Clinical Applications of Magnetic Drug Targeting

Lübbe, Andreas S.; Alexiou, Christoph; Bergemann, Christian

doi:10.1006/jsre.2000.6030

Cited by 785 publications

(443 citation statements)

References 24 publications

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“…Once the drug carrier is concentrated at the target, the drug can be released either via enzymatic activity or changes in physiological conditions, such as pH or temperature , and be taken up by the tumor cells. An overview of the clinical applications of magnetic drug targeting was given by Lubbe et al (2001). Larger particles with dimension> lm, comprising agglomerates of superparamagnetic particles, were shown to be more effective in withstanding flow dynamics within the circulatory system.…”

Section: Drug Targetingmentioning

confidence: 99%

Magnetic bead handling on-chip: new opportunities for analytical applications

Gijs

2004

Microfluid Nanofluid

496

555

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This review describes recent advances in the handling and manipulation of magnetic particles in microfluidic systems. Starting from the properties of magnetic nanoparticles and microparticles, their use in magnetic separation, immuno-assays, magnetic resonance imaging, drug delivery, and hyperthermia is discussed. We then focus on new developments in magnetic manipulation, separation, transport, and detection of magnetic microparticles and nanoparticles in microfluidic systems, pointing out the advantages and prospects of these concepts for future analysis applications.

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Section: Drug Targetingmentioning

confidence: 99%

Magnetic bead handling on-chip: new opportunities for analytical applications

Gijs

2004

Microfluid Nanofluid

496

555

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“…[620] A magnetic field strength of 0.8 was provided in tumors located near the body surface by using properly arranged permanent magnets to concentrate the resulting ferrofluid in the target regions. [621] In addition to all these developments, exploiting the stimuli-responsive systems allows for tailored release profiles with excellent spatial, temporal, and dosage control (Figure 35). Specifically, by recognizing their microenvironment, they enable on-demand processes (also termed as "switch on/off") and react in a dynamic way, which in turn mimic the responsiveness of living organisms.…”

Section: Magnetic Drug Targetingmentioning

confidence: 99%

“…[668,670] One problem is associated with the considerable hydrodynamic force generated by high blood velocities in the vascular system [668] which is the only significant force that should be overcome to prevent adverse hydrodynamic conditions on accumulation of MNPs at the target zone. [671] Even in the most favorable situation that the magnetic source is located close to the target zone, which is rarely the case, [621] the drag force exerted on the particles by the blood flow may dominate the magnetic force. [672] Another important problem is the inherent tendency of magnetic fields to be homogeneous over the target zone, which results in very small magnetic field gradients that makes it difficult to collect appreciable amounts of drugs in that region.…”

Section: Implant Assisted Magnetic Drug Targeting (Ia-mdt)mentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…This is not necessarily an advantage for magnetophoretic-based applications such as drug delivery. 54 Thus, one might want to create a system which can be strongly magnetized on the one hand, and be spatially isotropic on the other.…”

Section: Introductionmentioning

confidence: 99%

Microstructure and magnetic properties of magnetic fluids consisting of shifted dipole particles under the influence of an external magnetic field

Weeber

Klinkigt²,

Kantorovich³

et al. 2013

The Journal of Chemical Physics

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Articles you may be interested inTheory of magnetic fluid heating with an alternating magnetic field with temperature dependent materials properties for self-regulated heating J. Appl. Phys. 105, 07B324 (2009) We investigate the structure of a recently proposed magnetic fluid consisting of shifted dipolar (SD) particles in an externally applied magnetic field via computer simulations. For standard dipolar fluids the applied magnetic field usually enhances the dipole-dipole correlations and facilitates chain formation whereas in the present system the effect of an external field can result in a break-up of clusters. We thoroughly investigate the origin of this phenomenon through analyzing first the ground states of the SD-particle systems as a function of an applied field. In a second step we quantify the microstructure of these systems as functions of the shift parameter, the effective interaction parameter, and the applied magnetic field strength. We conclude the paper by showing that with the proper choice of parameters, it is possible to create a system of SD-particles with highly interacting magnetic particles, whose initial susceptibility is below the Langevin susceptibility, and which remains spatially isotropic even in a very strong external magnetic field. © 2013 AIP Publishing LLC.

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Clinical Applications of Magnetic Drug Targeting

Cited by 785 publications

References 24 publications

Magnetic bead handling on-chip: new opportunities for analytical applications

Magnetic bead handling on-chip: new opportunities for analytical applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Microstructure and magnetic properties of magnetic fluids consisting of shifted dipole particles under the influence of an external magnetic field

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