2008
DOI: 10.1177/000348940811700908
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Clinical Application of in Situ Tissue Engineering Using a Scaffolding Technique for Reconstruction of the Larynx and Trachea

Abstract: Our current technique of in situ tissue engineering using a scaffold shows great potential for use in the regeneration of airway defects.

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Cited by 142 publications
(93 citation statements)
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“…To this end, allografts and a wide range of biomaterials have been used for replacing tracheal defects. 9,86,87 The general problems associated with these kinds of implants are restenosis, collapse of the airway due to mechanical instability, and the problems associated with the lack of functional epithelium, which leads to infections and also facilitates restenosis. 88 When the implant is not strong enough, airway collapse is the major issue.…”
Section: Epithelium In Clinical Full Organ/multicellular Tissue-enginmentioning
confidence: 99%
“…To this end, allografts and a wide range of biomaterials have been used for replacing tracheal defects. 9,86,87 The general problems associated with these kinds of implants are restenosis, collapse of the airway due to mechanical instability, and the problems associated with the lack of functional epithelium, which leads to infections and also facilitates restenosis. 88 When the implant is not strong enough, airway collapse is the major issue.…”
Section: Epithelium In Clinical Full Organ/multicellular Tissue-enginmentioning
confidence: 99%
“…These induced pluripotent stem (iPS) cells present an important advantage over "real" embryonic stem cells, in that they do not require an embryo to be sacrificed, and that they ultimately will allow autologous transplantation of stem cells to repair damaged tissues (Park et al, 2008). The reprogramming process requires retroviral transduction with at least three genes: Oct3/4, Sox2 and Klf4 (Geoghegan and Byrnes, 2008;Hong et al, 2009), and may require suppression of the tumor suppressor genes p53 and p21 (Hong et al, 2009).…”
Section: Gm Roomansmentioning
confidence: 99%
“…Such a condition is, as stated above, a prime example where repair of the airway by stem cells could be used. Omori et al (2008) developed a tissue scaffold made from a mesh tube covered by collagen sponge, which was implanted to repair the larynx and trachea in 4 patients (1 with subglottic stenosis and 3 with thyroid cancer), where the cartilage of the cervical trachea and laryngeal cartilages were resected and reconstructed by use of the scaffold. This was reported to result in a well-epithelialized airway lumen without any obstruction.…”
Section: Gm Roomansmentioning
confidence: 99%
“…94 This technology of employing decellularized organ scaffolds is advantageous as the native three-dimensional (3D) tissue architecture, vascular tree, and ECM-related cues, all with high developmental significance, seem to be well preserved 94,96 in the organ scaffold. A variety of complex modular organs have now been bioengineered, some of which, such as the larynx 97,98 and vagina, 99 have found clinical use. We highly recommend reviews 87,98 including those by Orlando et al…”
Section: The State Of the Artmentioning
confidence: 99%