Clinical Aspects of Urea Transporters

Ran, Jianhua; Wang, Hongkai; Hu, Tinghai

doi:10.1007/978-94-017-9343-8_12

Cited by 3 publications

(1 citation statement)

References 86 publications

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“…In animal models, long-term UTB deficiency was associated with severe renal dysfunction and structural damage. On the other hand, genetic variations of the SLC14A1 gene were associated with bladder cancer and, some genotypes were associated with higher morbidity, 26 , 27 , 28 , 29 and rejection after renal transplant. 30 However, we did not find any null alleles in CKD patients or controls that could be identified as a risk factor for the disease.…”

Section: Discussionmentioning

confidence: 99%

Lack of association between Kidd blood group system and chronic kidney disease

Capriolli

Visentainer

Sell

2017

Revista Brasileira de Hematologia e Hemoterapia

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BackgroundThe Kidd blood group system has three antigens, Jka, Jkb and Jk3, found on red blood cells and on endothelial cells of the inner lining of blood vessels in the renal medulla. These are known as urea transporter B (UT-B). Researchers have found that individuals carrying the Jk(a − b−) or Jk-null (UT-B null) phenotypes have a lower urine-concentrating capability and risk of severe renal impairment. This study evaluated the distribution of the Kidd phenotypes in patients with chronic kidney disease and a possible association of Kidd antigens with the development of renal disease.MethodsJka and Jkb antigens were phenotyped using the gel column agglutination test (ID-cards Bio-RAD) in 197 patients with chronic kidney disease and 444 blood donors, as the control group. The phenotype and antigen frequencies between patients and controls were evaluated using the Chi-square method with Yates correction and logistic regression after adjustments for gender and age.ResultsNo differences were observed between the Kidd phenotypes frequency distribution between patients with chronic kidney disease and blood donors [Jk(a − b+) = 22.3% and 27.2%; Jk(a + b−) = 30.5% and 24.3%; Jk(a + b+) = 47.25% and 48.4%, respectively].ConclusionThe distribution of Kidd phenotypes found in the studied population is expected for Caucasians; Jka and Jkb antigens and phenotypes were not found to be related to susceptibility for chronic kidney disease.

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Section: Discussionmentioning

confidence: 99%

Lack of association between Kidd blood group system and chronic kidney disease

Capriolli

Visentainer

Sell

2017

Revista Brasileira de Hematologia e Hemoterapia

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Urea Transporters in Health and Disease

Klein

Sands

2020

Studies of Epithelial Transporters and Ion Channels

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Generation and phenotypic analysis of mice lacking all urea transporters

Jiang

Layton

et al. 2017

Kidney International

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Urea transporters (UT) are a family of transmembrane urea-selective channel proteins expressed in multiple tissues and play an important role in the urine concentrating mechanism of the mammalian kidney. UT inhibitors have been identified to have diuretic activity and might be developed as novel diuretics. To determine if functional deficiency of all UTs in all tissues causes physiological abnormality, we established a novel mouse model in which all UTs were knocked out by deleting an 87 kb of DNA fragment containing most parts of Slc14a1 and Slc14a2 genes. Western blot analysis and immunofluorescence confirmed that there is no expression of urea transporter in all-UT-knockout mice. Daily urine output was nearly 3.5-fold higher, with significantly lower urine osmolality, in all-UT-knockout-mice than that in wild-type mice, and urine osmolality was significantly lower. All-UT-knockout mice were not able to increase urinary urea concentration and osmolality after water deprivation, acute urea loading or high protein intake. A computational model that simulated UT knockout mouse models identified the individual contribution of each UT in urine concentrating mechanism. Knocking out all UTs also decreased the blood pressure and promoted the maturation of the male reproductive system. These results revealed that functional deficiency of all UTs caused urea selective urine concentrating defect with little physiological abnormality in extrarenal organs.

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Clinical Aspects of Urea Transporters

Cited by 3 publications

References 86 publications

Lack of association between Kidd blood group system and chronic kidney disease

Lack of association between Kidd blood group system and chronic kidney disease

Urea Transporters in Health and Disease

Generation and phenotypic analysis of mice lacking all urea transporters

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