Clinical application of prostaglandin E1 (PGE1) upon orthodontic tooth movement

Yamasaki, Kenichi; Shibata, Y.; Imai, Shoichi; Tani, Yuji; Shibasaki, Yoshinobu; Fukuhara, Tatsuo

doi:10.1016/0002-9416(84)90091-5

Cited by 225 publications

(124 citation statements)

References 20 publications

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“…They found a significant increase in the rate of tooth movement and number of osteoclasts present after local administration of osteocalcin in rats compared to controls that only received administration of phosphate-buffered saline (PBS). Yamasaki et al 48,49 similarly showed an increase in the rate of tooth movement after local administration of prostaglandin E1, a biochemical mediator of bone resorption in both monkeys and humans.…”

Section: Effect Of Bone Remodeling Rates and Density On Tooth Movementmentioning

confidence: 98%

Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement

Owen¹,

Campbell

Feng

et al. 2017

American Journal of Orthodontics and Dentofacial Orthopedics

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Section: Effect Of Bone Remodeling Rates and Density On Tooth Movementmentioning

confidence: 98%

Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement

Owen¹,

Campbell

Feng

et al. 2017

American Journal of Orthodontics and Dentofacial Orthopedics

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“…OPG gene transfer to the PDL was shown to inhibit tooth movement and osteoclast differentiation (Kanzaki et al, 2006;Kanzaki et al, 2004;. Although PGE1 seems to increase the rate of tooth movement and root resorption (Lee, 1990;Spielmann, Wieslander & Hefti, 1989;Yamasaki, Shibasaki & Fukuhara, 1983;Yamasaki et al, 1984;Zhang, 1992), some of the PGE2 effects in orthodontics are still controversial. In bone biology, lower dosages of PGE2 were shown to have anabolic effects, whereas higher dosages appear to disrupt this effect and cause bone resorptionthis effect appears to be linked to a consequential increase in IGF-1 levels (Baylink, Finkelman & Mohan, 1993).…”

Section: Biological Factors In Rate Of Tooth Movement and Errmentioning

confidence: 99%

Orthodontic mechanotransduction and the role of the P2X7 receptor

Viecilli

Katona

Chen

et al. 2009

American Journal of Orthodontics and Dentofacial Orthopedics

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DEDICATIONTo my parents, who have supported my education. iv ACKNOWLEDGMENTSOne of the most important things I have learned during my PhD is the necessity of the existence of a working network of people that can help you achieve your goals. The more effectively this network functions, the higher the chance you will achieve the goals quickly.I would first like to thank my parents, who have unconditionally supported my decision to abandon a profitable private practice in Orthodontics, and return to humble student conditions while aiming for a full time academic career.I also thank my girlfriend Laura Kruter who has (almost always) been ok with my, some might say, not very sane ideas. Sometimes they do turn out fine, though (like this "PhD" one).I can hardly think of anyone else that could have complemented my work and ideas during this Program as well as Dr. Thomas Katona. While I was passionately conditioned to an idea, he was always rational and careful. While I was sometimes furious with a shortcoming, he was always temperate and humorous. When I ran into his office with some news about a project, he would always listen and almost never seem too busy to see me. While I was working and something went wrong, he would listen and wonder with me about the "whys" and "hows", instead of telling me what to do or express disappointment. He was even subject to some of my home culinary experiments. I was extremely fortunate to find someone that thought about science the same way I did, and that actually helped me with my project instead of just telling me what to do. I felt like we worked as a team, and that helped to increase my motivation during my studies. The third part of this project tested the role of the P2X7 receptor in the dentoalveolar morphology of C57B/6 mice. P2X7R KO (knockout) mice were compared to C57B/6 WT to identify differences in a maxillary molar and bone. Tooth dimensions viii were measured and 3D bone morphometry was conducted. No statistically significant differences were found between the two mouse types. P2X7R does not have a major effect on alveolar bone or tooth morphology.The final part examines the role of the P2X7 receptor in a controlled biomechanical model. Orthodontic mechanotransduction was compared in wild-type (WT) and P2X7R knock-out (KO) mice. Using Finite Element Analysis, mouse mechanics were scaled to produce typical human stress levels. Relationships between the biological responses and the calculated stresses were statistically tested and compared.There were direct relationships between certain stress magnitudes and root resorption and bone formation. Hyalinization and root and bone resorption were different in WT and KO. Orthodontic responses are related to the principal stress patterns in the PDL and the P2X7 receptor plays a significant role in their mechanotransduction.

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“…Without management of the biological responses that occur after a force is applied to a tooth, it would be very difficult to observe a faster velocity of tooth movement in the future. [35][36][37][38][39] Based on the results of this study, in a given population, no significant difference in the rate of tooth movement is likely to be found between groups with different bracket types. On the other hand, it is not possible to predict accurately the time required for tooth retraction in individual patients due to the great amount of variability observed.…”

Section: Discussionmentioning

confidence: 71%

Canine retraction and anchorage loss: Self-ligating versus conventional brackets in a randomized split-mouth study

Monini

Júnior

Martins

et al. 2014

The Angle Orthodontist

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Objective: To evaluate the velocity of canine retraction, anchorage loss and changes on canine and first molar inclinations using self-ligating and conventional brackets. Materials and Methods: Twenty-five adults with Class I malocclusion and a treatment plan involving extractions of four first premolars were selected for this randomized split-mouth control trial. Patients had either conventional or self-ligating brackets bonded to maxillary canines randomly. Retraction was accomplished using 100-g nickel-titanium closed coil springs, which were reactivated every 4 weeks. Oblique radiographs were taken before and after canine retraction was completed, and the cephalograms were superimposed on stable structures of the maxilla. Cephalometric points were digitized twice by a blinded operator for error control, and the following landmarks were collected: canine cusp and apex horizontal changes, molar cusp and apex horizontal changes, and angulation changes in canines and molars. The blinded data, which were normally distributed, were analyzed through paired t-tests for group differences. Results: No differences were found between the two groups for all variables tested. Conclusions: Both brackets showed the same velocity of canine retraction and loss of anteroposterior anchorage of the molars. No changes were found between brackets regarding the inclination of canines and first molars. (Angle Orthod. 2014;84:846-852.)

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Clinical application of prostaglandin E1 (PGE1) upon orthodontic tooth movement

Cited by 225 publications

References 20 publications

Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement

Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement

Orthodontic mechanotransduction and the role of the P2X7 receptor

Canine retraction and anchorage loss: Self-ligating versus conventional brackets in a randomized split-mouth study

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