Clinical Applications of Point-of-Care Testing in Different Conditions

Sumita, Nairo Massakazu; Ferreira, Carlos Ernesto Santos; Martino, Marinês Dalla Valle; França, Carolina Nunes; Faulhaber, Adriana C.L.; Scartezini, Mariléia; Pinho, João Renato Rebello; Dias, Claudia Mazza; Cesar, Katia R.; Pariz, Vitor M; Guerra, João Carlos Campos; Barbosa, Ismar Venâncio; Faulhaber, Marcelo H W; Batista, Marcelo Costa; Andriolo, Adagmar; Mendes, Maria Elizabete; Machado, Antonia M O; Colombini, Marjorie Paris; Slhessarenko, Natasha; Shcolnik, Wilson; Khawali, Cristina; Campana, Gustavo Aguiar; Berlitz, Fernando; Galoro, César Alex de Oliveira

doi:10.7754/clin.lab.2018.171021

Cited by 11 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, 4767 blood samples were collected from patients over twenty years (age between 20 value from cholesterol total value. The evaluation of TG is carried out by a colorimetric enzymatic method using lipoprotein lipase, glycerol kinase, glycerol phosphate oxidase and peroxidase [2][3][4][5][6][7][8][9][10][11][12].…”

Section: Methodsmentioning

confidence: 99%

Brazilian Lipid Cardiovascular Risk Pre and During the Covid 19 Pandemic in Asymptomatic and Severely Affected Groups

Martinez¹

2021

OJCRR

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Brazilian Lipid Cardiovascular Risk Pre and During the Covid 19 Pandemic in Asymptomatic and Severely Affected Groups

Martinez¹

2021

OJCRR

View full text Add to dashboard Cite

show abstract

“…Summarizing the reviewed literature, the benefits of POCTs are numerous: (i) they enable more effective physician-patient communication; (ii) have the potential to shorten TAT and patient pathways in a meaningful way (enabling an immediate diagnosis thus timely therapeutic decisions without the need for multiple rounds of physician-patient meetings or samples sent to a distant laboratory); (iii) they can improve patient adherence, as POCT results are evaluated "in one sitting", thus patients become more involved in the therapeutic decision-making, empowering them, and reducing information asymmetry between the parties; (iv) all these factors lead to a better quality of care (Thompson et al, 2013). There was also a general observation about the ease of use of POCT devices both for medical staff and patients (e.g., taking blood from a fingertip, instead of phlebotomy) as reported by Sumita and his research group in their review about different clinical applications of POCT (Sumita et al, 2018).…”

Section: Facilitatorssupporting Factorsmentioning

confidence: 96%

Roadmap for large-scale implementation of point-of-care testing in primary care in Central and Eastern European countries: the Hungarian experience

Dózsa

Horváth

Cserni³

et al. 2022

Prim Health Care Res Dev

View full text Add to dashboard Cite

Objective: The aim of this study is to give a broad overview of the international best practices regarding the implementation of point-of-care testing (POCT) in primary care (PC) setting and to highlight the facilitators and barriers for widespread national uptake. The study focuses on the managerial and organizational side of POCT, offering a roadmap for implementation as well as highlighting the most important requirements needed to unlock the clinical and economical potential of POCT in the Hungarian healthcare system. Methods: We conducted an English language scoping literature review between January 2012 and June 2021 to assess the recent trends of POCT implementation in developed countries. Our research focuses on the recent publications of several European and Anglo-Saxon countries where POCT utilization is common. In parallel, we reviewed the Hungarian regulatory framework, ongoing governmental legislation, and strategies influencing the POCT dissemination in the Hungarian PC sector. Results: Among the possible POCT usage in PC, we identified several clinically relevant devices and tests (C-reactive protein, urine, blood glucose, D-dimer, prothrombin time) important in screening and early detection of morbidities representing high disease burden. Based on international literature, general practitioners (GPs) are interested in the shortened diagnostic times, portable devices, and better doctor–patient relations made possible by POCT. There are several concerns, however, regarding initial and operational costs and reimbursement, limited scientific evidence about quality and safety, unclear regulations on quality validation of tests, as well as managerial aspects like PC staff training and IT integration at the GP level. Conclusion: As our review highlights, there is considerable interest among GPs to implement POCT as it has the potential to improve quality of care; however, there are many obstacles to overcome before widespread uptake. Further investigation is recommended to elaborate management and quality insurance background and to develop appropriate regulatory framework and financial scheme for GP practices. Preferably this work should involve the local practicing GPs to better tailor the implementation roadmap to country-specific details.

show abstract

“…The quantification of electrolytes, urea, and creatinine is very important for CKD patients. However, the available POCTs for the measurements of these parameters are not currently authorized for home use [ 21 ]. The reason for this is related to possible interference due to the complexity of the creatinine specimen matrix, as well as the haemolysis associated with finger-pricking, which makes a potassium measurement almost impossible via the POCT-associated method [ 84 ].…”

Section: Ckd Management and Available Poctmentioning

confidence: 99%

“…Scientific societies of different countries have published standards for accreditation, which include guidance for users of the technology, key quality requirements for POCTs performance, and measures to guarantee the safety and quality of the test results. The guarantee indicators that could be monitored include the accuracy in patient identification, turnaround time, skills assessment of POCT professionals, sample acceptability for testing, POCT device defects, reporting of critical results, accidents with percutaneous devices, and the ratio of all the patient test results that are correctly transcribed or inserted into a patient’s file [ 20 , 21 ]. Appropriately trained staff need to be carefully supervised in reviewing the results and communicating their concerns regarding the device and patient factors, while ensuring sufficient patient training on the use of their devices.…”

Section: Current Limitations To Locs Spreading In Clinical Settingmentioning

confidence: 99%

Lab on a Chip Device for Diagnostic Evaluation and Management in Chronic Renal Disease: A Change Promoting Approach in the Patients’ Follow Up

et al. 2023

View full text Add to dashboard Cite

Lab-on-a-chip (LOC) systems are miniaturized devices aimed to perform one or several analyses, normally carried out in a laboratory setting, on a single chip. LOC systems have a wide application range, including diagnosis and clinical biochemistry. In a clinical setting, LOC systems can be associated with the Point-of-Care Testing (POCT) definition. POCT circumvents several steps in central laboratory testing, including specimen transportation and processing, resulting in a faster turnaround time. Provider access to rapid test results allows for prompt medical decision making, which can lead to improved patient outcomes, operational efficiencies, patient satisfaction, and even cost savings. These features are particularly attractive for healthcare settings dealing with complicated patients, such as those affected by chronic kidney disease (CKD). CKD is a pathological condition characterized by progressive and irreversible structural or functional kidney impairment lasting for more than three months. The disease displays an unavoidable tendency to progress to End Stage Renal Disease (ESRD), thus requiring renal replacement therapy, usually dialysis, and transplant. Cardiovascular disease (CVD) is the major cause of death in CKD, with a cardiovascular risk ten times higher in these patients than the rate observed in healthy subjects. The gradual decline of the kidney leads to the accumulation of uremic solutes, with negative effect on organs, especially on the cardiovascular system. The possibility to monitor CKD patients by using non-invasive and low-cost approaches could give advantages both to the patient outcome and sanitary costs. Despite their numerous advantages, POCT application in CKD management is not very common, even if a number of devices aimed at monitoring the CKD have been demonstrated worldwide at the lab scale by basic studies (low Technology Readiness Level, TRL). The reasons are related to both technological and clinical aspects. In this review, the main technologies for the design of LOCs are reported, as well as the available POCT devices for CKD monitoring, with a special focus on the most recent reliable applications in this field. Moreover, the current challenges in design and applications of LOCs in the clinical setting are briefly discussed.

show abstract

Clinical Applications of Point-of-Care Testing in Different Conditions

Abstract: We hope to see a global consensus on an acceptable quality standard for performing POCT that is adaptable, practical, and cost effective in primary care settings, ensuring patient safety, and minimizing the risk of harm.

Cited by 11 publications

References 0 publications

Brazilian Lipid Cardiovascular Risk Pre and During the Covid 19 Pandemic in Asymptomatic and Severely Affected Groups

Brazilian Lipid Cardiovascular Risk Pre and During the Covid 19 Pandemic in Asymptomatic and Severely Affected Groups

Roadmap for large-scale implementation of point-of-care testing in primary care in Central and Eastern European countries: the Hungarian experience

Lab on a Chip Device for Diagnostic Evaluation and Management in Chronic Renal Disease: A Change Promoting Approach in the Patients’ Follow Up

Contact Info

Product

Resources

About