Clinical applications of multi-parametric CMR in myocarditis and systemic inflammatory diseases

Lagan, Jakub; Schmitt, Matthias; Miller, Chris

doi:10.1007/s10554-017-1063-9

Cited by 87 publications

(78 citation statements)

References 115 publications

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“…However, even in the cases without biopsy results, the diagnosis was suggested by the combination of symptoms, laboratory testing, and decreased cardiac function, which often improved after antiviral therapy (see Table 1). While EMB is often performed in heart transplant recipients to rule out rejection, it may not be performed in non–heart transplant recipients, and there is evidence that imaging may have a role in the diagnosis of viral myocarditis 29,30 …”

Section: Discussionsupporting

confidence: 69%

Cytomegalovirus myocarditis in solid organ transplant recipients: A case series and review of literature

Scherger

Mathur

Bajrovic

et al. 2020

Transplant Infectious Dis

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Cytomegalovirus (CMV) is a DNA virus of the Herpesviridae family and is estimated to affect 15%-30% of high-risk solid organ transplant recipients. Typical manifestations of CMV end-organ disease in this population include colitis, esophagitis, and pneumonitis, and myocarditis is a rarely reported manifestation. We describe two cases of CMV myocarditis in solid organ transplant recipients and review the literature regarding previously published cases of CMV myocarditis. K E Y W O R D S cytomegalovirus, solid organ transplant recipients How to cite this article: Scherger S, Mathur S, Bajrovic V, et al. Cytomegalovirus myocarditis in solid organ transplant recipients: A case series and review of literature. Transpl Infect

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Section: Discussionsupporting

confidence: 69%

Cytomegalovirus myocarditis in solid organ transplant recipients: A case series and review of literature

Scherger

Mathur

Bajrovic

et al. 2020

Transplant Infectious Dis

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“…CMR is accurate in describing ventricular morphology and functions well in characterizing cardiac tissue. CMR has a diagnostic accuracy for myocarditis of close to 80% and a negative predictive value of 70% [ 10 ]; T1- and T2-weighted images in addition to late gadolinium enhancement (LGE) improve the final diagnosis [ 11 – 13 ]. Nevertheless, CMR also has limitations: minimal variations can not be detected; borderline myocarditis or cytokine/humoral-mediated forms might not induce injuries to myocytes, thus no LGE can be seen; finally, the time from symptom onset to CMR performance may influence the results.…”

Section: Discussionmentioning

confidence: 99%

Acute Myocarditis After Black Widow Spider Bite: A Case Report

Piscopo¹,

Massari²,

Scicchitano³

et al. 2020

Cardiol Ther

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The black widow spider (BWS) is a venomous spider whose bite can cause various clinical conditions that range from local damage to serious systemic complications, including death. Cases of myocarditis following a BWS bite are rare but they can be fatal on occasion. However, the prognostic significance of the bite and presentation of myocarditis is unknown. Our case involved a 50-year-old man who presented with myocarditis after being bitten by a BWS and subsequently admitted to the intensive care unit for cardiac monitoring. During the hospital stay, he showed worsening signs on both the electrocardiographic and echocardiographic evaluations despite therapeutic success. Subsequent cardiac magnetic resonance and coronary angiography investigations showed no significant alterations; blood and instrumental test results slowly improved, and the patient was discharged home after 12 days of hospitalization without complications. This case illustrates that acute myocarditis, although an infrequent complication of BWS bite, has the potential to be lethal. The correct diagnosis, which is not always easy to formulate, is important to identify those patients who can benefit from careful monitoring and specific therapies aimed at reducing the risk of life.

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“…МРТ считается золотым стандартом, благодаря точности и воспроизводимости оценки показателей объемов, массы и ФВ обоих желудочков, отсутствию радиационной нагрузки. МРТ способствует верификации диагноза миокардита, васкулита, перенесенного инфаркта миокарда, нарушений микроциркуляции и перфузии миокарда, выявлению фиброза миокарда [66][67][68]. Классический протокол МРТ сердца включает в себя [69]:…”

Section: магнитно-резонансная томография сердцаunclassified

Chronic Heart Failure in Rheumatoid Arthritis Patients (Part II): Difficulties of Diagnosis

Новикова¹,

Udachkina²,

Kirillova³

et al. 2019

Racionalʹnaâ farmakoterapiâ v kardiologii

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Rheumatoid arthritis (RA) is characterized by a twofold increase in morbidity and mortality due to chronic heart failure (CHF). At the same time, the prevalence of CHF among RA patients is significantly underestimated. The aim of the review was to analyze the results of the main studies on the features of the clinical presentation of heart failure (HF) in RA patients, the role of visualization techniques and biomarkers in the diagnosis of HF and preclinical dysfunction of the myocardium. HF in patients with RA is characterized by a predominance of HF with a preserved left ventricular ejection fraction (LVEF). The use of clinical diagnostic criteria in RA patients can lead to both over- or underdiagnosis of CHF. Systolic dysfunction estimated by LVEF is rare in RA and does not reflect the real frequency of myocardial dysfunction. Echocardiography (ECHO-CG) with tissue Doppler echocardiography (TDE) and visualization of myocardial deformation, magnetic resonance imaging (MRI) of the heart in RA patients revealed a high frequency of HF with preserved ejection fraction, left ventricular remodeling and hypertrophy, pre-clinical systolic and diastolic dysfunction. Determination of natriuretic peptides is useful for verifying the diagnosis of HF and estimating the prognosis in this cohort, despite the possible decrease in the sensitivity and specificity of these indicators in RA patients. The review discusses the advantages of MRI of the heart, including quantitative T1 and T2 regimens, in the diagnosis of myocarditis, myocardial fibrosis, and myocardial perfusion disorders in RA patients. In order to verify the diagnosis of heart failure and detect pre-clinical myocardial dysfunction in RA patients, the determination of natriuretic peptides concentration should become part of the routine examination, beginning with the debut of the disease, along with the collection of a cardiological history, physical examination, ECHO-CT with TDE, and visualization of myocardial deformation. Evaluation of the quantitative characteristics of tissue according to MRI of the heart could improve the diagnosis of myocardial damage.

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Clinical applications of multi-parametric CMR in myocarditis and systemic inflammatory diseases

Cited by 87 publications

References 115 publications

Cytomegalovirus myocarditis in solid organ transplant recipients: A case series and review of literature

Cytomegalovirus myocarditis in solid organ transplant recipients: A case series and review of literature

Acute Myocarditis After Black Widow Spider Bite: A Case Report

Chronic Heart Failure in Rheumatoid Arthritis Patients (Part II): Difficulties of Diagnosis

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