Clinical Appraisal of the Activity Index as a Measure of Rheumatoid Activity

Lansbury, John

doi:10.1002/art.1780110411

Cited by 31 publications

(5 citation statements)

References 2 publications

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“…The presence of rheumatoid arthritis and the response to treatment are usually judged by various criteria, including clinical observations and measurement of the ESR. 34 The arthritic condition is reported to be associated with anemia 35 as the Hb content is significantly decreased, which may be due to reduced erythrocyte deformability. The reduced deformability leads to a shortening of erythrocyte life span.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity ofCleome gynandraL. on Hematological and Cellular Constituents in Adjuvant-Induced Arthritic Rats

Narendhirakannan

Kandaswamy

Subramanian

2005

Journal of Medicinal Food

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Cleome gynandra L. (cat whiskers) has traditionally been used for the treatment of rheumatic and other inflammatory conditions. In this work, the methanolic extract of the leaves of C. gynandra exhibited significant anti-inflammatory activity in adjuvant-induced arthritic rats. Phytochemical screening was carried out to ascertain the qualitative composition of the leaves. Arthritis was induced by Freund's complete adjuvant. A significant decrease in paw edema with a remarkable increase in body weight was observed following oral administration of the leaf extract (150 mg/kg of body weight). The alterations in hematological and other biochemical parameters were restored to near normal after a treatment period of 30 days. These results demonstrate that the plant extract has no harmful effect and exerts in vivo anti-inflammatory properties against adjuvant-induced arthritis.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity ofCleome gynandraL. on Hematological and Cellular Constituents in Adjuvant-Induced Arthritic Rats

Narendhirakannan

Kandaswamy

Subramanian

2005

Journal of Medicinal Food

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“…Belza [66] defines fatigue as “the enduring, subjective sensation of generalized tiredness or exhaustion (p. 639).” Fatigue is considered a symptom of some chronic pain conditions and is used as an index of disease activity in RA [67]. The absence of fatigue is one of 5 criteria used to document remission of RA [68].…”

Section: Mood Disturbances Associated With Pain and Sleep Disordermentioning

confidence: 99%

Sleep Disturbance and Nonmalignant Chronic Pain: A Comprehensive Review of the Literature

Menefee¹,

Cohen²,

et al. 2000

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Sleep disturbance is an important clinical complaint for individuals with nonmalignant pain conditions. This review is a broad introduction to the literature on sleep disturbance and chronic pain conditions. The article critically reviews studies of sleep disturbance in musculoskeletal pain, arthritis, headache, and fibromyalgia. Current neurobiological hypotheses regarding the pathogenesis of sleep disturbance and chronic pain, common comorbid disorders, and pharmacologic and non-pharmacologic treatments for sleep disturbance are reviewed.

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“…RA activity was evaluated by Lansbury activity index calculated from morning stiffness, erythrocyte sedimentation rate, grip strength, and joint score 19. Patients were evaluated for RA activity at the nearest point before the onset of intractable diarrhoea.…”

Section: Methodsmentioning

confidence: 99%

Intractable diarrhoea associated with secondary amyloidosis in rheumatoid arthritis

Okuda

Takamatsu

Oyama

et al. 1997

Annals of the Rheumatic Diseases

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Objective-To examine the clinical characteristics of intractable diarrhoea associated with secondary amyloidosis in rheumatoid arthritis (RA). Methods-Of 179 RA patients with biopsy confirmed secondary amyloidosis, 24 cases (23 women and one man) with intractable diarrhoea lasting for more than one month were retrospectively evaluated. Results-The mean (SD) duration of diarrhoea was 87 (64) days. Prodromal symptoms of gastrointestinal dysfunction (n = 21) and impaired peristalsis (n = 16) were observed. Laboratory data showed hypoproteinaemia (4.7 (0.85) g/dl) caused by malabsorption or protein loss and high values of C reactive protein (17.0 (9.3) mg/dl). Recurrence of intractable diarrhoea (n = 4) and transition from intractable diarrhoea to other gastrointestinal problems of amyloidosis (ischaemic colitis (n = 2) and intestinal pseudoobstruction (n = 4)) were observed. In 19 patients (25 episodes) the duration of intravenous hyperalimentation at remission (18 episodes) was 68 (52) days. Corticosteroid pulse therapy was administered to 10 patients (11 times) and the time elapsed from the end of corticosteroid pulse therapy to the end of diarrhoea was 18 (14) days. One and five year survival rates after the onset of intractable diarrhoea were 73.4% and 38.9% . Seven of 13 patients (54%) had died as a result of infectious diseases. Conclusion-Intractable diarrhoea associated with secondary amyloidosis in RA is a serious clinical entity and the prognosis is poor. Although it is assumed that intravenous hyperalimentation treatment and corticosteroid pulse therapy are favourable regimens for intractable diarrhoea, the patients should be monitored for possible infectious complications.

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Clinical Appraisal of the Activity Index as a Measure of Rheumatoid Activity

Cited by 31 publications

References 2 publications

Anti-Inflammatory Activity ofCleome gynandraL. on Hematological and Cellular Constituents in Adjuvant-Induced Arthritic Rats

Anti-Inflammatory Activity ofCleome gynandraL. on Hematological and Cellular Constituents in Adjuvant-Induced Arthritic Rats

Sleep Disturbance and Nonmalignant Chronic Pain: A Comprehensive Review of the Literature

Intractable diarrhoea associated with secondary amyloidosis in rheumatoid arthritis

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