Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging

Shang, Yu; Li, Ting; Yu, Guoqiang

doi:10.1088/1361-6579/aa60b7

Cited by 67 publications

(49 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diffuse correlation spectroscopy (DCS) is emerging as a powerful new tool to assess skeletal muscle perfusion (Gurley et al 2012;Henry et al 2015;Baker et al 2017;Carp et al 2017;Shang et al 2017;Bangalore-Yogananda et al 2018;Hammer et al 2018). DCS is completely non-invasive, has excellent temporal resolution (Bi et al 2015) and has been validated in a variety of organs and tissues against several different standards, including laser Doppler (Shang et al 2011), xenon-CT (Kim et al 2014), fluorescent microsphere flow measurements (Zhou et al 2009) and arterial spin labelled-MRI (Yu et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near‐infrared diffuse correlation spectroscopy

Tucker

Rosenberry

Trojacek

et al. 2019

The Journal of Physiology

View full text Add to dashboard Cite

Key points Diffuse correlation spectroscopy (DCS) is emerging as a powerful tool to assess skeletal muscle perfusion. Near‐infrared spectroscopy (NIRS) is an established technique for characterizing the transport and utilization of oxygen through the microcirculation. Here we compared a combined NIRS–DCS system with conventional measures of oxygen delivery and utilization during handgrip exercise. The data show good concurrent validity between convective oxygen delivery and DCS‐derived blood flow index, as well as between oxygen extraction at the conduit and microvascular level. We then manipulated forearm arterial perfusion pressure by adjusting the position of the exercising arm relative to the position of the heart. The data show that microvascular perfusion can be uncoupled from convective oxygen delivery, and that tissue saturation seemingly compensates to maintain skeletal muscle oxygen consumption. Taken together, these data support a novel role for NIRS–DCS in understanding the determinants of muscle oxygen consumption at the microvascular level. Abstract Diffuse correlation spectroscopy (DCS) is emerging as a powerful tool to assess skeletal muscle perfusion. Combining DCS with near‐infrared spectroscopy (NIRS) introduces exciting possibilities for understanding the determinants of muscle oxygen consumption; however, no investigation has directly compared NIRS–DCS to conventional measures of oxygen delivery and utilization in an exercising limb. To address this knowledge gap, nine healthy males performed rhythmic handgrip exercise with simultaneous measurements by NIRS–DCS, Doppler blood flow and venous oxygen content. The two approaches showed good concurrent validity, with directionally similar responses between: (a) Doppler‐derived forearm blood flow and DCS‐derived blood flow index (BFI), and (b) venous oxygen saturation and NIRS‐derived tissue saturation. To explore the utility of combined NIRS–DCS across the physiological spectrum, we manipulated forearm arterial perfusion pressure by altering the arm position above or below the level of the heart. As expected, Doppler‐derived skeletal muscle blood flow increased with exercise in both arm positions, but with markedly different magnitudes (below: +424.3 ± 41.4 ml/min, above: +306 ± 12.0 ml/min, P = 0.002). In contrast, DCS‐derived microvascular BFI increased to a similar extent with exercise, regardless of arm position (P = 0.65). Importantly, however, the time to reach BFI steady state was markedly slower with the arm above the heart, supporting the experimental design. Notably, we observed faster tissue desaturation at the onset of exercise with the arm above the heart, resulting in similar muscle oxygen consumption profiles throughout exercise. Taken together, these data support a novel role for NIRS–DCS in understanding the determinants of skeletal muscle oxygen utilization non‐invasively and throughout exercise.

show abstract

Section: Introductionmentioning

confidence: 99%

Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near‐infrared diffuse correlation spectroscopy

Tucker

Rosenberry

Trojacek

et al. 2019

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Diffuse correlation spectroscopy (DCS) utilizes photon correlation techniques to noninvasively measure blood flow in deep tissues continuously and at the bedside. [1][2][3][4][5][6] It has been used in a variety of clinical applications, including stroke and muscle disease. Recently, improvements in DCS measurement speed have been exploited to resolve the pulsatile heartbeat fluctuations of arterial blood flow.…”

Section: Introductionmentioning

confidence: 99%

Influence of probe pressure on the pulsatile diffuse correlation spectroscopy blood flow signal on the forearm and forehead regions

Wang

Gao

et al. 2019

Neurophoton.

View full text Add to dashboard Cite

In a pilot study of 11 healthy adults (24 to 39 years, all male), we characterize the influence of external probe pressure on optical diffuse correlation spectroscopy (DCS) measurements of pulsatile blood flow obtained on the forearm and forehead. For external probe pressure control, a hand inflatable air balloon is inserted between the tissue and an elastic strap. The air balloon is sequentially inflated to achieve a wide range of external probe pressures between 20 and 250 mmHg on the forearm and forehead, which are measured with a flexible pressure sensor underneath the probe. At each probe pressure, the pulsatility index (PI) of arteriole blood flow on the forehead and forearm is measured with DCS (2.1-cm source-detector separation). We observe a strong correlation between probe pressure and PI on the forearm (R ¼ 0.66, p < 0.001), but not on the forehead (R ¼ −0.11, p ¼ 0.4). The forearm measurements demonstrate the sensitivity of the DCS PI to skeletal muscle tissue pressure, whereas the forehead measurements indicate that DCS PI measurements are not sensitive to scalp tissue pressure. Note, in contrast to pulsatility, the time-averaged DCS blood flow index on the forehead was significantly correlated with probe pressure (R ¼ −0.55, p < 0.001). This pilot data appears to support the initiation of more comprehensive clinical studies on DCS to detect trends in internal pressure in brain and skeletal muscle.

show abstract

“…Fluctuations in the interference pattern are related to the displacement of red blood cells and can be utilized to compute a blood flow index. Changes in this index from baseline reflect changes in blood flow (Mesquita et al, 2013;Shang et al, 2017), as validated by multiple studies against Doppler ultrasound (Buckley et al, 2012), fluorescent microspheres in piglets (Zhou et al, 2009), and MRI techniques (i.e., arterial spin-labeled perfusion, phase-encoded velocity mapping) (Durduran et al, 2010b;Jain et al, 2014). This study utilized a high-speed variant of DCS, capable of measurement rates of up to 50 Hz (Wang et al, 2016).…”

Section: Measurement Of Cerebral Blood Flow Using Diffuse Correlationmentioning

confidence: 98%

Asymmetric, dynamic adaptation in prefrontal cortex during dichotic listening tasks

Fisher

Gumenchuk

Rogovin

et al. 2019

Preprint

View full text Add to dashboard Cite

Speech comprehension relies on highly distributed, dynamically interconnected neuroanatomical loci. Accordingly, performance on complex speech processing tasks such as dichotic listening can be used to assess the integrity and health of many functional and structural aspects of the brain. Despite the potential merits as a clinical assessment tool, however, the neural substrates activated during dichotic listening remain relatively opaque at higher processing levels. Ultimately, this knowledge gap limits diagnostic use of the task. At the level of the prefrontal cortex, dichotic listening induces an asymmetric response wherein regions on the right hemisphere exhibit a higher functional activation than on the left. Superficially, this finding is counterintuitive given the left hemisphere's dominance for speech and language. To obtain a more in-depth perspective on the potentially distinct roles of the right and left prefrontal cortex, we optically monitored cerebral blood flow in the dorsolateral prefrontal cortex (DLPFC) during dichotic listening tasks in human subjects. The method permitted us to avoid systematic experimental confounds that functional magnetic resonance imaging (fMRI) measurements suffer from, namely the influence of scanner noise. In addition to reproducing the documented larger activation amplitude in the right hemisphere, we also found that repeated listening task blocks were associated with altered kinetics of blood flow in the right, but not the left DLPFC. Interestingly, subjects with the most prominent regional blood flow changes in the right hemisphere also displayed large distortion product otoacoustic emissions (DPOAEs) in the left ear, possibly signaling a correlation between prefrontal activity and top-down listening control infrastructure through medial olivocochlear efferent projections to the inner ear. Overall, our results suggest that the right prefrontal cortical regions play an active role in optimizing task performance.

show abstract

Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging

Cited by 67 publications

References 117 publications

Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near‐infrared diffuse correlation spectroscopy

Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near‐infrared diffuse correlation spectroscopy

Influence of probe pressure on the pulsatile diffuse correlation spectroscopy blood flow signal on the forearm and forehead regions

Asymmetric, dynamic adaptation in prefrontal cortex during dichotic listening tasks

Contact Info

Product

Resources

About