Clinical application of porcine small intestinal submucosa in the management of infected or potentially contaminated abdominal defects

Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds

“…23 In clinical applications, noncrosslinked ECM scaffolds are the only grafts that are indicated for contaminated wounds because of the antibacterial effects associated with their degradation. 53 Taken together, the beneficial biologic effects of ECM scaffold degradation and the loss of scaffold mechanical strength associated with scaffold degradation would suggest that a balance of these seemingly mutually exclusive events is necessary to realize functional tissue reconstruction.…”

Minimally Invasive Surgical Technique in the Management of Perianal Fistulas Using the Surgisis® AFP Material

“…This has important implications for the entire treatment process, since reoperations are characterized by reduced efficiency (65). Preliminary medical data describing the resistance of the SIS (small intestine submucosa) material to infection with the possibility of active inflammation contamination (66,67,68) were not confirmed by studies concerning the treatment of anal fistulas. Therefore, proper eradication and perianal abscess drainage are recommended, prior to AFP plug implantations (55, 65,69).…”

Skeletal Muscle Tissue Engineering Using Biological Scaffolds for Repair of Abdominal Wall Defects in a Rabbit Model

“…Recently, new biodegradable biomaterials developed from biological materials mainly of collagen in nature have been tested for repair of body wall instead of the non-biodegradable synthetic materials. Bovine pericardium, human cadaveric fascia lata, human dura mater and collagen-based materials derived from porcine small intestine submucosa have been investigated for reconstruction of abdominal wall defects (Ueno et al, 2004;Saaverda et al, 2001;Santillan et al 1995;Rodgers et al, 1981). However in most research, it is indicated that these collagen based biomaterials are failed to be replaced by skeletal muscle tissue or regeneration of muscle tissue is not observed as whole therefore optimal muscle recovery or regeneration may require the use of novel technology like tissue engineering.…”