“…As such, we remind that each PEF-based approach has been described in more detail elsewhere [14,78,214,[263][264][265], and systematic reviews on their efficacy are also available [78,80,83,152,162,177,188,210,214,255]. Now, the current challenges pertain to refining treatment indications, individuating the most advantageous timing of treatment application, modulation of treatment intensity (e.g., pulse parameters, number of applications, drug doses, treatment frequency), selection of the target lesions (e.g., primary tumour or distant metastases), and development of combined strategies with local therapies or systemic treatment such as checkpoint inhibitors [248,266]. These issues represent a matter of debate at MDT meetings, where the treatment decision-making still lacks essential information.…”