Clinical application of digital indocyanine green videoangiography in senile macular degeneration

Abstract

Digital indocyanine green videoangiography (ICGV) was done in 34 eyes of 24 patients with aging macular degeneration (AMD), including drusen, either alone (6 eyes) or in association with other AMD changes (9 eyes), geographic atrophy of the retinal pigment epithelium (2 eyes), well-defined choroidal neovascularization (CNV; 3 eyes), occult CNV (12 eyes) and recurrent CNV (11 eyes). Of the 11 eyes with soft drusen, 10 showed abnormal fluorescence in the late ICGV picture. ICGV of the 4 eyes with hard drusen showed no abnormality. The geographic atrophy of the retinal pigment epithelium and choriocapillaris remained hypofluorescent with sharply demarcated boundaries throughout the study. ICGV confirmed the presence of CNV in all 3 eyes with well-defined CNV and in 11 of the 12 eyes with occult CNV. Additionally, all but 1 eye with primary occult CNV and 6 of the 8 eyes with recurrent occult CNV could be reclassified in this study as having well-defined CNV. Overall, ICGV yielded additional information in 17 of the 20 eyes with primary and recurrent occult CNV. Its clinical importance for the evaluation of early stages of AMD has still to be confirmed by future investigations. ICGV is recommended as a diagnostic examination in eyes with CNV poorly defined by fluorescein angiography.

Indocyanine green angiographic findings in central serous chorioretinopathy

“…This might be an explanation for the hyperpermeability findings already reported by other authors [5][6][7][8]. This might be an explanation for the hyperpermeability findings already reported by other authors [5][6][7][8].…”

Topical fundus pulsation measurements in age-related macular degeneration

“…Indocyanine green video angiography is useful for demarcation of neovascular membranes in some eyes, especially when the membrane is poorly defined by fluorescein angiography [3,15,16]. Preliminary results indicate successful laser treatments in these cases [16,17].…”

Age‐dependent variations in the drusen fluorescence on indocyanine green angiography

“…A small series reporting indocyanine green (ICG) angiography of drusen using the scanning laser ophthalmoscope suggested a difference in the appearance of drusen depending on the age of patients 7 . However, there remains conflicting data regarding the behaviour of drusen on ICG angiography 7−9 . Indocyanine green angiography is gaining increased utility in the evaluation of AMD and its neovascular complications.…”

“…7 However, there remains conflicting data regarding the behaviour of drusen on ICG angiography. [7][8][9] Indocyanine green angiography is gaining increased utility in the evaluation of AMD and its neovascular complications. It is relevant and useful to define the ICG fluorescence characteristics of drusen as a baseline to aid in the interpretation of ICG angiography in patients who may also have coexistent exudative disease.…”