2001
DOI: 10.2165/00128072-200103080-00004
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Clinical Aspects and Antiviral Therapy in Primary Herpetic Gingivostomatitis

Abstract: Primary symptomatic herpes simplex virus infection in children usually manifests as gingivostomatitis and is prevalent in the 1- to 3-year age group. The disease involves the buccal and gingival mucosa and the tongue, and lasts approximately 2 weeks. Two recent non-blind studies reported a more rapid regression of symptoms after treatment with aciclovir suspension. Three randomised double-blind, placebo-controlled trials have clearly demonstrated that early aciclovir treatment significantly shortens the durati… Show more

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Cited by 42 publications
(21 citation statements)
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“…Primary herpes simplex gingivostomatitis is a self-limiting condition and affected individuals may experience significant mouth pain, fever, and difficulty eating and drinking, as well as being highly infectious 5. Although an approved treatment, retrospective data suggest that aciclovir is used infrequently in the management of this condition 7.…”
Section: Commentarymentioning
confidence: 99%
“…Primary herpes simplex gingivostomatitis is a self-limiting condition and affected individuals may experience significant mouth pain, fever, and difficulty eating and drinking, as well as being highly infectious 5. Although an approved treatment, retrospective data suggest that aciclovir is used infrequently in the management of this condition 7.…”
Section: Commentarymentioning
confidence: 99%
“…Herpetic gingivostomatitis has a peak incidence in the 1-to 3-year age group, and only 13% to 30% of children with primary infection present with symptoms [43]. In contrast, adolescents and adults with primary HSV gingivostomatitis present with painful vesicular lesions that subsequently ulcerate on the buccal surfaces, gingiva, and tongue.…”
Section: Vesiculobullous Gingivostomatitis and Aphthous Ulcersmentioning
confidence: 99%
“…Viral culture from vesicles or rapid enzyme immunoassays for HSV detection helps in making the diagnosis. Antiviral therapy with acyclovir shortens the time to healing in primary herpes labialis in children [43]. Valacyclovir, a prodrug of acyclovir that achieves therapeutic concentrations with longer dosing intervals, may be used as an alternative (Table 1).…”
Section: Vesiculobullous Gingivostomatitis and Aphthous Ulcersmentioning
confidence: 99%
“…The differential diagnosis of primary herpetic gingivostomatitis includes acute necrotizing ulcerative gingivitis, herpangina, aphthous stomatitis, candidiasis of the mouth, Steven-Johnson syndrome and hand, foot and mouth disease (1,5).…”
Section: Introductionmentioning
confidence: 99%
“…herpes encephalitis, neonatal herpes, primary herpes genitals and recurrent herpes labialis) (5). One of the limitations of acyclovir is its poor gastrointestinal absorption and bioavailability and therefore derivatives (e.g.…”
Section: Introductionmentioning
confidence: 99%