Clinical application of serum biomarkers for detecting and monitoring of chronic plaque psoriasis

Cruz, Criselda Jean G.; Yang, Chao‐Chun

doi:10.3389/fmolb.2023.1196323

Cited by 3 publications

(2 citation statements)

References 81 publications

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“…Of note, IL-23 has a main role for Th17-and Th22-mediated cytokine formation, in other words, Th17 discharges IL-17, IL-22, and TNF-α, and in contrast Th22 forms IL-22. In general, such inflammatory signals have been demonstrated to be accompanied by the dermal and systemic manifestations in PV, such as keratinocyte proliferations, dermal infiltration by immune cells, vasodilation, and angiogenesis (formation of new blood vessels) [7] .…”

Section: Discussionmentioning

confidence: 99%

Serum Interlukin-22 in Psoriasis Vulgaris

2023

The Egyptian Journal of Hospital Medicine

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Background: Psoriasis vulgaris (PV) has been considered as a frequent immune-mediated chronic, inflammatory dermal disease representing approximately 2% globally. Interleukin-22 (IL-22) is a recently described IL-10 family cytokine produced by a lot of cellular sources, which include Th17 and Th22 cells, and it plays an essential role in several autoimmune diseases (AIDs) such as rheumatoid arthritis (RA), and PV. Objective: To determine the diagnostic value of serum IL-22 level for PV; and to examine the possible correlation between serum IL-22 and disease severity and activity. Patients and Methods: This was a case control study conducted on 60 patients complaining from psoriasis; 30 patients complaining from active psoriasis, 30 patients with stable psoriasis, and 30 age-and sex-matched healthy controls (HC). Psoriasis area and severity index was used to assess both involved body area and clinical appearance of psoriatic lesions. Results: IL-22 was significantly increased among cases with active than stable disease and among progressive disease than intermittent disease. There was a statistically significant higher IL-22 among patients compared to HC. Area under curve (AUC) of IL-22 in differentiating patients from HC was excellent with sensitivity of 93.3%, specificity of 83.3% and accuracy of 90%. Conclusion: Interlukin-22 (IL-22) produces inflammatory signals which induce dermal and systemic manifestations in PV. IL-22 serum concentration may be an accurate marker of detecting severity of disease progression.

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Section: Discussionmentioning

confidence: 99%

Serum Interlukin-22 in Psoriasis Vulgaris

2023

The Egyptian Journal of Hospital Medicine

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“…Psoriasis is characterized predominantly by the Th1 type of cytokine profile in skin lesions with elevated levels of INF-γ, TNF-α, IL-12, and IL-18. These cytokines are responsible for the sudden increase in the number of keratinocytes and the absence of maturation, as well as for the characteristic vascular changes of the disease ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Psoriasis Area and Severity Index (PASI) Objectivisation by Flow Cytometry Analysis of Major Lymphocytes Subsets

Pasic,

Dzananovic,

Gojak

et al. 2023

Acta Inform Med

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Background: Psoriasis as an immune-mediated inflammatory skin disease. The basis of the pathogenesis of psoriasis is the dysregulation of immune cell function in genetically predisposed individuals. The characteristic dysfunction of the immune system in patients with psoriasis is manifested as a variation in the cellular phenotypic profile in accordance with the disease status. Objective: The aim of this study was to evaluate the immunophenotypic profile of lymphocytes obtained by flow cytometry as an auxiliary diagnostic tool in the objectivization of the PASI score. Methods: The study group included 40 patients with psoriasis, hospitalized and treated at Dermatology Clinic of Clinical center University of Sarajevo and 30 healthy individuals as controls. After venepunction, the blood samples for determining the immune profile were prepared following standard laboratory procedures using conjugated monoclonal antibodies and BD FACSCanto II flow cytometer. T-lymphocytes (CD3, CD4, CD8), B lymphocytes (CD19), Natural killer cells (NK), and activatet T-cells (CD3HLA) were determined for all patients. Based on the PASI score, the severity and area of the disease was assessed for all psoriasis patients by dermatology specialist. Results: Our data shows no significant difference in any of the lymphocyte subpopulations between psoriasis patients and healthy controls, except CD3HLA. CD3HLA has higher values in patients with psoriasis, p=0.015. Of all the parameters, only NK cells were significantly correlated to the PASI score (rho -0.279; p=0.048). ROC curve analysis revealed a statistically significant difference for the proportion of CD3 lymphocytes (AUC 0.799; p=0.004), CD8 lymphocytes (AUC 0.733; p= 0.023), NK cells (AUC 0.722; p=0.008) and CD3HLA activated T lymphocytes (AUC 0.347; p=0.034). Conclusion: Profile of major lymphocyte subsets in patients with psoriasis is similar to that of healthy controls. The values of CD3, CD8, NK, CD3HLA were defined as biomarkers capable of distinguishing psoriasis according to the severity of the disease. Immunophenotyping of peripheral blood lymphocytes can play an important role as an auxiliary diagnostic method in differentiating the clinical stages of psoriasis and objectifying the PASI score.

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Serum levels of tumour necrosis factor (TNF-α) and interleukin-17 (IL-17) in patients with nail psoriasis: A cross-sectional study

Bhoi,

Grover,

Singal

et al. 2024

IJDVL

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Background Psoriasis is a common chronic inflammatory disorder affecting all aspects of a patient’s life. Nail involvement is frequent, but little is known about its associated inflammatory biomarker profile, including similarities or differences from cutaneous disease. Aims We conducted this cross-sectional study to evaluate serum levels of inflammatory cytokines [tumour necrosis factor-alpha (TNF-α) and interleukin -17 (IL-17)] in patients with nail psoriasis and compared these to psoriasis patients without nail involvement, as well as in non-psoriatic healthy controls. Methods Adult psoriasis patients with (Group I, n = 30) and without nail involvement (Group-II, n = 30) were sequentially recruited. In addition, non-psoriatic healthy controls (Group-III, n = 20) were recruited. The nail disease severity by NAPSI score was determined for patients in Group I. Cutaneous disease severity (by PASI score) and presence of psoriatic arthritis (through CASPAR criteria) were evaluated for patients in Groups I and II. Serum levels of TNF-α, IL-17, erythrocyte sedimentation rate (ESR), rheumatoid factor (RA factor), and anti-cyclic citrullinated peptide antibody (Anti-CCP) were evaluated for all three groups. Results The median age was significantly higher for Group I as compared to Group II patients (41 ± 12.6 years vs 30 ± 12.4 years, p = 0.017). Group I patients also had higher median PASI score than Group II patients, although the difference was not statistically significant (10 ± 11.41 vs 6.50 ± 5.46, p = 0.275). The mean serum IL-17 levels were significantly higher for Group-I (113.39 ± 251.30 pg/mL) than Group II (27.91 ± 18.22 pg/mL, p = 0.002) and Group III (25.67 ± 12.08 pg/mL, p = 0.005). A weak positive correlation was found between NAPSI and serum IL-17 levels (Spearman’s Rho = 0.355) though not statistically significant (p = 0.054). Correlation between serum IL-17 and PASI was poor for Group-I patients (Spearman’s Rho = 0.13, p = 0.944) and strongly negative for Group-II patients (Spearman’s Rho = −0.368, statistically significant with p = 0.045). The mean serum levels of TNF-α were below the detection threshold of the assay kit, hence no meaningful comparison could be made. Limitations A small sample size and low sensitivity of TNF-α assay kit. Conclusion Our study showed that nail psoriasis could be independently associated with an elevation of IL-17. This can help choose appropriate drugs and estimate drug response in patients with nail psoriasis.

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Clinical application of serum biomarkers for detecting and monitoring of chronic plaque psoriasis

Cited by 3 publications

References 81 publications

Serum Interlukin-22 in Psoriasis Vulgaris

Serum Interlukin-22 in Psoriasis Vulgaris

Psoriasis Area and Severity Index (PASI) Objectivisation by Flow Cytometry Analysis of Major Lymphocytes Subsets

Serum levels of tumour necrosis factor (TNF-α) and interleukin-17 (IL-17) in patients with nail psoriasis: A cross-sectional study

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