Clinical application of multi-contrast 7-T MR imaging in multiple sclerosis: increased lesion detection compared to 3 T confined to grey matter

Graaf, Wolter L. de; Kilsdonk, Iris D.; Lopez-Soriano, Alexandra; Zwanenburg, Jaco J.M.; Visser, Fredy; Polman, Chris H.; Castelijns, Jonas A.; Geurts, Jeroen J. G.; Pouwels, Petra J. W.; Luijten, Peter R.; Barkhof, Frederik; Wattjes, Mike P.

doi:10.1007/s00330-012-2619-7

Cited by 65 publications

(59 citation statements)

References 39 publications

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“…For T1 and FLAIR, this was even 91% and 238%, respectively. 26 Another study found a 65% increase in cortical lesion detection with 7T T2*WI versus 3T DIR. 10 The same research group also investigated how various lesion types contributed to physical and cognitive performance.…”

Section: Discussionmentioning

confidence: 97%

Ultra-High-Field MRI Visualization of Cortical Multiple Sclerosis Lesions with T2 and T2*: A Postmortem MRI and Histopathology Study

Jonkman

Klaver

Fleysher³

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: At 7T MR imaging, T2*-weighted gradient echo has been shown to provide high-resolution anatomic images of gray matter lesions. However, few studies have verified T2*WI lesions histopathologically or compared them with more standard techniques at ultra-high-field strength. This study aimed to determine the sensitivity of T2WI and T2*WI sequences for detecting cortical GM lesions in MS.

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Section: Discussionmentioning

confidence: 97%

Ultra-High-Field MRI Visualization of Cortical Multiple Sclerosis Lesions with T2 and T2*: A Postmortem MRI and Histopathology Study

Jonkman

Klaver

Fleysher³

et al. 2015

AJNR Am J Neuroradiol

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“…However, these techniques have low sensitivity for the heterogeneous pathologic substrate of individual lesions. Although a recent study [107] compared T 1 WI, T 2 WI and FLAIR at both 3T and 7T, these techniques did not appear to increase sensitivity for detection of WM lesions. On the other hand, 3D--FLAIR at 7T could be tailored to improve sensitivity in depicting grey matter lesions [107].…”

Section: Inversion Recoverymentioning

confidence: 89%

Current Developments In Mri For Assessing Rodent Models of Multiple Sclerosis

et al. 2014

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MRI is a key radiological imaging technique that plays an important role in the diagnosis and characterization of heterogeneous multiple sclerosis (MS) lesions. Various MRI methodologies such as conventional T 1/T 2 contrast, contrast agent enhancement, diffusion-weighted imaging, magnetization transfer imaging and susceptibility weighted imaging have been developed to determine the severity of MS pathology, including demyelination/remyelination and brain connectivity impairment from axonal loss. The broad spectrum of MS pathology manifests in diverse patient MRI presentations and affects the accuracy of patient diagnosis. To study specific pathological aspects of the disease, rodent models such as experimental autoimmune encephalomyelitis, virus-induced and toxin-induced demyelination have been developed. This review aims to present key developments in MRI methodology for better characterization of rodent models of MS.

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“…Additional pulse sequences such as the double inversions recovery (DIR) and the phase sensitive inversion recovery (PSIR) sequences have improved the detection rate of cortical GM lesions and the sensitivity can be even further increased by applying these pulse sequences at higher magnetic field strengths (Fig. 4) [20,21]. However, it has been shown that the sensitivity of MRI using a dedicated protocol for grey matter detection of disease activity (or its absence) by MRI in a patient that receives an immunomodulatory treatment represents a measure of treatment response.…”

Section: New Mri Markers and Techniques For Ms Diagnosismentioning

confidence: 99%