Abstract:With the development of scientific technology, the transition to the intelligent era of digitalization and automation is an irresistible trend for medical laboratories. Medical diagnosis systems have undergone significant changes as a result of intelligent technologies, such as machine learning, artificial intelligence, and the Internet of Things, from the collection, transmission, and detection of test samples to the review of reports and the provision of clinical feedback. In addition to significantly enhanc… Show more
“…They believed that AI-based novel technologies greatly enhance the efficiency, consistency, and accuracy of laboratory examinations. Conventional laboratory medicine will ultimately enter a new digital and AI-based era [21].…”
Since the new iLABMED was founded in June 2023, it has published three issues with 21 articles (till Dec 2023). As a journal majored in laboratory medicine, iLABMED also has to face many opportunities and challenges of laboratory medicine. This editorial summarized the main opportunities and challenges faced by iLABMED. The future prospects of laboratory medicine, which must be highlighted by iLABMED were also discussed based on a brief review of the current advances in laboratory medicine. iLABMED will continue to provide a useful platform for general‐interested, insightful, and informative articles with high quality.
“…They believed that AI-based novel technologies greatly enhance the efficiency, consistency, and accuracy of laboratory examinations. Conventional laboratory medicine will ultimately enter a new digital and AI-based era [21].…”
Since the new iLABMED was founded in June 2023, it has published three issues with 21 articles (till Dec 2023). As a journal majored in laboratory medicine, iLABMED also has to face many opportunities and challenges of laboratory medicine. This editorial summarized the main opportunities and challenges faced by iLABMED. The future prospects of laboratory medicine, which must be highlighted by iLABMED were also discussed based on a brief review of the current advances in laboratory medicine. iLABMED will continue to provide a useful platform for general‐interested, insightful, and informative articles with high quality.
“…With the advancement of automation technologies, the integration of automated processing equipment into the pre-treatment steps may potentially address the drawbacks of this cRMP. Additionally, considering the absence of recognized RMPs for the determination of serum tumor markers, our next endeavor involves the application of LC-MS/MS to develop intelligent, integrated solutions for quantifying serum tumor markers [29,30].…”
BackgroundAccurate quantification of 17‐hydroxyprogesterone (17‐OHP) in serum is vital for clinical and research applications. However, inter‐laboratory variability in test results exists owing to the lack of a standardized reference measurement procedure (RMP). Therefore, in this study, we developed a highly accurate, cost‐effective, and user‐friendly candidate RMP (cRMP) for analyzing 17‐OHP in serum.MethodsWe quantified 17‐OHP in serum using a one‐step liquid–liquid extraction method with the addition of 17‐OHP‐13C3, followed by liquid chromatography–tandem mass spectrometry. The ability of these methods to suppress interference was evaluated by chromatographic analysis. We assessed accuracy, specificity, the lower limit of quantitation, linearity, and matrix effects by following the standards specified by the Clinical and Laboratory Standards Institute. The consistency between the developed cRMP and the chemiluminescence method was evaluated through experiments with 120 clinical samples.ResultsThe developed cRMP required only 8 min for accurate quantification of serum 17‐OHP without bias from matrix effects or interference from 19 metabolites added as potential interferents. The method exhibited favorable measurement performance, with a quantitation limit of 0.086 ng/mL, linear range of 0.1–400 ng/mL, a total imprecision of ≤2.90%, spike recovery of 100.1%–100.6%, and relative deviations from assigned target values (RfB Institution) of −2.91% to 1.10%. The cRMP demonstrated good consistency with the conventional assay (chemiluminescence method), with a correlation coefficient R of 0.96977.ConclusionA cRMP with high accuracy, cost‐effectiveness, and convenient operation was developed for quantifying 17‐OHP in serum. Its simplicity and robust performance make it an invaluable addition to the arsenal of analytical tools available for laboratories. This method can enhance the accuracy and reliability of 17‐OHP measurements across various laboratories.
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