Clinical Applications of a Stem Cell Based Therapy for Oral Bone Reconstruction

McAllister, Bradley S.; Haghighat, Kamran

doi:10.1142/9789814317061_0014

Cited by 1 publication

(1 citation statement)

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“…A 1‐cc graft of adult marrow from an iliac crest yields ≈1,000 to 1,500 mesenchymal stem cells 19 . Quality testing is performed on every lot of osteoprogenitor cells †† to confirm a minimum cell count of 50,000 cells/cc and a minimum cellular viability of 70% of the enzymatically released cells 20 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Allogenic Cellular Bone Graft for Ridge Augmentation: A Case Report

Sindler

Behmanesh

Reynolds

2013

Clin Adv Periodontics

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Introduction: The reconstruction of alveolar bone defects is often necessary to support successful implant therapy. Although multiple technologies are available to achieve ridge augmentation, the most widely used approaches combine an acellular graft material with guided bone regeneration. Recent advances in tissue banking make it possible to preserve mesenchymal stem cells and osteoprogenitor cells as part of an allogeneic cellular bone matrix that can further enhance the ability of the graft material to provide optimal results for ridge augmentation. Case Presentation: This case report describes the clinical application and results of an allogenic bone matrix product retaining mesenchymal stem and osteoprogenitor cells for alveolar ridge augmentation before implant rehabilitation. The cellular bone matrix supported a radiographic gain of 4 to 6 mm in horizontal ridge width, permitting the placement of dental implants without secondary augmentation. Conclusion: Cellular bone matrix appears to provide an important clinical alternative to acellular bone replacement grafts, particularly in light of its potential to achieve substantial gains in bone volume.

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Section: Discussionmentioning

confidence: 99%