Clinical application of indocyanine green (ICG) fluorescent imaging of hepatoblastoma

Yamamichi, Taku; Oue, Takaharu; Yonekura, Takeo; Owari, Mitsugu; Nakahata, Kengo; Umeda, Satoshi; Nara, Kiyomitsu; Ueno, Takayoshi; Uehara, Shuichiro; Usui, Noriaki

doi:10.1016/j.jpedsurg.2015.01.014

Cited by 71 publications

(66 citation statements)

References 8 publications

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“…It is mainly used in the intraoperative navigation of tumor, and has good water solubility with high safety, but lacks tumor targeting [25]. The conventional NIR dye needs to be labeled with peptides or a specific antigen marker, which facilitates targeting, although only a part of the tumor can be identified, and the chemical combination often affects the stability of the target molecule [26,27].…”

Section: Discussionmentioning

confidence: 99%

The Application of Heptamethine Cyanine Dye DZ-1 and Indocyanine Green for Imaging and Targeting in Xenograft Models of Hepatocellular Carcinoma

Zhang

Zhao

Zhou

et al. 2017

IJMS

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Near infrared fluorescence (NIRF) imaging has strong potential for widespread use in noninvasive tumor imaging. Indocyanine green (ICG) is the only Food and Drug Administration (FDA) -approved NIRF dye for clinical diagnosis; however, it is unstable and poorly targets tumors. DZ-1 is a novel heptamethine cyanine NIRF dye, suitable for imaging and tumor targeting. Here, we compared the fluorescence intensity and metabolism of DZ-1 and ICG. Additionally, we assayed their specificities and abilities to target tumor cells, using cultured hepatocellular carcinoma (HCC) cell lines, a nude mouse subcutaneous xenograft model of liver cancer, and a rabbit orthotopic transplantation model. We found that DZ-1 accumulates in tumor tissue and specifically recognizes HCC in subcutaneous and orthotopic models. The NIRF intensity of DZ-1 was one order of magnitude stronger than that of ICG, and DZ-1 showed excellent intraoperative tumor targeting in the rabbit model. Importantly, ICG accumulated at tumor sites, as well as in the liver and kidney. Furthermore, DZ-1 analog-gemcitabine conjugate (NIRG) exhibited similar tumor-specific targeting and imaging properties, including inhibition of tumor growth, in HCC patient-derived xenograft (PDX) mice. DZ-1 and NIRG demonstrated superior tumor-targeting specificity, compared to ICG. We show that DZ-1 is an effective molecular probe for specific imaging, targeting, and therapy in HCC.

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Section: Discussionmentioning

confidence: 99%

The Application of Heptamethine Cyanine Dye DZ-1 and Indocyanine Green for Imaging and Targeting in Xenograft Models of Hepatocellular Carcinoma

Zhang

Zhao

Zhou

et al. 2017

IJMS

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“…The main parameter was the timing of ICG injection. There is no consensus in the timing of the ICG injection among the literature, which varies from 1 to 7 days prior to the operation . Compared to the studies from Europe, Japanese studies have longer interval between the injection and the surgery, as a higher dose of ICG (0.5 mg/kg) is often used for preoperative liver function evaluation .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that ICG fluorescence could have a role in demonstrating superficial liver lesions . These studies have originated from Japan and Europe, with no North American experience reported so far .…”

Section: Introductionmentioning

confidence: 99%

An initial report on the intraoperative use of indocyanine green fluorescence imaging in the surgical management of liver tumorss

2016

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“…It is contraindicated in those allergic to iodinated contrasts or with thyroid disorders. 9,[11][12][13][14] The use of fluorescence in surgery is emerging, but experience in splenic pathology is very limited. Kawasaki et al 15 used ICG during distal pancreatectomies with splenic preservation.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Partial Splenectomy Assisted by Fluorescence in a 13-Year-Old Girl

Bada-Bosch

Mata

Torre

et al. 2020

European J Pediatr Surg Rep

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Partial splenectomy allows preserving immune function in benign splenic lesions such as epidermoid cysts. Determining the plane of resection and perfusion of the spleen remnant can be difficult, especially in centrally located lesions. We present a 13-year-old girl with a symptomatic splenic cyst of 6 cm in diameter located next to the splenic hilum. Laparoscopic partial splenectomy was performed through a 10-mm umbilical approach and three accessory 5-mm ports. Intraoperative intravenous injection of indocyanine green (ICG) at 0.2 mg/kg guided the careful dissection of the splenic hilum and checked the spleen perfusion once the upper arterial branch was clamped. The subsequent wash-out of the ICG allowed inspection of the peripheral vascular return of the splenic remnant through polar veins. Surgery was uneventful with minimal blood loss. Follow-up ultrasound scan revealed a well-perfused small splenic remnant with no signs of recurrence.Laparoscopic partial splenectomy is feasible in benign splenic tumors, especially in those cases of peripheral location. Fluorescence facilitates the safe dissection of the splenic hilum, the visualization of the transection plane of the spleen and the perfusion of the remnant in cases of anatomically and technically complicated partial splenectomies.

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Clinical application of indocyanine green (ICG) fluorescent imaging of hepatoblastoma

Cited by 71 publications

References 8 publications

The Application of Heptamethine Cyanine Dye DZ-1 and Indocyanine Green for Imaging and Targeting in Xenograft Models of Hepatocellular Carcinoma

The Application of Heptamethine Cyanine Dye DZ-1 and Indocyanine Green for Imaging and Targeting in Xenograft Models of Hepatocellular Carcinoma

An initial report on the intraoperative use of indocyanine green fluorescence imaging in the surgical management of liver tumorss

Laparoscopic Partial Splenectomy Assisted by Fluorescence in a 13-Year-Old Girl

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