Clinical aspects and outcomes in osteoarthritis

Tuncay Duruöz, Mehmet; Öz, Nuran; Gürsoy, Didem Erdem; Hande Gezer, Halise

doi:10.1016/j.berh.2023.101855

Cited by 6 publications

(2 citation statements)

References 122 publications

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“…For instance, Osteoarthritis (OA), the most common form of arthritis, frequently presents with symptoms such as joint pain (arthralgia), crepitus (crackling or grinding sensations within the joint), stiffness, and a gradual loss of joint cartilage, which results in joint space narrowing. As OA advances, patients may also experience joint stiffness after rest periods, often called the "gelling phenomenon," and joint effusion due to synovial inflammation [3].…”

Section: Understanding Musculoskeletal Disordersmentioning

confidence: 99%

Orthopedic Applications: Advancing Physiotherapy in Musculoskeletal Health

Sai Sadineni

2024

Physical Therapy - Towards Evidence-Based Practice

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Orthopedic physiotherapy is pivotal in musculoskeletal healthcare, addressing diverse musculoskeletal system conditions. This article provides a comprehensive overview of orthopedic physiotherapy, covering historical evolution, evidence-based principles, diagnostic assessments, therapeutic modalities, exercise prescriptions, post-operative considerations, specialized interventions, technological integration, and patient education. It emphasizes the criticality of evidence-based practice, diagnostic precision, and tailored rehabilitation regimens in achieving optimal patient outcomes. Integrating technology, including advanced imaging modalities and wearable devices, enhances diagnostics, treatment planning, and patient engagement. Patient education and self-management strategies empower individuals to participate in their rehabilitation journey actively. This article underscores the evolving landscape of orthopedic physiotherapy, with ongoing collaboration between clinicians, researchers, and technology reshaping musculoskeletal healthcare.

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Section: Understanding Musculoskeletal Disordersmentioning

confidence: 99%

Orthopedic Applications: Advancing Physiotherapy in Musculoskeletal Health

Sai Sadineni

2024

Physical Therapy - Towards Evidence-Based Practice

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“…Osteoarthritis (OA) is a chronic degenerative joint disease that commonly occurs in elderly individuals, postmenopausal women, athletes, and individuals with metabolic disorders such as diabetes and hyperlipidemia [ 1 , 2 ]. Its clinical manifestations include pain, joint stiffness, swelling, deformity, crepitus, and restricted mobility [ 3 ]. OA not only significantly impacts patients’ quality of life, but also stands as a leading cause of disability in the elderly [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in Stem Cell-Based Therapies in the Treatment of Osteoarthritis

Chen,

Cheng,

et al. 2023

IJMS

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Osteoarthritis (OA) is a chronic, degenerative joint disease presenting a significant global health threat. While current therapeutic approaches primarily target symptom relief, their efficacy in repairing joint damage remains limited. Recent research has highlighted mesenchymal stem cells (MSCs) as potential contributors to cartilage repair, anti-inflammatory modulation, and immune regulation in OA patients. Notably, MSCs from different sources and their derivatives exhibit variations in their effectiveness in treating OA. Moreover, pretreatment and gene editing techniques of MSCs can enhance their therapeutic outcomes in OA. Additionally, the combination of novel biomaterials with MSCs has shown promise in facilitating the repair of damaged cartilage. This review summarizes recent studies on the role of MSCs in the treatment of OA, delving into their advantages and exploring potential directions for development, with the aim of providing fresh insights for future research in this critical field.

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