Clinical Aspects and Treatment of Pityriasis Lichenoides Et Varioliformis Acuta: A Retrospective Vietnamese Study

Van, Thuong Nguyen; Thị, Thủy Nguyễn; Huu, Doanh Le; Huu, Nghi Dinh; Thi, Mai Le; Minh, Thu Nguyen; Huyen, My Le; Gandolfi, Marco; Satolli, Francesca; Feliciani, Claudio; Tirant, Michael; Vojvodić, Aleksandra; Lotti, Torello

doi:10.3889/oamjms.2019.005

Open Access Maced J Med Sci

2019

DOI: 10.3889/oamjms.2019.005

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Clinical Aspects and Treatment of Pityriasis Lichenoides Et Varioliformis Acuta: A Retrospective Vietnamese Study

Thuong Nguyen Van¹,

Thủy Nguyễn Thị²,

Doanh Le Huu³

et al.

Abstract: BACKGROUND:Pityriasis lichenoides et varioliformis acuta (PLEVA) is an uncommon condition which presents acutely with papulo-vesicles that may develop necrotic, ulcerative, or hemorrhagic changes.AIM:We studied clinical, and treatment characteristics of PLEVA hospitalised patients at our hospital from September 2009 to December 2014.METHODS:The records of 15 PLEVA patients were retrospectively reviewed.RESULTS:The median age of onset was 21.8 ± 18.81 (from 1 to 68), male to female ratio was 2/1. The common are… Show more

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Cited by 3 publications

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“…Pityriasis lichenoides (PL) is a rare disease group, consisting of pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta (PLEVA). 1 Here, a case of PLEVA accompanied by Giardia intestinalis, Enterobius vermicularis, and Helicobacter pylori infections is presented, because there is no case associated with intestinal pathogens in the literature.…”

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confidence: 99%

Pityriasis Lichenoides et Varioliformis Acuta Case with Enterobiasis, Giardiasis, and Helicobacter pylori Infection

Melikoğlu,

Solak Esen,

Yamak

et al. 2024

The Eurasian Journal of Medicine

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mentioning

confidence: 99%

Pityriasis Lichenoides et Varioliformis Acuta Case with Enterobiasis, Giardiasis, and Helicobacter pylori Infection

Melikoğlu,

Solak Esen,

Yamak

et al. 2024

The Eurasian Journal of Medicine

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Oral erythromycin in pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta

Chen

Zhao

Xiang

et al. 2020

Dermatologic Therapy

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Pityriasis lichenoides (PL) is an uncommon cutaneous disorder. Oral erythromycin is proposed to be effective in treating the disease. Here, we reported 16 pediatric patients with PL and systematically reviewed published literatures on erythromycin treatment response in pediatric PL patients, to observe the different treatment response to erythromycin in the pityriasis lichenoides chronica (PLC) and the pityriasis lichenoides et varioliformis acuta (PLEVA) groups. Sixteen patients, 8 with PLC and 8 with PLEVA, were treated with erythromycin. In the PLC group, 25% (n = 2) patients responded to erythromycin, while in the PLEVA group, 87.5% (n = 7) patients responded to erythromycin. The response rate was higher in the PLEVA group than the PLC group (P =.05). No side effect was reported in the 16 patients. A total of 34 children including 16 from our studies were included for further descriptive analysis, in which 12 had PLC and 22 had PLEVA. In the PLC group, 41.7% (n = 5) of patients responded to erythromycin while in the PLEVA group, 90.9 % (n = 20) of patients responded. The response rate was higher in the PLEVA group than the PLC group (P = .004). In conclusion, erythromycin is effective and safe in the treatment of children with PL, and erythromycin was more effective in patients with PLEVA than PLC.

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A systematic review of treatments for pityriasis lichenoides

Bellinato

Maurelli

Gisondi

et al. 2019

Acad Dermatol Venereol

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Pityriasis lichenoides (PL) represents a spectrum of inflammatory skin diseases comprising pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC). This study aimed to provide a summary of effective treatments for PL. A systematic review was performed according to PRISMA guidelines for studies investigating PL treatment including ≥3 subjects and published in English between 1 January 1970 and 15 April 2019. A total of 441 papers were screened, and 37 original manuscripts meeting the inclusion and exclusion criteria were found, including 12 case series, 18 reviews, four prospective studies, two comparative studies and a single randomized controlled study. In most studies, ultraviolet (UV) phototherapy (narrow‐band UVB, broadband UVB, UVA1 or PUVA) was used. Clearance rates with the different modalities are hardly comparable between different studies, ranging approximately between 70% and 100%. Narrow‐band UVB showed an efficacy similar to PUVA as such as the combination of UVA and UVB vs. PUVA. Oral erythromycin showed clearance rates ranging between 66% and 83%, whereas methotrexate up to 100% but in small and dated studies. Evidence for other treatments is scarce. There is a lack of high level of evidence studies on PL treatment. The interpretation of the results is biased by the possible auto‐resolution of the disease, the sample heterogeneity between children and adults and the short follow‐up period of the studies. Only some studies investigated how results were durable after cessation of therapy. Quality of life and the impact of treatment were never assessed. According to the results of this review, we suggest narrow‐band UVB phototherapy as first‐line treatment. Oral erythromycin with or without topical corticosteroids and low‐dose methotrexate as second‐line therapies. High‐powered studies and randomized controlled trials are needed to establish the optimal treatment for PL.

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Clinical Aspects and Treatment of Pityriasis Lichenoides Et Varioliformis Acuta: A Retrospective Vietnamese Study

Cited by 3 publications

References 6 publications

Pityriasis Lichenoides et Varioliformis Acuta Case with Enterobiasis, Giardiasis, and Helicobacter pylori Infection

Pityriasis Lichenoides et Varioliformis Acuta Case with Enterobiasis, Giardiasis, and Helicobacter pylori Infection

Oral erythromycin in pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta

A systematic review of treatments for pityriasis lichenoides

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