Clinical Application of Double Ovulation Stimulation in Patients with Diminished Ovarian Reserve and Asynchronous Follicular Development Undergoing Assisted Reproduction Technology

Yang, Yizhuo; Zhang, Ming; Mu, Sha; Guo, Xinmeng; Wang, Hui; Tang, Zhe; Peng, Hongmei

doi:10.1007/s11596-022-2687-0

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…From a literature review, 34 studies were published regarding the double stimulation approach in patients undergoing IVF treatment (Table 1). Among them, 23 studies used GnRH agonist trigger for final oocyte maturation in the first stimulation [3,4,5 ▪ ,7,8,10,11,14–23,24 ▪ ,25–29], six studies used hCG (3 rec-hCG and 2 u-hCG) [30–35], and five studies did not specifically distinguish the type of the trigger (GnRH-a ± hCG or hCG) [13,36–39]. GnRH agonist is the most common agent used for triggering and this tendency might depend on the putative negative effect exerted by the longer half-life of hCG on follicle growth during the subsequent LPS [18].…”

Section: Body Of Evidence Regarding Different Trigger Strategies In M...mentioning

confidence: 99%

GnRH agonist trigger in poor prognosis patients undergoing a multicycle approach through DuoStim or consecutive stimulations: a SWOT analysis

Vaiarelli,

Ruffa,

Cerrillo

et al. 2024

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of review Identify the most recent and significant evidence regarding the ovulation trigger within the framework of a multicycle approach through DuoStim, providing valuable insights for improving treatment strategies in patients with a poor prognosis. Recent findings The trigger method plays a pivotal role in optimizing in-vitro fertilization (IVF) stimulation, influencing oocyte retrieval and maturation rates, as well as follicle recruitment in consecutive ovarian stimulations such as double stimulation. Decision-making involves multiple factors and, while guidelines exist for conventional stimulation, specific recommendations for the multicycle approach are not well established. Summary The different methods for inducing oocyte maturation underscore the need for personalization of IVF protocols. The GnRH agonist trigger induces rapid luteolysis and establishes favorable hormonal conditions that do not adversely affect the recruitment of consecutive follicular waves in the context of DuoStim. It serves as a valid alternative to hCG in freeze-all cycles. This strategy might enhance the safety and flexibility of ovarian stimulations with no impact on oocyte competence and IVF efficacy.

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Section: Body Of Evidence Regarding Different Trigger Strategies In M...mentioning

confidence: 99%

GnRH agonist trigger in poor prognosis patients undergoing a multicycle approach through DuoStim or consecutive stimulations: a SWOT analysis

Vaiarelli,

Ruffa,

Cerrillo

et al. 2024

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

show abstract

Clinical Application of Double Ovulation Stimulation in Patients with Diminished Ovarian Reserve and Asynchronous Follicular Development Undergoing Assisted Reproduction Technology

Cited by 1 publication

References 24 publications

GnRH agonist trigger in poor prognosis patients undergoing a multicycle approach through DuoStim or consecutive stimulations: a SWOT analysis

GnRH agonist trigger in poor prognosis patients undergoing a multicycle approach through DuoStim or consecutive stimulations: a SWOT analysis

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