Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery

Dho, Yun Sik; Lee, Doohee; Ha, Teahyun; Ji, So Young; Kim, Kyung Min; Kang, Hee Yoon; Kim, Min Sung; Kim, Jin Wook; Cho, Won Sang; Kim, Yong Hwy; Kim, Young Gyu; Park, Sang Joon; Park, Shin Young

doi:10.1038/s41598-021-86546-y

Cited by 30 publications

(29 citation statements)

References 31 publications

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“…The DICOM files were imported to MEDIP software for 3D-rendering, trimming the background, and smoothing processing. The MEDIP software is easy to operate due to its machine learning-based semi-automated segmentation function 30 . Thus, the 3D data can be prepared by medical staff without computer expertise.…”

Section: Methodsmentioning

confidence: 99%

“…The inside-out AR navigation (METAMEDIP navigation) was developed using ARkit® (Apple Inc.). It has not been released yet, but the technical methods were described in the previous study 30 . The inside-out AR navigation was processed in three steps: 1) device recognition is visualized, followed by 2) QR marker recognition, and 3) AR implementation and registration within the running environment.…”

Section: Methodsmentioning

confidence: 99%

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Navigation of frameless fixation for gamma knife radiosurgery using fixed augmented reality

Moon

Park²,

Kim³

et al. 2022

Sci Rep

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Augmented reality (AR) offers a new medical treatment approach. We aimed to evaluate frameless (mask) fixation navigation using a 3D-printed patient model with fixed-AR technology for gamma knife radiosurgery (GKRS). Fixed-AR navigation was developed using the inside-out method with visual inertial odometry algorithms, and the flexible Quick Response marker was created for object-feature recognition. Virtual 3D-patient models for AR-rendering were created via 3D-scanning utilizing TrueDepth and cone-beam computed tomography (CBCT) to generate a new GammaKnife Icon™ model. A 3D-printed patient model included fiducial markers, and virtual 3D-patient models were used to validate registration accuracy. Registration accuracy between initial frameless fixation and re-fixation navigated fixed-AR was validated through visualization and quantitative method. The quantitative method was validated through set-up errors, fiducial marker coordinates, and high-definition motion management (HDMM) values. A 3D-printed model and virtual models were correctly overlapped under frameless fixation. Virtual models from both 3D-scanning and CBCT were enough to tolerate the navigated frameless re-fixation. Although the CBCT virtual model consistently delivered more accurate results, 3D-scanning was sufficient. Frameless re-fixation accuracy navigated in virtual models had mean set-up errors within 1 mm and 1.5° in all axes. Mean fiducial marker differences from coordinates in virtual models were within 2.5 mm in all axes, and mean 3D errors were within 3 mm. Mean HDMM difference values in virtual models were within 1.5 mm of initial HDMM values. The variability from navigation fixed-AR is enough to consider repositioning frameless fixation without CBCT scanning for treating patients fractionated with large multiple metastases lesions (> 3 cm) who have difficulty enduring long beam-on time. This system could be applied to novel GKRS navigation for frameless fixation with reduced preparation time.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Navigation of frameless fixation for gamma knife radiosurgery using fixed augmented reality

Moon

Park²,

Kim³

et al. 2022

Sci Rep

Self Cite

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“…Therefore, 3D printing‐related medical devices have been rapidly applied in many medical fields. The surgical simulation system for anatomical disease models is one of the most promising areas for the clinical application of 3D printing technology 8,9 . The patient‐specific disease model which is manufactured using 3D printing technology can ensure the precise definition of the disease scope and the detailed reflection of the relevant anatomical structure 10–13 .…”

Section: Introductionmentioning

confidence: 99%

Mechanical and medical imaging properties of 3D‐printed materials as tissue equivalent materials

Gao²,

et al. 2021

J Applied Clin Med Phys

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Three materials of polylactic acid (PLA), polyamide 12 (PA12), and light curing resin (LCR) were used to construct phantom using 3D printing technology. The mechanical and medical imaging properties of the three materials, such as elastic modulus, density, effective atomic number, X‐ray attenuation coefficient, computed tomography (CT) number, and acoustic properties, were investigated. The results showed that the elastic modulus for PLA was 1.98 × 103 MPa, for PA12 was 848 MPa, for LCR was 1.18×103 MPa, and that of three materials was close to some bones. In the range of 40∼120 kV, the X‐ray attenuation coefficient of three materials decreased with increasing tube voltage. The CT number for PLA, PA12, and LCR was 144, −88, and 312 Hounsfield units at 120 kV tube voltage, respectively. The density and the effective atomic number product (ρ*Zeff) were computed from three materials and decreased in the order of LCR, PLA, and PA12. The acoustic properties of materials were also studied. The speeds of sound of three materials were similar with those of some soft tissues.

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“…Obtained based on medical imaging data, virtual and real three-dimensional (3D) models find their application according to the literature analysis in such specialties as maxillofacial surgery and dentistry (58.3%) [ 6 , 7 , 8 , 9 ] and orthopaedics (23.7%) [ 10 , 11 , 12 , 13 ]. Other areas include neurosurgery [ 14 ], oncology [ 15 ], plastic surgery [ 16 ], cardiology [ 17 ], laryngology [ 18 ], dermatology [ 19 ], and pulmonology [ 20 ]. In the areas mentioned earlier, both anatomical models for planning procedures and surgical templates are usually used to increase precision and shorten the operation time [ 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Procedure Increasing the Accuracy of Modelling and the Manufacturing of Surgical Templates with the Use of 3D Printing Techniques, Applied in Planning the Procedures of Reconstruction of the Mandible

Turek

Pakla²,

Budzik

et al. 2021

JCM

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The application of anatomical models and surgical templates in maxillofacial surgery allows, among other benefits, the increase of precision and the shortening of the operation time. Insufficiently precise anastomosis of the broken parts of the mandible may adversely affect the functioning of this organ. Applying the modern mechanical engineering methods, including computer-aided design methods (CAD), reverse engineering (RE), and rapid prototyping (RP), a procedure used to shorten the data processing time and increase the accuracy of modelling anatomical structures and the surgical templates with the use of 3D printing techniques was developed. The basis for developing and testing this procedure was the medical imaging data DICOM of patients treated at the Maxillofacial Surgery Clinic of the Fryderyk Chopin Provincial Clinical Hospital in Rzeszów. The patients were operated on because of malignant tumours of the floor of the oral cavity and the necrosis of the mandibular corpus, requiring an extensive resection of the soft tissues and resection of the mandible. Familiarity with and the implementation of the developed procedure allowed doctors to plan the operation precisely and prepare the surgical templates and tools in terms of the expected accuracy of the procedures. The models obtained based on this procedure shortened the operation time and increased the accuracy of performance, which accelerated the patient’s rehabilitation in the further course of events.

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Clinical application of patient-specific 3D printing brain tumor model production system for neurosurgery

Cited by 30 publications

References 31 publications

Navigation of frameless fixation for gamma knife radiosurgery using fixed augmented reality

Navigation of frameless fixation for gamma knife radiosurgery using fixed augmented reality

Mechanical and medical imaging properties of 3D‐printed materials as tissue equivalent materials

Procedure Increasing the Accuracy of Modelling and the Manufacturing of Surgical Templates with the Use of 3D Printing Techniques, Applied in Planning the Procedures of Reconstruction of the Mandible

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