Clinical Application of Enteral Nutrition Combined with Microbial Preparation for Intestinal Preparation in Elderly Patients with Colorectal Cancer

Shen, Yu; Zhao, Xin; Zhao, Haijian; Chen, Ning; Wang, Jian; Zhuang, Haiwen; Zhang, Xiaoyu

doi:10.12659/msm.935366

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…Three studies examined preoperative use of immunonutrition, including use of oral immunonutrition in advanced pancreatic adenocarcinoma ( 31 ), enteral immunonutrition among patients with colorectal or gastric carcinoma ( 36 ), and immunonutrient-enriched supplementation in patients with colon cancer. Seven studies examined the use of more diverse oral nutrition support across gastrointestinal cancers, including use of preoperative Nutricia ( 35 ), hypercaloric supplementation (Nutridrink Protein) ( 28 ), peripheral intravenous nutrition for patients undergoing workup for biliopancreatic masses ( 29 ), oral nutrition combined with microbial preparations ( 33 ), preoperative oral supplementation for colorectal ( 34 ) and gastrointestinal cancers ( 27 ), and the use of Nutrison Fiber in patients with adenocarcinomas ( 37 ). The final 3 studies examined carbohydrate-rich beverages ( 26 , 32 ) as well as the use of 10% glucose solution before radical gastrectomy ( 25 ).…”

Section: Nutrition Interventions Before Cancer Treatmentmentioning

confidence: 99%

Nutrition as prevention for improved cancer health outcomes: a systematic literature review

Parsons,

Forte,

Abdi

et al. 2023

JNCI Cancer Spectrum

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Background Among adults with cancer, malnutrition is associated with decreased treatment completion, more treatment harms and use of healthcare, and worse short-term survival. To inform the National Institutes of Health Pathways to Prevention (P2P) workshop, Nutrition as Prevention for Improved Cancer Health Outcomes, this systematic review examined the evidence for the effectiveness of providing nutritional interventions before or during cancer therapy to improve outcomes of cancer treatment. Methods We identified randomized controlled trials (RCT) enrolling ≥50 participants published from 2000 through July 2022. We provide a detailed evidence map for included studies and grouped studies by broad intervention and cancer types. We conducted risk of bias and qualitative descriptions of outcomes for intervention and cancer types with a larger volume of literature. Results From 9,798 unique references, 206 RCT from 219 publications met inclusion criteria. Studies primarily focused on non-vitamin/mineral dietary supplements, nutrition support, and route or timing of inpatient nutrition interventions for gastrointestinal or head and neck cancers. Most studies evaluated changes in body weight/composition, adverse events from cancer treatment, length of hospital stay, or quality of life. Few studies were conducted within the U.S. Among intervention and cancer types with a high volume of literature (n = 114), 49% (n = 56) were assessed as high risk of bias. Higher quality studies (low- or medium risk-of-bias) reported mixed results on the effect of nutritional interventions across cancer and treatment-related outcomes. Conclusions Methodological limitations of nutritional intervention studies surrounding cancer treatment impair translation of findings into clinical practice or guidelines.

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Section: Nutrition Interventions Before Cancer Treatmentmentioning

confidence: 99%

Nutrition as prevention for improved cancer health outcomes: a systematic literature review

Parsons,

Forte,

Abdi

et al. 2023

JNCI Cancer Spectrum

View full text Add to dashboard Cite

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Effect of Preoperative Lifestyle Management and Prehabilitation on Postoperative Capability of Colorectal Cancer Patients: A Systematic Review and Meta-Analysis

Zhang,

Hu,

Deng

et al. 2024

Integr Cancer Ther

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Background: The surgical intervention serves as the paramount and prevalent remedy for individuals afflicted with colorectal malignancies, with the significance of perioperative stewardship and convalescence being indisputable. Prehabilitation coupled with preoperative lifestyle modulation has demonstrated efficacy in patients subjected to certain classifications of abdominal procedures. However, the evidence pertaining to its impact on those battling colorectal cancer remains equivocal. Methods: A meta-analysis, grounded in pairwise contrast, of randomized controlled trials (RCTs) was orchestrated, coupled with a systematic review, to probe the efficacy of preoperative lifestyle modulation and prehabilitation on patients’ postoperative functionality and recuperation. An exhaustive exploration of 8 electronic databases and trial registries was undertaken to encompass all pertinent RCTs disseminated in English or Chinese from January 2012 through December 2022. Employing a random-effects model, we evaluated parameters such as the 6-minute walk test (6 MWT), complications, quality of life (QoL), aggregate and postoperative duration of hospitalization (tLHS and postLHS), and healthcare expenditure (HExp) for postoperative patients. Results: A total of 28 RCTs were incorporated into the systematic review and meta-analysis. Relative to conventional preoperative care, rehabilitation or preoperative lifestyle management was found to enhance postoperative 6MWT ( SMD 1.30, 95% CI 0.30 to 2.29) and diminish the complication rate ( OR 0.53, 95% CI 0.40 to 0.69). Nonetheless, no significant discrepancies were observed in QoL ( SMD 1.81, 95% CI −0.26 to 3.87), tLHS ( SMD −0.26, 95% CI −0.68 to 0.15), and postLHS ( SMD −1.46, 95% CI −3.12 to 0.20) between the groups. HExp could not be evaluated due to a lack of sufficient data for synthesis. Most pooled outcomes exhibited significant heterogeneity, urging a cautious interpretation. Subgroup analysis revealed that nutritional interventions could mitigate the incidence of complications, and preoperative exercise could improve tLHS and postLHS. A combined approach of physical, nutritional, and psychological intervention or prehabilitation proved superior to any single intervention in enhancing postoperative capabilities. Conclusion: This meta-analysis delineated the efficacy of preoperative interventions on postoperative capabilities in patients with colorectal cancer, thereby offering evidence for clinical practice. It was concluded that preoperative interventions are unequivocally beneficial for postoperative functional recovery and the reduction of complication rates in patients with colorectal cancer. Nonetheless, the acquisition of more high-level evidence is still necessitated to further ascertain the effectiveness of this strategy for other patient groups and to establish its best practices. The heterogeneity in the pooled outcomes underlines the need for future studies to be more uniform in their design and reporting, which would facilitate more robust and reliable meta-analyses.

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Clinical Application of Enteral Nutrition Combined with Microbial Preparation for Intestinal Preparation in Elderly Patients with Colorectal Cancer

Cited by 2 publications

References 36 publications

Nutrition as prevention for improved cancer health outcomes: a systematic literature review

Nutrition as prevention for improved cancer health outcomes: a systematic literature review

Effect of Preoperative Lifestyle Management and Prehabilitation on Postoperative Capability of Colorectal Cancer Patients: A Systematic Review and Meta-Analysis

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