Clinical Aspects of Treatment Planning in Barotherapy

Kerr, R. C.

doi:10.1111/j.1440-1673.1962.tb01101.x

Cited by 2 publications

(2 citation statements)

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“…Success is less apparent with such conditions as coronary insufficiency, acute vascu-HYPERBARIC TEAM at Duke prepares a patient to be placed in the hyperbaric tank at colla , irial left. Skilled nersonnel are nresent outside and inside the chamber during treatment lar collapse, chronic arterial disease, OCTOBER Cancer therapy combining radiation and hyperbaric oxygen given in small individual chambers seems to be a more beneficial treatment of certain tumors than radiation alone-probably because increased oxygenation of malignant cells increases their susceptibility to irradiation (8).…”

Section: Benefits and Hazardsmentioning

confidence: 99%

Benefits and Hazards

Neelon¹

1964

The American Journal of Nursing

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Section: Benefits and Hazardsmentioning

confidence: 99%

Benefits and Hazards

Neelon¹

1964

The American Journal of Nursing

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“…The oxygen current was recorded for a substantial time with the patient breathing air to ensure that a steady level was maintained, and this value was taken to represent the tumour or tissue P02 level under ambient conditions in air. The patient was then transferred from a trolley to a special mock-up apparatus (simulator) for the radiotherapist and planning technician to delineate the treatment area and irradiation site for beam direction-a procedure occupying 10 to 30 minutes according to the complexity of the field arrangements (Kerr, 1962). Oxygen tension measurements were continuous over this time.…”

Section: Polarographic Methodsmentioning

confidence: 99%

Oxygen Tension in Human Malignant Disease under Hyperbaric Conditions

Jamieson¹,

Brenk²

1965

Br J Cancer

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IT has been shown (Jamieson and van den Brenk, 1963a) that when Yoshida sarcoma was grown as solid tumour in rats and the animals were placed in oxygen at pressures raised to 4 atmospheres absolute there was a rapid rise in oxygen tension in both the normal tissues and the tumour. A polarographic technique was used to measure oxygen tension. In the present study similar measurements have been made of oxygen tension in spontaneous tumours and normal tissues of human patients treated with megavoltage irradiation during their exposure to hyperbaric oxygen. The polarographic technique and the pressure vessel used in these clinical studies have been described previously (Jamieson, 1962;van den Brenk, 1961). Tumour oxygen tension values are of general interest in the study and treatment of neoplastic growth but particularly in relation to the " oxygen effect " in radiosensitivity. Some doubt still exists whether high concentrations of the respired oxygen raise the oxygen tension in large tumours sufficiently to increase their radiosensitivity. Direct measurement of tumour oxygen tensions in vivo under high pressure oxygen exposure in man have been made by Evans and Naylor (1963). Our own studies present further data which have been analysed with a view to assessing the value of the polarographic technique for measurement of tumour PO2 in vivo. MATERIALS AND METHODS Preparation of patientsEach patient was anaesthetised with pentobarbital sodium (Cass, 1962) and a bilateral myringotomy performed before the polarographic electrodes were inserted and the patient pressurised in pure oxygen. Polarographic methodsThe cathodes used were 230, or 330 , diameter gold wire insulated with " posyn ". Before electrodes were inserted into the various tissues and tumours, a bare gold fresh electrode tip was exposed by snipping off the end of each electrode with scissors. The anode for each patient consisted of a Ag/AgCl electrode of large surface area inserted into the oesophagus in its upper third through an oesophageal catheter; 0 6 v was applied to the anode.To place the cathodes into the tumour in the anaesthetised patient, an 18 gauge hypodermic needle with its trocar in position was introduced into the tumour. The trocar was withdrawn and replaced by an electrode wire threaded down the needle and the electrode tip advanced 0 5-1 cm. beyond the needle tip.

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Clinical Aspects of Treatment Planning in Barotherapy

Cited by 2 publications

References 1 publication

Benefits and Hazards

Benefits and Hazards

Oxygen Tension in Human Malignant Disease under Hyperbaric Conditions

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