Clinical Aspects of Manic Episodes After SARS-CoV-2 Contagion or COVID-19

Casale, Antonio Del; Modesti, Martina Nicole; Rapisarda, Ludovica; Girardi, Paolo; Tambelli, Renata

doi:10.3389/fpsyt.2022.926084

Cited by 10 publications

(10 citation statements)

References 54 publications

(76 reference statements)

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“…A review [53] assessed the evidence on COVID-19 infection as a trigger for relapse or for onset of a bipolar disorder. Evidence of manic episodes related to COVID-19 infection was found, and decreased social interaction was identified as one of the possible explanatory mechanisms.…”

Section: Research During the Coronavirus Disease 2019 Pandemicmentioning

confidence: 99%

Loneliness and mood disorders: consequence, cause and/or unholy alliance?

Giacco

2022

Current Opinion in Psychiatry

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Purpose of reviewPeople with persistent depressive disorders and with bipolar disorder are more likely to feel lonely than people in the general population. This evidence update focused on studies in the last 2 years, characterized by the COVID-19 pandemic and consequent social distancing directives. Recent findingsLongitudinal studies identified that people who feel lonely are more likely to become depressed or to experience relapse of mood disorders. There is emerging evidence that feelings of loneliness or mandatory social isolation can precede manic episodes. Hence the relationship between loneliness and mood disorders is complex and bidirectional. Interventions were developed to reduce loneliness in people with mental health problems, including depressive disorders, through cognitive modification and/or supported socialisation. No loneliness-focused interventions have been specifically tailored to people with bipolar disorder. SummaryStudies carried out before and during the COVID-19 pandemic found that feelings of loneliness can be both consequences and precursors of persistent depression and bipolar disorder. Mood symptoms and loneliness have a cumulative negative effect on physical and mental health outcomes. Conceptual overlaps and relations between loneliness and mood symptoms should be clarified in qualitative studies. Theorydriven intervention models should be developed and tested in methodologically robust studies.

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Section: Research During the Coronavirus Disease 2019 Pandemicmentioning

confidence: 99%

Loneliness and mood disorders: consequence, cause and/or unholy alliance?

Giacco

2022

Current Opinion in Psychiatry

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“…There is growing evidence that COVID-19 and psychiatric diagnoses have a complex bidirectional relationship, each acting as an independent risk factor for the other [ 8 ]. A recent review, however, discovered evidence of multiple cases in which a patient with no known past psychiatric history was diagnosed with a first manic episode shortly after the SARS-CoV-2 infection [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…The illness itself has enormous potential to serve as a trigger for an underlying bipolar disorder that is yet to be diagnosed. In the above-mentioned systematic review, almost every patient included had a history of psychiatric illness in a first-degree relative [ 9 ]. Although much is still unknown about bipolar disorder and mania, a strong genetic component has been identified [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

First Manic Episode Following SARS-CoV-2 Infection

Alihsan¹,

Kashfi²,

Roarke³

2023

Cureus

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Since the beginning of the COVID-19 pandemic, there have been reports of neuropsychiatric symptoms following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), most notably mania and psychosis. However, despite the widely reported incidence of psychosis and mania following infection with SARS-CoV-2, a causal link between the virus and these neuropsychiatric symptoms has not been established. A myriad of confounding factors such as underlying psychiatric disorders, personal and family psychiatric histories, substance use, and treatment with steroids all have the ability to obscure a correlation between SARS-CoV-2 and subsequent psychiatric symptoms. Here we present a case of a manic episode in a 40-year-old male following a COVID-19 infection. He had no past psychiatric history, no family psychiatric history, and no history of substance use. This case is unique in that the patient lacks all these typical confounding variables. It should serve as an example of a first-time manic episode following a recent infection with SARS-CoV-2. It may contribute data to future investigations seeking to better elucidate the correlation between SARS-CoV-2 and neuropsychiatric symptoms such as mania.

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“…COVID-19 has been found to be related to cytokine dysregulations, tryptophan metabolism alterations, sleep disorders, and structural changes in the CNS that are similar to BD ( Lorkiewicz and Waszkiewicz, 2022 ). It is suggested that all these changes may trigger or unmask the development of BD ( Lorkiewicz and Waszkiewicz, 2022 , Del Casale et al, 2022 ). In addition, our patient had a severe illness which may be related to the emergence of neuropsychiatric manifestations, which are considered to worsen the prognosis.…”

Section: Discussionmentioning

confidence: 99%