Clinical Application of Human Adipose Tissue–Derived Mesenchymal Stem Cells in Progressive Hemifacial Atrophy (Parry-Romberg Disease) With Microfat Grafting Techniques Using 3-Dimensional Computed Tomography and 3-Dimensional Camera

Koh, Kyung; Oh, Tae Suk; Kim, Hoon; Chung, In Wook; Lee, Kang Woo; Lee, Hyo Bo; Park, Eun Jung; Jung, Jae Seob; Shin, Il Seob; Chan, Jeong; Choi, Jong Woo

doi:10.1097/sap.0b013e31826239f0

Cited by 136 publications

(93 citation statements)

References 17 publications

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“…En segundo lugar citamos otro ensayo clínico aleatorizado publicado por Kyung Suk Koh (14) en Corea del Sur. Este autor toma 10 pacientes con diagnóstico de enfermedad de Parry-Romberg y los asigna de manera aleatorio a 2 grupos, cada uno con 5 pacientes.…”

Section: Resultsunclassified

“…Finalmente, el recientemente publicado ensayo aleatorizado de Kyung Suk Koh (14), con nivel de evidencia 2B, incluye 10 pacientes a los que distribuye en 2 grupos, cada uno de 5 pacientes, para recibir lipoinjerto enriquecido o convencional y sigue durante 18 meses. Introduce además de las variables subjetivas de satisfacción del paciente tenidas en cuenta por Sterodimas, mediciones objetivas del comportamiento del lipoinjerto en el tiempo con respecto al porcentaje de reabsorción evaluado mediante TAC tridimensional y cámara fotográfica que realiza también reconstrucción tridimensional.…”

Section: Discussionunclassified

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Revisión sistemática: células madre derivadas del tejido adiposo, utilidad en lipoatrofia facial

Cruz-Sánchez

Gómez-Díaz

2014

Cir. plást. iberolatinoam.

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ResumenEl objetivo de la presente revisión sistemática es determinar si los lipoinjertos enriquecidos con células madre derivadas del tejido adiposo son superiores a los injertos de tejido graso convencionales en el tratamiento de la lipoatrofia facial.Realizamos una búsqueda sistemática de publicaciones en las bases de datos: MEDLINE, SCOPUS, OVID SP, SCIELO y EMBASE y posteriormente, una valoración basada en criterios actuales de medicina basada en la evidencia de las publicaciones encontradas por dos revisores independientes; las discrepancias en el análisis se resolvieron por acuerdo. Los criterios de inclusión fueron: ensayos clínicos aleatorizados, series clínicas y reportes de casos en humanos, excluyendo los ensayos en animales.Encontramos 6 publicaciones que cumplían con los criterios previamente mencionados. Entre éstas se incluyeron 2 ensayos clínicos aleatorizados controlados que recogían la superioridad de los lipoinjertos enriquecidos con células madre derivadas del tejido adiposo en el tratamiento de la lipoatrofia facial en términos de resistencia a la reabsorción (preservación del volumen) y menor necesidad de nuevos lipoinjertos, en comparación con los lipoinjertos convencionales.Concluimos diciendo que existen publicaciones con buenos niveles de evidencia que sugieren que los lipoinjertos enriquecidos con células madre derivadas del tejido adiposo son superiores a los lipoinjertos convencionales en el tratamiento de la lipoatrofia facial. No obstante, son estudios de reciente publicación y aún es necesario tener seguimientos a más largo plazo y con mayor número de pacientes para mejorar los ya buenos niveles de evidencia disponibles.Palabras clave Atrofia facial, Lipoatrofia facial, Hemiatrofia facial, Lipoinjertos, Células madre, Lipoinjertos enriquecidos, Evidencia científica. Nivel de evidencia científica II AbstractThe objective of this systematic review is to determine if the lipografts enriched with stem cells derived from adipose tissue are superior to the conventional fatty tissue grafts in the treatment of facial lipoatrophy.A systematic search was performed for publications in the databases: MEDLINE, SCOPUS, OVID SP, SCIELO and EMBASE. An evaluation was subsequently conducted based on current criteria of evidence-based medicine of the publications found by two independent reviewers and discrepancies in the analysis were resolved by agreement. The inclusion criteria were: randomized clinical trials, clinical series and case reports in humans; the reports in animals were excluded.We found 6 publications that meet the criteria previously mentioned. Between these, 2 randomized controlled clinical trials reported the superiority of the lipografts enriched with stem cells derived from adipose tissue in the treatment of facial lipoatrophy in terms of resistance to the reabsorption (volume preservation) and less need for new lipografts when compared with the conventional lipografts.We conclude that there are publications with good levels of evidence to suggest that the lipografts enriched wi...

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Section: Resultsunclassified

Section: Discussionunclassified

Revisión sistemática: células madre derivadas del tejido adiposo, utilidad en lipoatrofia facial

Cruz-Sánchez

Gómez-Díaz

2014

Cir. plást. iberolatinoam.

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“…Through non-clinical and clinical studies on Buerger's disease, Perry-Romberg disease [1], and critical limb ischemia [2], the authors have already confirmed the revascularization of adipose stem cells and the possibility of treatment via anti-inflammatory reactions. We have also presented clinical results for degenerative arthritis [3].…”

Section: Introductionmentioning

confidence: 97%

“…In particular, it has to be considered seriously that concerns about the possibility of cancer development derived from cultured autologous adipose stem cells. The reasons for concerns about the possibility of cancer promotion by the administration of cultured adipose stem cells [8,9] are as follows: (1) genetic mutations may occur during the culturing process and (2) the growth factors secreted by stem cells may promote the growth of cancer cells and create a favorable environment for them. However, several reports have presented that stem cells inhibit cancer development [10][11][12], which suggests the importance of discerning the characteristics of cultured stem cells.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Multiple Intravenous Administration of Cultured Human Autologous Adipose-Derived Stem Cells on Tumor Biomarker Levels

Chang-hyun¹,

Kim²,

Kim³

2017

J Clin Case Rep

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Many studies have been conducted to cultivate and utilize patients' own adipose-derived stem cells for the treatment of various incurable diseases and for regenerative medicine that can prolong lifespan. Despite the significant achievements made thus far, the lack of confidence with regard to safety, particularly the concern about tumorigenicity, has made researchers hesitant to actively apply cultured human autologous adipose-derived cells in clinical trials. Therefore, studies on the tumorigenicity of cultured adipose-derived stem cells are very important for expanding the field of stem cell-utilizing regenerative medicine. It is also important to study their effect on tumor biomarker levels. Long-term follow-up studies of tumorigenicity after multiple intravenous administrations of cultured human autologous adipose-derived stem cells have not been reported worldwide. Therefore, the authors have examined 462 Koreans who were administered more than 1 billion cultured autologous adipose-derived stem cells multiple times from 2010 to 2013 at medical institutions in Japan. We then conducted the first retrospective research in the world on the changes in eight types of tumor biomarkers over three-six years. According to the results of our analysis, there were no significant changes in the observed tumor biomarkers, irrespective of gender and age. These results suggest that multiple administrations of autologous adipose-derived stem cells cultured in accordance with the authors' method do not affect tumorigenicity.

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“…It characteristically involves the skin and subcutaneous connective tissues and may later progress to affect the underlying musculature, cartilage, and osseous structures with or without development of neurologic symptoms. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]23,26 PRS typically presents initially in children and young adults and slowly progresses over a highly variable course ranging from 2 to 20 years, eventually reaching a "burned-out phase" and stabilizing for no apparent reason. [2][3][4][5][6][8][9][10][14][15][16][17] This peculiar disease course, along with highly variable signs and symptoms, impedes consistent understanding of the underlying pathophysiology of PRS.…”

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confidence: 99%

Parry Romberg Syndrome: 7 Cases and Literature Review

Wong

Phillips

Hagiwara

et al. 2015

American Journal of Neuroradiology

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SUMMARY:Parry Romberg syndrome is a rare progressive hemiatrophy of the face that typically occurs in children and young adults and has a peculiar progression that ceases without apparent cause after a highly variable period. Only a subset of patients with Parry Romberg syndrome will develop secondary neurologic or ophthalmologic symptoms, and prognosis is highly variable. Inconsistency in the pattern of atrophy and the development of associated symptoms in patients with Parry Romberg syndrome has made it challenging to diagnose, prognosticate, and treat. The precise etiology of this disease remains unknown, but some authors have implicated sympathetic cervical ganglion dysfunction, abnormal embryogenesis, autoimmune and inflammatory mechanisms, or vasculopathy as potential causes. We present 7 cases of Parry Romberg syndrome and their associated clinical and imaging findings with specific attention to the radiographic characteristics of this disease. ABBREVIATION: PRS ϭ Parry Romberg syndrome

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Clinical Application of Human Adipose Tissue–Derived Mesenchymal Stem Cells in Progressive Hemifacial Atrophy (Parry-Romberg Disease) With Microfat Grafting Techniques Using 3-Dimensional Computed Tomography and 3-Dimensional Camera

Abstract: Adipose-derived stem cells enhance the survival of fat grafted into the face. A microfat graft with simultaneous ASC injection may be used to treat Parry-Romberg disease without the need for microvascular free flap transfer.

Cited by 136 publications

References 17 publications

Revisión sistemática: células madre derivadas del tejido adiposo, utilidad en lipoatrofia facial

Revisión sistemática: células madre derivadas del tejido adiposo, utilidad en lipoatrofia facial

Effect of the Multiple Intravenous Administration of Cultured Human Autologous Adipose-Derived Stem Cells on Tumor Biomarker Levels

Parry Romberg Syndrome: 7 Cases and Literature Review

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