Clinical application of breath biomarkers of oxidative stress status

Risby, Terence H.; Sehnert, Shelley S.

doi:10.1016/s0891-5849(99)00212-9

Cited by 161 publications

(98 citation statements)

References 14 publications

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“…Breath analysis is a noninvasive technique and has been used as a tool for screening of many diseases [8][9][10][11]. It is very important to develop breath analysis to early diagnosis of diabetes [12].…”

Section: Introductionmentioning

confidence: 99%

Determination of acetone in human breath by gas chromatography–mass spectrometry and solid-phase microextraction with on-fiber derivatization

Deng

Jie

et al. 2004

Journal of Chromatography B

178

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Section: Introductionmentioning

confidence: 99%

Determination of acetone in human breath by gas chromatography–mass spectrometry and solid-phase microextraction with on-fiber derivatization

Deng

Jie

et al. 2004

Journal of Chromatography B

178

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“…1 NO is excreted in human airways and is detectable in exhaled air in significant amounts ranging from 0.2-1 ppm in the upper respiratory tract and 1-30 ppm at the nasal level. 2,3 NO-targeting diagnostic breath analysis ͑based on NO detection and monitoring͒ remains a challenge, primarily due to the lack of affordable NO detectors of high specificity. The method currently used to measure exhaled NO is chemiluminescence 3 where the NO contained in a sample reacts with an excess of ozone to produce NO 2 with an electron in an excited state ͑NO 2 ‫ء‬ ͒.…”

mentioning

confidence: 99%

A selective nanosensing probe for nitric oxide

Gouma

Kalyanasundaram

2008

Applied Physics Letters

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Measurement of NO gas in exhaled human breath may be used to monitor oxidative stress and pulmonary diseases. Until now, only bulk, expensive, chemiluminescence-based NO monitors have been available to medicine. A nanosensing probe based on WO3 selectively detecting minute nitric oxide gas concentrations in the presence of interfering volatile compounds is presented. This is possible due to the chemical affinity of rhenium trioxide based phases to oxidizing gases. The NO nanoprobe is expected to lead to portable and affordable, noninvasive, single breath sampling, NO diagnostics.

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“…Others tried to eliminate ambient concentrations by having patients or volunteers breathe pure air for a certain time before measurement [67]. This approach is the most effective but cumbersome and time consuming, and will not be applicable for clinical routine purposes.…”

Section: Nitrogen-containing Compoundsmentioning

confidence: 99%

“…But again, because the extent of dilution by dead space gas may be variable and cannot be quantified, the only method to obtain reliable and comparable results is the normalization of samples to alveolar concentration levels, e.g. by the ratio of pCO2 in the sample to end tidal pCO2 when mixed expiratory samples are taken in order to account for the dilution of the sample by dead space air [67][68]. Furthermore, loss of compounds during the sampling procedure must be taken into account.…”

Section: Nitrogen-containing Compoundsmentioning

confidence: 99%

Mass Spectrometric Profiling of Low-Molecular-Weight Volatile Compounds - Diagnostic Potential and Latest Applications

Lechner¹,

Rieder

2007

CMC

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The theoretical use of mass spectrometric profiling of low-molecular-weight volatile compounds, as one possible method to non-invasively and rapidly diagnose a variety of diseases, such as cancer, infection, and metabolic disorders has greatly raised the profile of this technique over the last ten years. Despite a number of promising results, this technique has not been introduced into common clinical practice yet. The use of mass spectrometric profiling of exhaled air is particularly hampered by various technical problems and basic methodological issues which have only been partially overcome. However, breath analysis aside, recently published studies reveal completely new ideas and concepts on how to establish fast and reliable diagnosis by using this valuable tool. These studies focussed on the headspace screening of various bodily fluids and sample fluids obtained during diagnostic procedures, as well as microbial cell cultures and demonstrated the vast diagnostic potential of this technique in a wide variety of settings, predominantly in vitro. It is the aim of the present review to discuss the most commonly detected low-molecular-weight volatile compounds and to summarize the current potential applications, latest developments and future perspectives of this promising diagnostic approach.

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Clinical application of breath biomarkers of oxidative stress status

Cited by 161 publications

References 14 publications

Determination of acetone in human breath by gas chromatography–mass spectrometry and solid-phase microextraction with on-fiber derivatization

Determination of acetone in human breath by gas chromatography–mass spectrometry and solid-phase microextraction with on-fiber derivatization

A selective nanosensing probe for nitric oxide

Mass Spectrometric Profiling of Low-Molecular-Weight Volatile Compounds - Diagnostic Potential and Latest Applications

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