Clinical approach to severe Clostridium difficile infection: Update for the hospital practitioner

Pant, Chaitanya; Sferra, Thomas J.; Deshpande, Abhishek; Minocha, Anil

doi:10.1016/j.ejim.2011.04.009

Cited by 19 publications

(14 citation statements)

References 116 publications

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“…For severe CDI and fulminant colitis, however, oral vancomycin is clearly the superior drug as evidenced by both prospective 67,68 and retrospective 69,70 studies. Fidaxomicin, ramoplanin, and tigecycline are newer antibiotics that are effective for the treatment of severe or recurrent disease 71 . Early surgical consultation is recommended for patients with fulminant colitis or patients who fail to respond to medical treatment in a timely fashion 71 .…”

Section: Clostridium Difficilementioning

confidence: 99%

“…Fidaxomicin, ramoplanin, and tigecycline are newer antibiotics that are effective for the treatment of severe or recurrent disease 71 . Early surgical consultation is recommended for patients with fulminant colitis or patients who fail to respond to medical treatment in a timely fashion 71 . In SOT recipients with fulminant colitis, surgical intervention has been reported to result in excellent outcomes 57 .…”

Section: Clostridium Difficilementioning

confidence: 99%

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Diarrhea in solid-organ transplant recipients: a review of the evidence

Pant

Deshpande

Larson

et al. 2013

Current Medical Research and Opinion

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Physicians should be familiar with the common etiologies that result in post-transplant diarrhea. A directed approach to diagnosis and treatment will not only help to resolve the diarrhea but also prevent potentially life-threatening consequences including loss of the graft as well. Prospective studies are required to determine the etiology of post-transplant diarrhea in different clinical and geographic settings.

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Section: Clostridium Difficilementioning

confidence: 99%

Section: Clostridium Difficilementioning

confidence: 99%

Diarrhea in solid-organ transplant recipients: a review of the evidence

Pant

Deshpande

Larson

et al. 2013

Current Medical Research and Opinion

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“…En función de la gravedad, distinguimos tres grados que condicionarán el manejo terapéutico 1,50,53,57 :…”

Section: Clasificación En Función De La Gravedadunclassified

“…No debe realizarse de inicio ante una sospecha de infección, dado que el espectro de afectación de la mucosa colónica es muy amplio y la sensibilidad baja. Se recomienda su realización en los siguientes casos 53,58 : • Alta sospecha clínica y negatividad de los estudios microbiológicos.…”

Section: Endoscopia Anatomía Patológica Y Técnicas De Imagenunclassified

“…También nos sirve para descartar complicaciones como un íleo, una perforación, la presencia de megacolon o incluso una pseudo-obstrucción aguda 74 . En la tomografía computarizada también identificaremos una pared del colon engrosada, y tras la inyección de contraste, el "signo de la diana", en relación con anillos concéntricos con diferentes valores de atenuación debido a hiperemia mucosa y edema submucoso 53,74 . En alguna ocasión se podrá observar alguna pseudomembrana desprendida o engrosamiento nodular.…”

Section: Endoscopia Anatomía Patológica Y Técnicas De Imagenunclassified

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Abordaje multidisciplinario de la infección por Clostridium difficile

Pérez

Hurtado

Couto

et al. 2013

Rev. chil. infectol.

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1‐(1H‐Indol‐3‐yl)ethanamine Derivatives as Potent Staphylococcus aureus NorA Efflux Pump Inhibitors

Héquet¹,

Burchak²,

Jeanty³

et al. 2014

ChemMedChem

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The synthesis of 37 1-(1H-indol-3-yl)ethanamine derivatives, including 12 new compounds, was achieved through a series of simple and efficient chemical modifications. These indole derivatives displayed modest or no intrinsic anti-staphylococcal activity. By contrast, several of the compounds restored, in a concentration-dependent manner, the antibacterial activity of ciprofloxacin against Staphylococcus aureus strains that were resistant to fluoroquinolones due to overexpression of the NorA efflux pump. Structure-activity relationships studies revealed that the indolic aldonitrones halogenated at position 5 of the indole core were the most efficient inhibitors of the S. aureus NorA efflux pump. Among the compounds, (Z)-N-benzylidene-2-(tert-butoxycarbonylamino)-1-(5-iodo-1H-indol-3-yl)ethanamine oxide led to a fourfold decrease of the ciprofloxacin minimum inhibitory concentration against the SA-1199B strain when used at a concentration of 0.5 mg L(-1) . To the best of our knowledge, this activity is the highest reported to date for an indolic NorA inhibitor. In addition, a new antibacterial compound, tert-butyl (2-(3-hydroxyureido)-2-(1H-indol-3-yl)ethyl)carbamate, which is not toxic for human cells, was also found.

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Clinical approach to severe Clostridium difficile infection: Update for the hospital practitioner

Cited by 19 publications

References 116 publications

Diarrhea in solid-organ transplant recipients: a review of the evidence

Diarrhea in solid-organ transplant recipients: a review of the evidence

Abordaje multidisciplinario de la infección por Clostridium difficile

1‐(1H‐Indol‐3‐yl)ethanamine Derivatives as Potent Staphylococcus aureus NorA Efflux Pump Inhibitors

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