Clinical Aspects of Cryptogenic Hepatocellular Carcinoma.

Koga, Kenshi

doi:10.2739/kurumemedj.45.105

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Although it is not clear which etiology, HBV or alcohol, contributes highly to the development of HCC in these patients, habitual drinking may also be another important etiology in HBsAg(–)/anti‐HBc(+) HCC patients because approximately 59% of the patients in the PB group had a history of habitual drinking. This prevalence was slightly lower than the result in a study from Japan, reporting that 73% of the patients with cryptogenic HCC (negative for both HBsAg and HCV markers) had a history of alcoholic liver disease 12 . However, a high rate of HCV involvement in alcoholic liver diseases was demonstrated after identification of HCV 13,14 .…”

Section: Discussioncontrasting

confidence: 64%

Clinical features of HBsAg‐negative but anti‐HBc‐positive hepatocellular carcinoma in a hepatitis B virus endemic area

Shim

Kim

et al. 2005

J of Gastro and Hepatol

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Backgound:The presence of antibody to the hepatitis B core antigen (anti-HBc) IgG in serum usually means a past infection of the hepatitis B virus (HBV). The clinical characteristics of patients with hepatocellular carcinoma (HCC), who have only a marker for past HBV infection, were investigated. Methods: A total of 565 HCC patients were classified according to their markers for HBV and the hepatitis C virus (HCV). The clinical features and the survival rate of hepatitis B surface antigen (HBsAg)(-)/anti-HBc(+) patients were compared to those of HBsAg(+) patients. Results: Four hundred and three patients were positive for HBsAg (B group, 71.3%), 64 were positive for anti-HCV (11.3%), and 90 were negative for both HBsAg and anti-HCV (N group, 15.9%). In the N group, 71 were positive for anti-HBc (PB group, 12.6% of total patients). The clinical characteristics of the PB group were different from those of the B group: age at diagnosis (60.6 ± 9.6 vs 53.3 ± 10.6 years, P < 0.001), habitual drinking (59.2% vs 23.6%, P < 0.001), family history of liver disease (9.9% vs 38.9%, P < 0.005), detection with periodic screening (28.2% vs 50.4%, P < 0.001), and elevated a-fetoprotein (53.5% vs 76.2%, P < 0.001). In both the PB group and the B group, liver cirrhosis was accompanied by a similar high prevalence (74.6% vs 89.1%). However, there was no significant difference in the cumulative survival rate. Conclusions: The prevalence of HBsAg(-)/anti-HBc(+) HCC is not rare or more common than that of anti-HCV(+) HCC in Korea, a high HBV endemic area. Although some differences in clinical characteristics may imply a different pathogenesis, chronic HBV infection or habitual drinking may be major contributing factors in the development of HCC in these patients.

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Section: Discussioncontrasting

confidence: 64%

Clinical features of HBsAg‐negative but anti‐HBc‐positive hepatocellular carcinoma in a hepatitis B virus endemic area

Shim

Kim

et al. 2005

J of Gastro and Hepatol

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“…One possible explanation is that neutrophils produce a significant amount of circulating vascular endothelial growth factor, which promotes tumor progression and angiogenesis ( 29 ). Previous research has shown that an abnormal HBsAg level may be a signal for poorly differentiated HCCs ( 18 , 30 ). Wu et al ( 31 ) found a close association between AFP levels and poorly differentiated HCCs.…”

Section: Discussionmentioning

confidence: 99%

CT-based radiomics for predicting pathological grade in hepatocellular carcinoma

Huang,

Chen,

Ding

et al. 2024

Front. Oncol.

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ObjectiveTo construct and validate radiomics models for hepatocellular carcinoma (HCC) grade predictions based on contrast-enhanced CT (CECT).MethodsPatients with pathologically confirmed HCC after surgery and underwent CECT at our institution between January 2016 and December 2020 were enrolled and randomly divided into training and validation datasets. With tumor segmentation and feature extraction, radiomic models were constructed using univariate analysis, followed by least absolute shrinkage and selection operator (LASSO) regression. In addition, combined models with clinical factors and radiomics scores (Radscore) were constructed using logistic regression. Finally, all models were evaluated using the receiver operating characteristic (ROC) curve with the area under the curve (AUC), calibration curve, and decision curve analysis (DCA).ResultsIn total 242 patients were enrolled in this study, of whom 170 and 72 formed the training and validation datasets, respectively. The arterial phase and portal venous phase (AP+VP) radiomics model were evaluated as the best for predicting HCC pathological grade among all the models built in our study (AUC = 0.981 in the training dataset; AUC = 0.842 in the validation dataset) and was used to build a nomogram. Furthermore, the calibration curve and DCA indicated that the AP+VP radiomics model had a satisfactory prediction efficiency.ConclusionsLow- and high-grade HCC can be distinguished with good diagnostic performance using a CECT-based radiomics model.

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Clinical Aspects of Cryptogenic Hepatocellular Carcinoma.

Cited by 2 publications

References 22 publications

Clinical features of HBsAg‐negative but anti‐HBc‐positive hepatocellular carcinoma in a hepatitis B virus endemic area

Clinical features of HBsAg‐negative but anti‐HBc‐positive hepatocellular carcinoma in a hepatitis B virus endemic area

CT-based radiomics for predicting pathological grade in hepatocellular carcinoma

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