Clinical aspects, outcome assessment, and management of ankylosing spondylitis and postenteric reactive arthritis

S, van der Linden; D, van der Heijde

doi:10.1097/00002281-200007000-00005

Cited by 32 publications

(11 citation statements)

References 37 publications

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“…In addition to skeletal involvement, extraarticular manifestations such as inflammatory bowel disease, uveitis, and amyloidosis may occur [1]. Until recent 10 years, especially, NSAIDs have been used for treatment.…”

Section: Discussionmentioning

confidence: 99%

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Hearing and cochlear function of patients with ankylosing spondylitis

et al. 2012

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Ankylosing spondylitis (AS) is a chronic systemic inflammatory disorder that primarily affects the spine and sacroiliac joints. Recent studies described audiovestibular impairment in AS patients. The aim of this study was to evaluate the hearing and function of the cochlear system in patients with AS. Thirty-seven AS patients and 20 healthy controls were evaluated prospectively. Otorhinolaryngologic examinations were performed in all patients together with pure tone audiometry, speech discrimination test, tympanometry, and distortion product otoacoustic emission (DPOE). Disease duration, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores, and hematologic findings (CRP and ESR) were also collected. Pure tone audiometry findings of the patients and controls were significantly different in all frequencies (p < 0.01). Speech discrimination scores were also significantly different (p < 0.01). No significant difference was found between DPOE responses of the patients and controls (p > 0.05). There was no correlation between disease duration, BASDAI scores, hematological findings, and audiometry findings (p > 0.05). This study demonstrated that there is an association between AS and hearing loss, but the cochlea is not the main source of hearing loss.

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Section: Discussionmentioning

confidence: 99%

“…The most common symptom is inflammatory back pain that shows the involvement of the spine and sacroiliac joints. The diagnosis of AS depends on the New York criteria: the presence of inflammatory back pain, the restriction of lumber flexion and chest expansion, and radiological findings of sacroileitis [1,2].…”

Section: Introductionmentioning

confidence: 99%

Hearing and cochlear function of patients with ankylosing spondylitis

et al. 2012

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“…Differences in endogenous peptide presentation by HLA-B27 subtypes might be relevant in the disease pathogenesis. HLA associations here possibly involve arthritic peptides and molecular mimicry, but proof that ankylosing spondylitis is an autoimmune disease attributable to cross-reactivity between bacteria and HLA-B27 is still lacking (127). HLA associations also have been reported for peripheral arthropathies associated with IBD.…”

Section: Hla Association Studies and Extraintestinal Manifestations Omentioning

confidence: 91%

Clinical Aspects and Pathophysiology of Inflammatory Bowel Disease

2002

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SUMMARY The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are recognized as important causes of gastrointestinal disease in children and adults. In this review we delineate the clinical manifestations and diagnostic features of IBD. In addition, we summarize important recent advances in our understanding of the immune mediators of intestinal inflammation. This information has led to new therapeutic approaches in IBD. Further, we discuss the considerable data that point to the significance of genetic factors in the development of IBD and the genetic loci which have been implicated through genomewide searches. The commensal bacterial flora also appears to be a critical element, particularly in regards to Crohn's disease, although the precise role of the bacteria in the disease manifestations remains unclear. Current investigations promise to yield fresh insights in these areas.

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“…This form of ReA belongs to the group of spondyloarthropathies (SpA), is triggered by bacteria (which enter the body through the mucosal surfaces) from the genera Campylobacter, Chlamydia, Salmonella, Shigella, and Yersinia, and is clinically associated with oligoarthritis of the lower limbs and sometimes with urethritis and conjunctivitis (203,210).…”

Section: Introductionmentioning

confidence: 99%

HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations

2004

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Current evidence supports the concept that reactive arthritis (ReA) is an immune-mediated synovitis resulting from slow bacterial infections and showing intra-articular persistence of viable, nonculturable bacteria and/or immunogenetic bacterial antigens synthesized by metabolically active bacteria residing in the joint and/or elsewhere in the body. The mechanisms that lead to the development of ReA are complex and basically involve an interaction between an arthritogenic agent and a predisposed host. The way in which a host accommodates to invasive facultative intracellular bacteria is the key to the development of ReA. The details of the molecular pathways that explain the articular and extra-articular manifestations of the disease are still under investigation. Several studies have been done to gain a better understanding of the pathogenesis of ReA; these constitute the basis for a more rational therapeutic approach to this disease

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Clinical aspects, outcome assessment, and management of ankylosing spondylitis and postenteric reactive arthritis

Cited by 32 publications

References 37 publications

Hearing and cochlear function of patients with ankylosing spondylitis

Hearing and cochlear function of patients with ankylosing spondylitis

Clinical Aspects and Pathophysiology of Inflammatory Bowel Disease

HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations

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