Clinical association to FKBP5 rs1360780 in patients with depression

Abstract

The FKBP5 protein is of importance for the function of the glucocorticoid receptor. The purpose of the present study was to examine the possible association between the different genotypes of rs1360780 in the FKBP5 gene, and clinical symptoms in patients with unipolar depression. Seven hundred eighteen patients and 673 controls from the Danish Psychiatric Biobank were participated. No association was found between any genotype and diagnosis of unipolar depression. It was found that the group of depressed patients with the CC genotype showed significantly earlier start of treatment with medicine, had a significantly greater tendency to be treated with electroconvulsive therapy and showed a significantly higher frequency of family history of depression compared with the combined group of patients with the CT and TT genotypes. The only informations about controls were their sex and that they were recruited from the blood bank. The clinical data were not complete for all patients

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

“…A number of genetic-related factors, genomic regions, polymorphisms, and other related aspects have been examined with respect to depression [ 61 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 ,...…”

Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population

“…FKBP5 has further been suggested to have a dual effect with positive environment. For example, appraisal among psychiatric patients (Cristóbal-Narváez et al 2020 ) has shown an increase in positive responses to the treatment of psychiatric illness and depression (Binder et al 2004 ; Dam et al 2019 ), while other studies have shown contrary findings (Isaksson et al 2016 ; Pérez-Pérez et al 2018 ). Previous knowledge regarding the associations of parenting style, ELS and the FKBP5 gene on depression provides a cogent rationale for evaluating cG × E interaction effects.…”