Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination

Abstract

The spike protein of SARS-CoV-2 has been found to exhibit pathogenic characteristics and be a possible cause of post-acute sequelae after SARS-CoV-2 infection or COVID-19 vaccination. COVID-19 vaccines utilize a modified, stabilized prefusion spike protein that may share similar toxic effects with its viral counterpart. The aim of this study is to investigate possible mechanisms of harm to biological systems from SARS-CoV-2 spike protein and vaccine-encoded spike protein and to propose possible mitigation strategies. We searched PubMed, Google Scholar, and 'grey literature' to find studies that (1) investigated the effects of the spike protein on biological systems, (2) helped differentiate between viral and vaccine-generated spike proteins, and (3) identified possible spike protein detoxification protocols and compounds that had signals of benefit and acceptable safety profiles. We found abundant evidence that SARS-CoV-2 spike protein may cause damage in the cardiovascular, hematological, neurological, respiratory, gastrointestinal, and immunological systems. Viral and vaccine-encoded spike proteins have been shown to play a direct role in cardiovascular and thrombotic injuries from both SARS-CoV-2 and vaccination. Detection of spike protein for at least 6-15 months after vaccination and infection in those with post-acute sequelae indicates spike protein as a possible primary contributing factor to long COVID. We rationalized that these findings give support to the potential benefit of spike protein detoxification protocols in those with long-term postinfection and/or vaccine-induced complications. We propose a base spike detoxification protocol, composed of oral nattokinase, bromelain, and curcumin. This approach holds immense promise as a base of clinical care, upon which additional therapeutic agents are applied with the goal of aiding in the resolution of postacute sequelae after SARS-CoV-2 infection and COVID-19 vaccination. Large-scale, prospective, randomized, double-blind, placebo-controlled trials are warranted in order to determine the relative risks and benefits of the base spike detoxification protocol.

COVID-19 mRNA Vaccines: Lessons Learned from the Registrational Trials and Global Vaccination Campaign

“…Specific types of PACS can be defined based on the presentation of symptoms [278,279]. Not surprisingly, because of the common denominator between infection and mRNA inoculation (the S-protein), COVID-19 vaccination produces long-term symptoms that share many features with PACS [280,281]. The condition may be triggered by an immune overreaction to the vaccine-generated S-protein [282], which has been shown to persist at least six months after the injection [283].…”

Excess Cardiopulmonary Arrest and Mortality after COVID-19 Vaccination in King County, Washington

“…Hulscher et al found that COVID-19 vaccine-induced myocarditis can most likely result in sudden cardiac death using post-mortem analysis in 28 autopsy cases [20]. COVID-19 mRNA vaccines systemically distribute mRNA via LNPs that encodes for the Spike protein, which has been shown to incite deleterious effects in multiple organ systems and cause fibrinolysis-resistant blood clots [25,26]. Baumeier et al found Spike protein and no nucleocapsid in the myocardium of 15 individuals with COVID-19 vaccine-induced myocarditis [27].…”

Automated microscopic measurement of fibrinaloid microclots and their degradation by nattokinase, the main natto protease

“…Although nattokinase preparations are widely available commercially, and as noted above they are considered to have significant therapeutic value, including in Long COVID [256,257], their exact contents are uncertain, and so we decided that it was best to create and use purified, recombinant material.…”