Clinical applications of laser speckle contrast imaging: a review

Heeman, Wido; Steenbergen, Wiendelt; Dam, Gooitzen M. van; Boerma, E. Christiaan

doi:10.1117/1.jbo.24.8.080901

Cited by 206 publications

(154 citation statements)

References 122 publications

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“…LSCI as a technique is a lot more recent and has so far only been used in a few studies with human patients [56][57][58][59][60][61]. During the last 5 years, LSCI has however received increasing attention and is now being used more and more within different areas.…”

Section: Summary Of Current Perfusion Research In Burnsmentioning

confidence: 99%

“…During the last 5 years, LSCI has however received increasing attention and is now being used more and more within different areas. So far, LSCI has seen little use in human burn research [61]. Most studies using LSCI have so far been animal studies, and most studies in human patients ever published are contained within this thesis.…”

Section: Summary Of Current Perfusion Research In Burnsmentioning

confidence: 99%

“…There are however several aspects of LSCI which are still being developed. One of the most promising aspects is the multiexposure LSCI which uses different exposure times to draw further conclusions about the analyzed tissue [61].…”

Section: Summary Of Current Perfusion Research In Burnsmentioning

confidence: 99%

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Blood Flow Dynamics in Burns

Mirdell

2019

Linköping University Medical Dissertations

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Burns of intermediate thickness are hard to evaluate clinically. This often leads to unnecessary delays of up to 14 days before a surgical decision can be made. To counter this, several objective methods have been developed to determine the healing potential of the wound. Over the years, measurement of perfusion has proven to be the most successful method for evaluation of healing potential. Laser Doppler imaging (LDI) is currently the most used method and can determine surgical need 2 days after injury with an accuracy >90%. There are however emerging techniques like laser speckle contrast imaging (LSCI), which also measure perfusion. LSCI have several advantages over LDI and is easier to use. LSCI can also investigate aspects of the microcirculation, previously not possible with LDI. The aim of this thesis was to investigate LSCI's ability to evaluate surgical need in burns of indeterminate partial-thickness. The first objective was to investigate the dynamics of perfusion the first 14 days after injury. The purpose was to find the optimal time-window for perfusion measurements. The next goal was to determine the accuracy of different perfusion cutoffs. In this second study, the benefit of a subsequent measurement was also investigated. After this, interobserver variation between different profession groups was studied. Both the agreement of perfusion measurements and observer assessments were evaluated. Finally, cardiac vasomotion in combination with perfusion (pulsatility) was investigated as a method to determine surgical need <48 hours after injury. Methods:

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Section: Summary Of Current Perfusion Research In Burnsmentioning

confidence: 99%

Section: Summary Of Current Perfusion Research In Burnsmentioning

confidence: 99%

See 1 more Smart Citation

Blood Flow Dynamics in Burns

Mirdell

2019

Linköping University Medical Dissertations

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“…Thus, when the particle moves within the tissue, provokes a variation in this speckle display causing the blurring of speckle patterns. 3 When the variations are triggered by the moving red blood cells (RBCs), this blurring can be accompanied by the blood flow. Starting as a slow, analog research tool, LSCI systems nowadays have gained rapid popularity to record blood flow in (near) real-time.…”

Section: Introductionmentioning

confidence: 99%

The use of laser speckle contrast imaging in clinical applications

2020

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<p class="abstract">Laser speckle contrast imaging (LSCI) is a useful device which is recruited for visualizing full-field microcirculatory images. The speckle pattern is produced as a consistent light illuminates a rough object, and the backscattered radiation is transformed into images and be shown on a screen. Movement within the object results in the fluctuation of patterns over time. Similar information can be attained by employing the Doppler effect, which needs to be scanned again. However, LSCI renders similar data without any further scanning procedure. Nowadays, LSCI has gained expanded consideration, in part because of its accelerated adoption for blood flow studies in the different surgical departments. Here we represent and review the application of LSCI methods of visualizing the field of microcirculation as medical applications from different clinical aspects and discuss the drawbacks that hinder its approval clinically.</p>

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“…Thus, when the particle moves within the tissue, provokes a variation in this speckle pattern causing the blurring of speckle patterns. 3 When the variations are triggered by the moving red blood cells (RBCs), this blurring can be accompanied by the blood flow. Starting as a slow, analog research tool, LSCI systems nowadays have gained rapid popularity to record blood flow in (near) real-time.…”

Section: Introductionmentioning

confidence: 99%

A review of the clinical applications and performance of laser speckle contrast imaging

et al. 2020

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<p class="abstract">Laser speckle contrast imaging (LSCI) is a useful tool for visualizing full-field blood flow images. Speckle pattern is formed when a coherent light illuminates a rough object, and the backscattered radiation is transformed into images and be shown on a screen. Movement within the object results in the fluctuation of patterns over time. The same data can be obtained by employing the Doppler effect, yet producing a two-dimensional Doppler map needs scanning; speckle imaging renders the same information without the requirement to scan. Nowadays, LSCI has gained expanded consideration, in part because of its accelerated adoption for blood flow studies in the different surgical departments. Here we represent and review the application of laser speckle contrast methods to the field of perfusion visualization as clinical studies from various medical fields and discuss the limitations hindering clinical acceptance.</p>

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Clinical applications of laser speckle contrast imaging: a review

Cited by 206 publications

References 122 publications

Blood Flow Dynamics in Burns

Blood Flow Dynamics in Burns

The use of laser speckle contrast imaging in clinical applications

A review of the clinical applications and performance of laser speckle contrast imaging

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