Clinical Applications of Physical 3D Models Derived From MDCT Data and Created by Rapid Prototyping

Esses, Steven J.; Berman, Phillip M.; Bloom, Allan I.; Sosna, Jacob

doi:10.2214/ajr.10.5681

Cited by 141 publications

(93 citation statements)

References 10 publications

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“…With recent technical advances AM is nowadays applied to make custom-made implants and surgical tools (175) and to fabricate highly detailed, custom-made three-dimensional models for the indivi-dual patient (using data from CT, MRI, SPECT etc.) to plan surgical approaches, specifically locate osteotomy sites, choose the correct implant and to predict functional and cosmetic outcomes of surgeries (176)(177). Thereby the operating time as well as the risk of complications has been reduced significantly.…”

Section: Additive Manufacturing and Computer Aided Design -Game Changmentioning

confidence: 99%

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

et al. 2013

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The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental "origin" require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.

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Section: Additive Manufacturing and Computer Aided Design -Game Changmentioning

confidence: 99%

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

et al. 2013

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“…Current two-dimensional (2D) imaging technology remains suboptimal for the anatomy and spatial relationships in structural complex heart diseases. RPT is a new digital prototyping technology based on the discrete accumulation-forming principle and the combination of multiple subjects, such as computeraided design, computer numerical control (CNC), laser, and new materials (Esses et al, 2011). Because of its productive agility, highly integrated manufacturing technology, and ability to produce a three-dimensional (3D) entity with any complex shape, RPT has been widely used in the medical field; however, only a few institutions have reported its use in the field of cardiovascular disease (Kim et al, 2008b).…”

Section: Introductionmentioning

confidence: 99%

Clinical application of three-dimensional reconstruction and rapid prototyping technology of multislice spiral computed tomography angiography for the repair of ventricular septal defect of tetralogy of Fallot

Ma¹,

Tao²,

Chen³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Three-dimensional (3D) reconstruction and rapid prototyping technology (RPT) of multislice spiral computed tomography angiography (CTA) was applied to prepare physical models of the heart and ventricular septal defects of tetralogy of Fallot (ToF) patients in order to explore their applications in the diagnosis and treatment of this complex heart disease. CTA data of 35 ToF patients were collected to prepare l:l 3D solid models using digital 3D reconstruction and RPT, and the resultant models were used intraoperatively as reference. The operations of all 35 patients were completed under the guidance of the 3D solid model, without difficulty. Intraoperative findings of the patients were consistent with the morphological and size changes of the 3D solid model, and no significant differences were found between the patches obtained from the 3D solid model and the actual intraoperative measurements (t = 0.83, P = 0.412). 3D reconstruction and RPT of multislice spiral CTA can accurately and intuitively reflect the anatomy of ventricular septal defects in ToF patients, providing the foundation for a solid model of the complex congenital heart.

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“…These advantages generally include higher resolution of the images, lower radiation exposure for the patient, and the availability of additional diagnostic tools depending on the related software packages [12]. Rapid-prototyping techniques are well established in biomedical engineering [13], and there are several different techniques for creating 3D models based on individual datasets. Selective laser sintering (SLS) is a solid freeform fabrication technique that produces models through a selective solidification of a variety of fine powders in a layer-based methodology.…”

Section: Discussionmentioning

confidence: 99%

Craniomaxillofacial surgery planning based on 3D models derived from Cone-Beam CT data

Adolphs

Liu

Keeve

et al. 2013

Computer Aided Surgery

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Introduction: Individual planning of complex maxillofacial corrections may require 3D models which can be manufactured based on DICOM datasets. The gold standard for image acquisition is still high-resolution multi-slice computed tomography (MSCT). However, appropriate datasets for model fabrication can be acquired by modern Cone-Beam CT (CBCT) devices that have been developed specifically for maxillofacial imaging. The clinical utility of individual models fabricated on the basis of CBCT datasets was assessed. Methods: In five patients affected by different deficiencies of the maxillofacial skeleton, preoperative imaging was performed with ILUMA CBCT. Segmentation of hard tissues was performed manually by thresholding. Corresponding STL datasets were created and exported to an industrial service provider (Alphaform, Munich, Germany) specializing in rapid prototyping, and 3D models were fabricated by the selective laser sintering (SLS) technique. For variance analysis, landmark measurements were performed on both virtual and 3D models. Subsequently, maxillofacial surgery was performed according to the model-based planning. Results: All CBCT-based DICOM datasets could be used for individual model fabrication. Detailed reproduction of individual anatomy was achieved and a topographic survey showed no relevant aberrance between the virtual and real models. The CBCT-based 3D models were therefore used for planning and transfer of different maxillofacial procedures. Conclusions: CBCT-based datasets can be used for the fabrication of surgical 3D models if the correct threshold is set. Preoperative workflow and patient comfort is improved in terms of the fast-track concept by using this ''in-house'' imaging technique.

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Clinical Applications of Physical 3D Models Derived From MDCT Data and Created by Rapid Prototyping

Abstract: In recent years, rapid prototyping technologies have provided new possibilities to visualize complex anatomic structures through the generation of physical models that can be used to assist with diagnosis, surgical planning, prosthesis design, and patient communication.

Cited by 141 publications

References 10 publications

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

Clinical application of three-dimensional reconstruction and rapid prototyping technology of multislice spiral computed tomography angiography for the repair of ventricular septal defect of tetralogy of Fallot

Craniomaxillofacial surgery planning based on 3D models derived from Cone-Beam CT data

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