Clinical Application of Shear Wave Elastography in Breast Masses

Chang, Jane; Moon, Jai‐Hee; Koh, Sung Hye; Park, Sunyoung; Lee, Kwan Seop

doi:10.5812/iranjradiol.39585

Cited by 3 publications

(3 citation statements)

References 28 publications

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Section: Data Availability Statementmentioning

confidence: 98%

“…I would like to acknowledge that the content of the manuscript has previously appeared online in a thesis ( 65 ) and been presented in a conference ( 66 ). I would also like to acknowledge the neurosurgeons at the Great Ormond Street Hospital (Messrs William Harkness, Dominic Thompson, Owase Jeelani, and Kristian Aquilina) and the National Hospital for Neurology and Neurosurgery (Messrs Andrew McEvoy, Lewis Thorne, George Samandouras, Robert Bradford, Andrew McEvoy, and Miss Anna Miserocchi) for their assistance.…”

Section: Acknowledgmentsmentioning

confidence: 99%

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Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection

et al. 2021

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BackgroundThe clinical outcomes for brain tumor resection have been shown to be significantly improved with increased extent of resection. To achieve this, neurosurgeons employ different intra-operative tools to improve the extent of resection of brain tumors, including ultrasound, CT, and MRI. Young’s modulus (YM) of brain tumors have been shown to be different from normal brain but the accuracy of SWE in assisting brain tumor resection has not been reported.AimsTo determine the accuracy of SWE in detecting brain tumor residual using post-operative MRI scan as “gold standard”.MethodsThirty-four patients (aged 1–62 years, M:F = 15:20) with brain tumors were recruited into the study. The intraoperative SWE scans were performed using Aixplorer® (SuperSonic Imagine, France) using a sector transducer (SE12-3) and a linear transducer (SL15-4) with a bandwidth of 3 to 12 MHz and 4 to 15 MHz, respectively, using the SWE mode. The scans were performed prior, during and after brain tumor resection. The presence of residual tumor was determined by the surgeon, ultrasound (US) B-mode and SWE. This was compared with the presence of residual tumor on post-operative MRI scan.ResultsThe YM of the brain tumors correlated significantly with surgeons’ findings (ρ = 0.845, p < 0.001). The sensitivities of residual tumor detection by the surgeon, US B-mode and SWE were 36%, 73%, and 94%, respectively, while their specificities were 100%, 63%, and 77%, respectively. There was no significant difference between detection of residual tumor by SWE, US B-mode, and MRI. SWE and MRI were significantly better than the surgeon’s detection of residual tumor (p = 0.001 and p < 0.001, respectively).ConclusionsSWE had a higher sensitivity in detecting residual tumor than the surgeons (94% vs. 36%). However, the surgeons had a higher specificity than SWE (100% vs. 77%). Therefore, using SWE in combination with surgeon’s opinion may optimize the detection of residual tumor, and hence improve the extent of brain tumor resection.

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Section: Data Availability Statementmentioning

confidence: 98%

Section: Acknowledgmentsmentioning

confidence: 99%

Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection

et al. 2021

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“…Real time strain elastography is a new technique which can assess tissue elasticity by manual compression and decompressions. Many papers which report the efficiency of elastography for solid lesions of breast [5], placenta [6] and salivatory glands [7] are available in the literature also for renal lesions [8,9]. In this prospective study we aimed to investigate the diagnostic performance of real time sonoelastography for evaluation of solid renal masses.…”

Section: Introductionmentioning

confidence: 99%

Real time strain elastography for differentiation of solid renal masses

Tezcan¹

2020

J Clin Med Kaz

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The aim of this study was to investigate the diagnostic performance of real time strain elastography for evaluation of solid renal masses.Material and methods: Forty two patients who were incidentally detected solid renal masses underwent Real Time Strain Elastography. Strain index value was detected for each lesion by dividing ROI of lesion to ROI of adjacent renal cortex. Strain index values and color encoding patterns of lesions and renal parenchyma were obtained. Mean strain index values and color encoding patterns for benign and malignant lesions were compared. Also by using ROC curve, cut-off value was obtained and diagnostic performance of method was evaluated.Results: Any statistically significant difference of mean ages of patients was not found. Mean strain index value of malignant lesions were significantly higher than benign lesions. When cut-off value for strain index ratio was taken 0.3, high diagnostic performance was obtained for differentiation of solid renal masses as benign or malignant. Conclusion:Real time strain elastography can be useful for differentiation of solid renal masses as malignant or benign.

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Comparative Diagnostic Accuracy of Contrast-Enhanced Ultrasound and Shear Wave Elastography in Differentiating Benign and Malignant Lesions: A Network Meta-Analysis

Huang

Jiang

Xu³

et al. 2019

Front. Oncol.

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Background: We performed a network meta-analysis to compare the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) and shear wave elastography (SWE) in differentiating benign and malignant lesions in different body sites.Methods: A computerized literature search of Medline, Embase, SCOPUS, and Web of Science was performed using relevant keywords. Following data extraction, we calculated sensitivity, specificity, positive likelihood ratio (LR), negative LR, and diagnostic odds ratio (DOR) for CEUS, and SWE compared to histopathology as a reference standard. Statistical analyses were conducted by MetaDiSc (version 1.4) and R software (version 3.4.3).Results: One hundred and fourteen studies (15,926 patients) were pooled in the final analyses. Network meta-analysis showed that CEUS had significantly higher DOR than SWE (DOR = 27.14, 95%CI [2.30, 51.97]) in breast cancer detection. However, there were no significant differences between CEUS and SWE in hepatic (DOR = −6.67, 95%CI [−15.08, 1.74]) and thyroid cancer detection (DOR = 3.79, 95%CI [−3.10, 10.68]). Interestingly, ranking analysis showed that CEUS achieved higher DOR in detecting breast and thyroid cancer, while SWE achieved higher DOR in detecting hepatic cancer. The overall DOR for CEUS in detecting renal cancer was 53.44, 95%CI [29.89, 95.56] with an AUROC of 0.95, while the overall DOR for SWE in detecting prostate cancer was 25.35, 95%CI [7.15, 89.89] with an AUROC of 0.89.Conclusion: Both diagnostic tests showed relatively high sensitivity and specificity in detecting malignant tumors in different organs. Network meta-analysis showed that CEUS had higher diagnostic accuracy than SWE in detecting breast and thyroid cancer, while SWE had higher accuracy in detecting hepatic cancer. However, the results were not statistically significant in hepatic and thyroid malignancies. Further head-to-head comparisons are needed to confirm the optimal imaging technique to differentiate each cancer type.

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Clinical Application of Shear Wave Elastography in Breast Masses

Abstract: Background: Quantitative shear wave elastography (SWE) has been developed and utilized to aid in the differentiation between benign and malignant breast lesions based on their stiffness.

Cited by 3 publications

References 28 publications

Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection

Clinical Application of Shear Wave Elastography for Assisting Brain Tumor Resection

Real time strain elastography for differentiation of solid renal masses

Comparative Diagnostic Accuracy of Contrast-Enhanced Ultrasound and Shear Wave Elastography in Differentiating Benign and Malignant Lesions: A Network Meta-Analysis

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