Clinical Applications of End-to-Side Neurorrhaphy: An Update

Tos, Pierluigi; Colzani, Giulia; Ciclamini, Davide; Titolo, Paolo; Pugliese, Pierfrancesco; Artiaco, Stefano

doi:10.1155/2014/646128

Cited by 38 publications

(33 citation statements)

References 48 publications

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“…The regulation of matrix metalloproteinase (MMP) expression and activity [20] as well as neurotrophic factors (TIMPs and IGF) [12,40] might also have very important roles in this process. Recent experimental studies have shown that physical and chemical agents stimulate nerve regeneration after end-toside coaptation, including phototherapy, FK506, and acetyl-L-carnitine [13,24,32,57].…”

Section: Discussionmentioning

confidence: 99%

Collateral sprouting axons of end-to-side nerve coaptation in the avulsion of ventral branches of the C5-C6 spinal nerves in the brachial plexus

Reichert

Kiełbowicz²,

Dzięgiel³

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Collateral sprouting axons of end-to-side nerve coaptation in the avulsion of ventral branches of the C5-C6 spinal nerves in the brachial plexus

Reichert

Kiełbowicz²,

Dzięgiel³

et al. 2015

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“…Sensory axons will spontaneously sprout from the healthy into the injured nerve, providing a kind of protective sensation, although it is never fully normal [11,65,66]. Meanwhile, donor nerve motor axons need an injury (crush or axotomy) to sprout inside an end-to-side coapted damaged nerve [66,69]. It can be useful for sensory nerves but not for motor ones.…”

Section: End-to-end Anastomosismentioning

confidence: 99%

Nerve Transfers in the Treatment of Peripheral Nerve Injuries

Vanaclocha‐Vanaclocha¹,

Ortiz-Criado²,

NievesSáiz-Sapena³

et al. 2017

Peripheral Nerve Regeneration - From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies Deve

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Successful re-innervation of proximal limb peripheral nerve injuries is rare. Axons regenerate at ~1 mm/day, reaching hand muscles by 24 months, finding them atrophied and fibrosed. Peripheral nerve injury repair is often delayed waiting for spontaneous recovery. This waiting time should not be longer than 6 months as after 18 months reinnervation will not achieve effective muscular function. When spontaneous recovery is impossible, referral too late or damage too severe, other options like a transfer from a nearby healthy nerve to the injured one must be considered. They are very successful, and the deficit in the donor site is usually minimal. The most common nerve transfers are a branch of the spinal nerve to the trapezius muscle to the suprascapular nerve, a branch of the long head of the triceps to the axillary nerve, a fascicle of the ulnar nerve to the motor branch of the biceps muscle, two branches of the median nerve to the posterior interosseous nerve and the anterior interosseous nerve to the ulnar nerve. There are many more options that can suit particular cases. Introduced in brachial plexus injury repair, they are now also applied to lower limb, to stroke and to some spinal cord injuries.

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“…[ [26][27][28][29][30] The authors of the current study intend to study the usefulness of this procedure in the scenario of acute trauma of the upper limb by creating nerve bridges at the wrist crease in order to ameliorate ulnar nerve injury, as it has been found that intrinsic muscle function tends to be compromised despite the efforts of a primary end-to-end repair.…”

Section: ]mentioning

confidence: 99%