the diagnostic, medical and organizational work will reduce the number of patients who require aggressive treatments and, consequently, increase the duration and quality of their postoperative life.

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“…Among our cohort patients, the worst results have been found for persons above 60 років. All the clinical surveys suggest currently the mortality of patients with differentiated thyroid cancer to grow with age [6,7,13]. While explaining the causes of poorer prognosis, the following facts are to be taken into account.…”

Section: Discussionmentioning

confidence: 99%

Associations between Prognostic Factors Determining the Survival of Thyroid Papillary Carcinoma Patients

Гуда

2019

ijmsci

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Several systems enabling the evaluation of prognosis for patients with differentiated thyroid cancers include, together with some other clinical variables, such ones as patient’s tumor size and age. Associations between these prognostic factors are not yet completely understood; that is why the aim of this investigation was to study the frequency of thyroid papillary carcinoma spreading with different tumor aggressive characteristics depending on patient sex and age as well as on primary neoplasm size. All these three factors are significant for the disease prognosis, their impact being, however, not the same. The results suggest the tumor size as well as patient age and sex to be also essential and to impact on the spreading of tumor characters determining their aggressiveness. The effect of the tumor size differs in patients of different sex and age.

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Clinical behaviors of rare variants of papillary thyroid carcinoma are associated with survival: a population-level analysis

Cited by 35 publications

References 36 publications

Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review

Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review

Main Prognostic Factors for Well Differentiated Thyroid Cancer: Analis of Combined Patients Treatment Results during 20 Years after Surgery

Associations between Prognostic Factors Determining the Survival of Thyroid Papillary Carcinoma Patients

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