Clinical Appraisal of a New Adrenergic Blocking Agent: Effect of Regitine on Digital Blood Flow in Normal Subjects and Patients with Peripheral Arterial Diseases

Abstract

By means of venous occlusion digital plethysmography, the authors have evaluated the peripheral vasodilating effect on normal and diseased arterioles of a new adrenergic blocking agent, Regitine, 2-[-( m -Hydroxy-N- p -tolylanilino)-methyl]-2-imidazoline. Results have been compared with the results of similar studies using Priscoline and indirect body heating to produce vasodilation. The effect of palrenteral Regitine on pulse and blood pressure has been noted as well as the clinical results obtained when this drug was used orally for the treatment of certain forms of peripheral vascular disease.