Clinical associations of dual-energy X-ray absorptiometry measurement of hand bone mass in rheumatoid arthritis

Measurement of Foot Bone Mineral Density in Rheumatoid Arthritis: Its Application and Clinical Relevance

“…Devlin et al (24) showed correlation between CRP levels, an activity marker, and hand BMD. In our study, there was a negative correlation between right and left foot BMD and ESR.…”

“…Many studies (18,20,(24)(25)(26) have been published about the assessment of BMD in hand and forearm of RA patients. However to our knowledge, there is no study assessing periarticular and/or total foot BMD in RA using the DEXA method.…”

Hand bone mass in rheumatoid arthritis: A review of the literature

“…Online Submissions: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.5312/wjo.v6.i1.106 osteoporosis and is associated with subsequent progressive joint destruction in patients with RA [2][3][4] . Therefore, precise quantification of hand bone loss may predict the severity and progression of joint destruction.…”

“…Among them, DXA can be considered an accurate, repeatable and sensitive method to assess hand bone mineral density (BMD) in early RA [11,12] . Until now, several studies have revealed the correlation of hand BMD with disease activity, functional capacity, radiographic progression or BMD at other sites in patients with RA [3] . A review of the literature documenting the role of hand DXA in the assessment of progression and joint damage in patients with early RA is necessary.…”

“…Two cross-sectional [3,20] and seven longitudinal studies [4,10,23,[26][27][28][29] reported that hand bone loss was significantly related to disease activity which was assessed by Disease Activity Score 28 (DAS-28), swollen joint count, CRP, Ritchie articular index or early morning stiffness in patients with early RA. However, Deodhar et al [13] underscored that hand BMC correlated with disease severity but not with disease activity in their pioneering cross-sectional study.…”